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Topoisomerase II Inhibitors

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Definition: Compounds that inhibit the activity of DNA TOPOISOMERASE II.      Other names Inhibitors, Topoisomerase II; Inhibitors, Topoisomerase 2; DNA Type 2 Topoisomerase Inhibitors; DNA Topoisomerase II Inhibitors; Topoisomerase 2 Inhibitors
Substances having this pharmacologic action: asulacrine; 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one; pixantrone; 4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione; sobuzoxane; N-(2'-(dimethylamino)ethyl)acridine-4-carboxamide; merbarone
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-((4'-benzylpiperdin-4-yl)amino)-4'-O-demethylepipodophyllotoxin  0   *Piperidines Podophyllotoxin/*analogs & derivatives Topoisomerase II Inhibitors. Cancer Sci. 2012 Jan;103(1):80-7.
tricitinol B  0   *Benzopyrans *Heterocyclic Compounds with 4 or More Rings Topoisomerase II Inhibitors. J Med Chem. 2011 Aug 25;54(16):5796-810.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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