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Mitogen-Activated Protein Kinase Phosphatases

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Definition: A subcategory of phosphohydrolases that are specific for MITOGEN-ACTIVATED PROTEIN KINASES. They play a role in the inactivation of the MAP KINASE SIGNALING SYSTEM.     
Examples Dual Specificity Phosphatase 1; Dual Specificity Phosphatase 2; Dual Specificity Phosphatase 3; Dual Specificity Phosphatase 6 		Other names Phosphatases, MAPK; Mitogen Activated Protein Kinase Phosphatases; MAPK Phosphatases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
PP2C5 protein, Arabidopsis  EC 3.1.3.-   *Arabidopsis Proteins *Mitogen-Activated Protein Kinase Phosphatases. Plant Physiol 2010 Jul;153(3):1098-111
DUSP26 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Biochem Biophys Res Commun 2005 May 6;330(2):511-8
DUSP14 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases.
DUSP4 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases.
DUSP22 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13613-8
DUSP16 protein, human  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 2001 Oct 19;276(42):39002-11
Dusp16 protein, mouse  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. Mol Cell Biol 2001 Oct;21(20):6999-7009
DUSP10 protein, human  EC 3.1.3.16   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1999 Jul 9;274(28):19949-56; Oncogene 1999 Nov 25;18(50):6981-8
DUSP9 protein, human  EC 3.1.3.-   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1997 Feb 21;272(8):5141-51
XCL100 protein, Xenopus  EC 3.1.3.-   *Xenopus Proteins *Mitogen-Activated Protein Kinase Phosphatases. J Cell Sci 1995 Aug;108(Pt 8):2885-96
Dusp4 protein, rat  EC 3.1.3.48   *Dual-Specificity Phosphatases *Mitogen-Activated Protein Kinase Phosphatases. J Biol Chem 1995 Jun 16;270(24):14587-96

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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