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Dihydroorotase

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Definition: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.      Other names Dihydro-Orotate Amidohydrolase; Dihydro-Orotase; Carbamoylaspartic Dehydrase; Dihydro Orotate Amidohydrolase; Dihydro Orotase; Dehydrase, Carbamoylaspartic; Amidohydrolase, Dihydro-Orotate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-aminoorotic acid  0   Orotic Acid/*analogs & derivatives Dihydroorotase/antagonists & inhibitors. Drug Metab Dispos 2008 Sep;36(9):1780-5
4-mercapto-6-oxo-1,4-azaphosphinane-2-carboxylic acid 4-oxide  0   *Cyclic N-Oxides Dihydroorotase/antagonists & inhibitors. J Med Chem 1998 Nov 5;41(23):4550-5
PYR3 protein, Ustilago maydis  148412-40-2   *Dihydroorotase *Fungal Proteins. Gene 1992 Aug 1;117(1):73-9
2-oxo-1,2,3,6-tetrahydropyrimidine-4,6-dicarboxylate  114832-72-3   Orotic Acid/*analogs & derivatives Dihydroorotase/antagonists & inhibitors. Cancer Res 1990;50(24):7793
6-thiodihydroorotate  118438-67-8   Orotic Acid/*analogs & derivatives Dihydroorotase/antagonists & inhibitors. Cancer Res 1990;50(24):7793
4-carboxy-6-(mercaptomethyl)-3,4,5,6-tetrahydropyrimidin-2(1H)-one  114132-84-2   *Pyrimidinones Dihydroorotase/antagonists & inhibitors. J Med Chem 1988;31(7):1355
CAD trifunctional enzyme  0   *Aspartate Carbamoyltransferase *Dihydroorotase *Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) Neoplasm Proteins. Cell 1981;27(2)267

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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