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geldanamycin
under Benzoquinones
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Benzoquinones
Definition
: Benzene rings which contain two ketone moieties in any position. They can be substituted in any position except at the ketone groups.
Other names
p-
Benzoquinones; o-
Benzoquinones; 2,5-
Cyclohexadiene-
1,4-
Diones; Benzodiones; 1,4-
Benzoquinones; 1,2-
Benzoquinones
Substance
CAS Registry & name
Categories
Source
Drugs
*
geldanamycin [ geldanomycin ]
unlike the related ansamycins, geldanamycin possesses a methoxyl at C17 on the quinone; from culture filtrates of Streptomyces hygroscopicus var. geldanus var. Nova.
30562-34-6
*Benzoquinones
*Lactams
, Macrocyclic
Protein-Tyrosine Kinases/antagonists & inhibitors
HSP90 Heat-Shock Proteins
Pharma Action
Antibiotics, Antineoplastic
;
Antiviral Agents
;
Enzyme Inhibitors
;
Cysteine Proteinase Inhibitors
Cancer Treat Rep 61(5):815;1977; J Am Chem Soc 99(10):3541;1977; J Antibiot (Tokyo) 23(9):442;1970; J Antibiot(Tokyo) 1979;32(8):849; Mol Pharmacol 14:422;1978; Proc Soc Exp Biol Med 155:461;1977