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Quinolizidines
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Definition
: Saturated quinolizines that are two fused six-membered rings with a nitrogen atom at the ring fusion. They are biosynthesized in PLANTS by cyclization of a LYSINE coupled to CADAVERINE. Many of them are naturally occurring ALKALOIDS.
Examples
Sparteine
Substance
CAS Registry & name
Categories
Source
Drugs
*
lagerine N-
oxide
0
*Biphenyl Compounds
*Cyclic N-Oxides
*Quinolizidines.
Planta Med. 2011 Dec;77(18):2037-41
lagerstroemine N-
oxide
0
*Biphenyl Compounds
*Cyclic N-Oxides
*Quinolizidines.
Planta Med. 2011 Dec;77(18):2037-41
5-
epi-
dihydrolyfoline N-
oxide
0
*Biphenyl Compounds
*Cyclic N-Oxides
*Quinolizidines.
Planta Med. 2011 Dec;77(18):2037-41
decamine N-
oxide
0
*Biphenyl Compounds
*Cyclic N-Oxides
*Quinolizidines
Alkaloids.
Planta Med. 2011 Dec;77(18):2037-41
petrosin
0
*Quinolizidines
Alkaloids.
Org Lett. 2010 Nov 19;12(22):5196-9
N-
(1-
(1-
(2-
carbamoylpyrrolidin-
1-
yl)-
3-
(4-
fluorophenyl)-
1-
oxopropan-
2-
ylamino)-
4-
cyclohexyl-
1-
oxobutan-
2-
yl)-
1,2,3,4,6,7,12,12b-
octahydroindolo(2,3-
a)quinolizine-
3-
carboxamide
0
*Oligopeptides
*Quinolizidines
Ligands.
J Pharmacol Exp Ther 2010 Mar;332(3):876-85
schulzeine A
0
*Sulfuric Acid Esters
*Quinolizidines
alpha-Glucosidases/antagonists & inhibitors.
J Am Chem Soc 2009 May 6;131(17):6062-3
dihydrolyfoline
0
*Alkaloids
*Quinolizidines
Stereoisomerism.
J Nat Prod 2009 Apr;72(4):749-52
lehmannine
0
*Alkaloids
*Quinolizidines
Drugs, Chinese Herbal.
Biomed Chromatogr 2008 Oct;22(10):1149-54
cermizine D
0
*Quinolizidines.
Org Lett 2008 May 15;10(10):1987-90
9-
deoxy-
9a-
homocastanospermine
0
*Quinolizidines.
Org Biomol Chem 2008 Feb 21;6(4):703-11
9a-
homocastanospermine
0
*Quinolizidines.
Org Biomol Chem 2008 Feb 21;6(4):703-11
1-
hydroxyquinolizidinone
0
*Quinolizidines.
Org Lett. 2007 Nov 8;9(23):4705-8
lutenurine
12698-70-3
*Quinolizidines.
Vestn Dermatol Venerol (1):48;1979