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Dihydroorotase
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Definition
: An enzyme that, in the course of pyrimidine biosynthesis, catalyzes ring closure by removal of water from N-carbamoylaspartate to yield dihydro-orotic acid. EC 3.5.2.3.
Other names
Dihydro-
Orotate Amidohydrolase; Dihydro-
Orotase; Carbamoylaspartic Dehydrase; Dihydro Orotate Amidohydrolase; Dihydro Orotase; Dehydrase, Carbamoylaspartic; Amidohydrolase, Dihydro-
Orotate
Substance
CAS Registry & name
Categories
Source
Drugs
*
5-
aminoorotic acid
0
Orotic Acid/*analogs & derivatives
Dihydroorotase/antagonists & inhibitors.
Drug Metab Dispos 2008 Sep;36(9):1780-5
4-
mercapto-
6-
oxo-
1,4-
azaphosphinane-
2-
carboxylic acid 4-
oxide
0
*Cyclic N-Oxides
Dihydroorotase/antagonists & inhibitors.
J Med Chem 1998 Nov 5;41(23):4550-5
PYR3 protein, Ustilago maydis
148412-40-2
*Dihydroorotase
*Fungal Proteins.
Gene 1992 Aug 1;117(1):73-9
2-
oxo-
1,2,3,6-
tetrahydropyrimidine-
4,6-
dicarboxylate
114832-72-3
Orotic Acid/*analogs & derivatives
Dihydroorotase/antagonists & inhibitors.
Cancer Res 1990;50(24):7793
6-
thiodihydroorotate
118438-67-8
Orotic Acid/*analogs & derivatives
Dihydroorotase/antagonists & inhibitors.
Cancer Res 1990;50(24):7793
4-
carboxy-
6-
(mercaptomethyl)-
3,4,5,6-
tetrahydropyrimidin-
2(1H)-
one
114132-84-2
*Pyrimidinones
Dihydroorotase/antagonists & inhibitors.
J Med Chem 1988;31(7):1355
CAD trifunctional enzyme
0
*Aspartate Carbamoyltransferase
*Dihydroorotase
*Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)
Neoplasm Proteins.
Cell 1981;27(2)267