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Butyrophenones

More information in Books or onNLM PubMed
Definition: Compounds containing phenyl-1-butanone.     
See Also Antipsychotic Agents
Examples Azaperone; Benperidol; Droperidol; Haloperidol; Spiperone; Trifluperidol
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-fluoro-4-(1,2,3,6-tetrahydro-1,3-dimethyl-2-oxo-6-thionpurin-8-ylthio)butyrophenone  0   *Butyrophenones *Purines Estrogen Receptor alpha/antagonists & inhibitors. J Biol Chem 2010 Dec 31;285(53):41863-73
4-(4-(4-chlorophenyl)-1,4-diazepan-1-yl)-1-(4-fluuorophenyl)butan-1-one  0   *Azepines *Butyrophenones. Bioorg Med Chem 2008 Aug 1;16(15):7291-301
4'-hydroxymethyl-alpha-pyrrolidinobutyrophenone  0   *Butyrophenones *Pyrrolidines. Biochem Pharmacol 2007 Aug 1;74(3):511-20
desacetylsalannobutyrolactone  0   *Butyrophenones *Heterocyclic Compounds with 4 or More Rings. Fitoterapia. 2005 Dec;76(7-8):740-3
salannobutyrolactone  0   *Butyrophenones *Heterocyclic Compounds with 4 or More Rings. Fitoterapia. 2005 Dec;76(7-8):740-3
4'-methyl-alpha-pyrrolidinobutyrophenone  0   *Butyrophenones *Pyrrolidines. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Sep 25;824(1-2):81-91
hydroxyebastine  0   *Butyrophenones *Piperidines. J Chromatogr B Biomed Sci Appl 2001 Jun 5;757(1):173-9
4-fluoro-4(p-nitrophenyl)-2-butanone  0   *Butyrophenones. Biomol Eng 2001 Aug;18(1):1-7
4,4-bis(4-chlorophenyl)-4-hydroxypiperidinobutyrophenone  0   *Butyrophenones *Piperidines. Acta Pol Pharm 2000 Jan-Feb;57(1):23-6
4-(4-(4-diphenylmethoxy-1-piperidyl)butyryl)dimethylphenylacetic acid  0   *Butyrophenones *Piperidines. Int J Clin Pharmacol Ther 1996 Dec;34(12):546-9
lenperone  24678-13-5   *Butyrophenones.
1-(4-fluorophenyl)-4-(4-(5-fluoro-2-pyrimidinyl)-1-piperazinyl)butan-1-one  133982-66-8   *Butyrophenones *Pyrimidines. Biotechnol Appl Biochem 1993 Apr;17(Pt 2):139-53
acetabutone  807-31-8   *Butyrophenones.
filicin  4482-83-1   *Butyrophenones Plant Extracts. Pharmacol Res Commun 1988; 20 Suppl 5:135
mobenzoxamine  65329-79-5   *Butyrophenones *Piperazines. Nippon Yakurigaku Zasshi 1988;92(5):297
carebastine  90729-42-3 Benzeneacetic acid, 4-(4-(4-(diphenylmethoxy)-1-piperidinyl)-1-oxobutyl)-alpha,alpha-dimethyl  *Butyrophenones *Piperidines.
Pharma Action Histamine H1 Antagonists ; Anti-Asthmatic Agents 		Br J Clin Pharmacol 1988;26(5):497
ebastine  90729-43-4   *Butyrophenones *Piperidines.
Pharma Action Histamine H1 Antagonists 		Br J Clin Pharmacol 1988;26(5):497
dihydrolenperone  38077-12-2   *Butyrophenones. Cancer Treat Rep 1986;70(1):9
N-(2-(2-butanoyl)-4-nitrophenoxyethyl)-N,N-bis(2-chloroethyl)amine  92756-01-9 1-Butanone, 1-(2-(2-(bis(2-chloroethyl)amino)ethoxy)-5-nitrophenyl)-, (S-(E))  *Butyrophenones *Nitrogen Mustard Compounds. J Pharm Sci 1984;73(8):1175
N,N-bis(2-(2-butanoyl)-4-nitrophenoxyethyl)-N-(2-chloroethyl)amine  92756-02-0 1-Butanone, 1,1'-(((2-chloroethyl)imino)bis(2,1-ethanediyloxy(5-nitro-2,1-phenylene)))bis-, (S-(E))  *Butyrophenones *Nitrogen Mustard Compounds. J Pharm Sci 1984;73(8):1175
CIBA 3315A-Go  0   *Butyrophenones. J Assoc Physicians India 1982;30(7):433
timiperone  57648-21-2 4-(4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl)-1-(4-fluorophenyl)-1- butanone  *Butyrophenones.
Pharma Action Antiemetics ; Antipsychotic Agents 		Eur J Pharmacol 59(3-4):245;1979
itanoxone  58182-63-1 2'-chloro-alpha-methylene-gamma-oxo-(1,1'-biphenyl)-4-butanoic acid  *Butyrophenones. J Pharm Sci 69(1):49;1980
67332MD  26964-71-6 1-(4'-fluorophenyl)-4-(cyclohexyl-1'-piperazinyl- 4'-carboxylate)-butane-1-one.HCl  *Butyrophenones. Xenobiotica 7(5):315;1977
cloroperone  61764-61-2 1-butanone, 4-(4-(4-chlorobenzoyl)-1-piperdinyl)-1-(4-fluorophenyl)  *Butyrophenones. Drug Metab Dispos 4(6):562;1976; Prog Neuropsychopharmacol 2(1):117;1978
azabutyrone  2856-81-7   *Butyrophenones. Anesteziol Reanimatol 5:35;1977; Farmakol Toksikol 39(1):59;1976; Farmakol Toksikol 39(4):402;1976; Farmakol Toksikol 39(5):517;1977; Farmakol Toksikol 41(2):154;1978; Farmakol Toksikol 41(3):289;1978; Farmatsiia 25(1):77;1976; Vestn Otorinolaringol 4:55;1977
U 35,777A  55199-71-8 4'-fluoro-4-((4-(p-fluorophenyl)-4- methoxycyclohexyl)amino)butyrophenone.HCl  *Butyrophenones. J Pharmacol 193(1):88;1975
ketocaine  1092-46-2 1-butanone, 1-(2-(2-(bis(1-1-methylethyl)amino)ethoxy)phenyl)  *Butyrophenones. Acta Anesthesiol Scand 18(4):306;1974; Acta Pharm Suec 14(5-6):425;1977; Br J Anaesth 1979;51(12):1189; Br J Plast Surg 30:251;1977; Scand J Plast Reconstr Surg (Suppl) 11(1):79;1977; Scand J Plast Reconstructr Surg 11(1):79;1977
metylperon  3575-80-2 4'-fluor-4-(4-methylpiperidino)-butyrophenone  *Butyrophenones Anti-Arrhythmia Agents.
Pharma Action Antipsychotic Agents 		Acta Pharmacol Toxicol (Copenh) 42(5):388;1978; Acta Pharmacol Toxicol (Copenh) 43(2):129;1978; Acta Pharmacol Toxicol 38:145;1976; Arch Psychiatr Nervenkr 224:281;1977; Arzneim Forsch 1979;29(3):574; Eur J Pharmacol 49:285;1978; Farmaco (Prat) 29(10):586;1974; Int J Clin Pharmacol Biopharm 16(7):331;1978; Int J Clin Pharmacol Biopharm 1979;17(8):341; Naunyn Schmiedebergs Arch Pharmacol 304(1):27;1978; Pharmakopsychiatr Neuropsychopharmakol 11(2):86;1978; Pharmakopsychiatr Neuropsychopharmakol 1980;13(1):20; Psychopharmacologie 43(1):95;1975; Tidsk Nor Lageforen 95(23):1302;1975; Ugeskr Laeger 136(15):809;1974
centpyraquin  26049-76-3 3-(gamma-p-fluorobenzoylpropyl)2,3,4,4a,5,6- hexahydro-1(H)-pyrazino(1,2-a)quinoline.HCl  *Butyrophenones. Experientia 29(12):1529;1973
U-32,802A  36735-48-5 4'-fluoro-4-((4-(p-fluorophenyl)-3-cyclohexen-1-yl)- amino)-butyrophenone  *Butyrophenones. Biochem Pharmacol 23(12):1701;1974; Br J Pharmacol 1979;67(1):115
pipamperone  1893-33-0   *Butyrophenones.
Pharma Action Serotonin Antagonists ; Antipsychotic Agents 		Acta Psychiatr Belg 76(1):157;1976; Acta Psychiatr Belg 76(4):688;1976; Acta Psychiatr Belg 77:754;1977; Acta Psychiatr Belg 78(2):392;1978; Acta Psychiatr Scand 52(4):237;1975; Arch Int Pharmacodyn 217:280;1975
moperone  1050-79-9   *Butyrophenones.
fluanisone  1480-19-9 4'-fluoro-4-(4-(o-methoxyphenyl)-1-piperazinyl)- butyrophenone  *Butyrophenones.
Pharma Action Hypnotics and Sedatives ; Antipsychotic Agents 		Encephale 4(2):145;1978; Lab Animals 9(3):161;1975
flavaspidic acid  114-42-1 3'-((5-butyryl-2,4-dihydroxy-3,3-dimethyl-6-oxo-1,4-cyclohexadien-1-yl)methyl)-5'-methylphloro butyrophenone  *Butyrophenones. Biochem Pharmacol 27:897;1978; Biochim Biophys Acta 1980;617(1):156
desaspidin  114-43-2 3'-((5-butyryl-2,4-dihydroxy-3,3-dimethyl-6-oxo-1,4-cyclohexadien-1-yl)methyl)-2',6'-dihydroxy-4'-methoxybutyrophenone  *Butyrophenones. Med Parazitol (Mosk) 45(5):611;1976
carperone  20977-50-8 (1-methylethyl)carbamic acid, 1-(4-(4-fluorophenyl)-4-oxobutyl)-4-piperidinyl ester  *Butyrophenones *Carbamates.
NSD 2023  3935-01-1   *Butyrophenones. Br J Pharmacol 45(3):490;1972
Hypnorm  52869-98-4 N-phenyl-N-(1-(2-phenylethyl)-4-piperidinylpropanamide mixt. with 1-(4-fluorophenyl)-4-(4-(2- methoxyphenyl)-1-piperazinyl)-1-butanone  *Butyrophenones *Fentanyl Drug Combinations. Br J Cancer 38(6):725;1978
flavaspidic acid-N-methylglucaminate  992-18-7   *Butyrophenones. Br J Pharm 27(20):2425;1978; Life Sci 24(7):587;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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