Aequorin (definition)

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Aequorin

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Definition: A photoprotein isolated from the bioluminescent jellyfish Aequorea. It emits visible light by an intramolecular reaction when a trace amount of calcium ion is added. The light-emitting moiety in the bioluminescence reaction is believed to be 2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine (AF-350).

Pharmacological Action Luminescent Agents

Other names Aequorine

Substance	CAS Registry & name	Categories	Source
dehydrocoelenterazine	0	Imidazoles Pyrazines Aequorin Luminescent Agents.	Bioorg Med Chem Lett 1998 Oct 20;8(20):2919-24
apoaequorin	0	Aequorin Apoproteins Recombinant Proteins Calcium-Binding Proteins.	J Biochem (Tokyo) 1989;105(3):473
coelenterazine	55779-48-1 Imidazo(1,2-a)pyrazin-3(7H)-one, 6-(4-hydroxyphenyl)-2-((4-hydroxyphenyl)methyl)-8-(phenylmethyl)	Imidazoles Pyrazines Aequorin. Pharma Action Luminescent Agents	Proc Nat Acad Sci USA 75(6):2611;1978
2-amino-3-benzyl-5-(p-hydroxyphenyl)pyrazine	37156-84-6 Phenol, 4-(5-amino-6-(phenylmethyl)pyrazinyl)	*Pyrazines Aequorin Luminescent Agents.	Biochemistry 11(9):1602;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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