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Myelin Basic Proteins

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Definition: A group of 7 proteins produced from a single gene by alternate splicing found in central and peripheral nervous system myelin. The major basic protein (MBP) has long been of interest because it is the antigen, that, when injected into an animal, elicits a cellular immune response that produces the CNS autoimmune disease called experimental allergic encephalomyelitis (ENCEPHALOMYELITIS, ALLERGIC). In the peripheral nervous system, myelin basic protein 18.5-kDa is often referred to as the P1 protein. (From Siegel et al., Basic Neurochemistry, 5th ed, p130, 133)  /biosyn /drug eff /physiol /ultrastruct permitted; note X ref: do not index under ENCEPHALOMYELITIS, ALLERGIC unless the disease is discussed; DF: ENCEPH BASIC PROTEINS   
Examples Myelin P2 Protein
Other names Encephalitogenic Basic Proteins; Proteins, Myelin Basic; Protein, Neuritogenic; Basic Proteins, Myelin; Proteins, Encephalitogenic Basic; Protein, Encephalitogenic Basic; Neuritogenic Protein; Encephalitogenic Basic Protein; Basic Proteins, Encephalitogenic; Basic Protein, Encephalitogenic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MBP-8298  0   *Myelin Basic Proteins *Peptide Fragments. Curr Opin Mol Ther 2007 Aug;9(4):398-402
myelin basic protein (87-99), Ala(91,96)  0   *Myelin Basic Proteins *Peptide Fragments. J Med Chem 2006 Nov 16;49(23):6683-91
myelin basic protein (87-99), Arg(91)-Ala(96)  0   *Myelin Basic Proteins *Peptide Fragments. Bioorg Med Chem 2000 Aug;8(8):1903-9
(Lys-Gly)(5)cyclo(75-82)MBP(74-85)  0   *Myelin Basic Proteins *Peptide Fragments. Anal Biochem. 2005 Dec 1;347(1):121-8
myelin basic protein 63-88  0   *Myelin Basic Proteins *Peptide Fragments. J Neuroimmunol 2005 Sep;166(1-2):47-54
cyclo(87-99)myelin basic protein (87-99)  0   *Myelin Basic Proteins *Peptides, Cyclic. J Med Chem 2005 Mar 10;48(5):1470-80
MBP protein, human  0   *Myelin Basic Proteins.
Mbp protein, mouse  0   *Myelin Basic Proteins.
myelin basic protein 152-165  0   *Myelin Basic Proteins *Peptide Fragments. J Med Chem 2004 Oct 7;47(21):4989-97
golli-interacting protein, mouse  0   *Nerve Tissue Proteins *Nuclear Proteins Myelin Basic Proteins. J Neurosci Res. 2004 Feb 15;75(4):461-71
myelin basic protein 1-20  0   *Myelin Basic Proteins *Peptide Fragments. Cell Immunol 2002 May-Jun;217(1-2):87-94
myelin basic protein 89-101  0   *Myelin Basic Proteins *Peptide Fragments. Nat Immunol 2002 Feb;3(2):175-81
immunoglobulin-MBP3 protein, chimeric  0   *Myelin Basic Proteins *Immunoglobulins *Recombinant Fusion Proteins. J Immunol 2001 Oct 15;167(8):4187-95
Mbp protein, rat  0   *Myelin Basic Proteins. J Neuroimmunol. 2001 Sep 3;119(1):64-72
myelin basic protein 81-100  0   *Myelin Basic Proteins *Peptide Fragments. Mol Immunol 2000 Nov;37(16):951-60
myelin basic protein 121-150  0   *Myelin Basic Proteins *Peptide Fragments. Immunity 2001 Apr;14(4):471-81
myelin basic protein 86-98(98A)  0   *Myelin Basic Proteins *Peptide Fragments. Int Immunol 2000 Aug;12(8):1135-43
NBI 5788  0   *Myelin Basic Proteins *Peptide Fragments. Genomics 2000 Sep 15;68(3):1176-82
CGP 77116  0   *Myelin Basic Proteins *Peptide Fragments. Nat Med 2000 Oct;6(10):1167-75
myelin basic protein 84-102  0   *Myelin Basic Proteins *Peptide Fragments Immunotherapy Multiple Sclerosis. Neurology 2000 Apr 11;54(7):1414-20
myelin basic protein Ac1-11(4Y)  0   *Myelin Basic Proteins *Peptide Fragments. J Neurosci Res 1999 Feb 15;55(4):432-40
myelin basic protein 1-11  0   *Myelin Basic Proteins *Peptide Fragments. J Neurosci Res 1999 Feb 15;55(4):432-40
MBP-PE40  0   *Myelin Basic Proteins *Exotoxins *Recombinant Fusion Proteins *ADP Ribose Transferases Immunotoxins. Immunol Lett 1999 Jun 1;68(2-3):403-10
myelin basic protein 72-85  0   *Myelin Basic Proteins *Peptide Fragments. J Med Chem 1999 Apr 8;42(7):1170-7
myelin basic protein 73-86  0   *Myelin Basic Proteins *Peptide Fragments. J Immunol 1999 Jan 15;162(2):829-36
myelin basic protein 87-99  0   *Myelin Basic Proteins *Peptide Fragments. Int Immunol 1998 Aug;10(8):1139-48
myelin basic protein 70-88  0   *Myelin Basic Proteins *Peptide Fragments. J Neuroimmunol 1998 Aug 1;88(1-2):21-9
myelin basic protein 83-102  0   *Myelin Basic Proteins *Peptide Fragments. J Immunol Methods 1998 Mar1;212(1):49-59
myelin basic protein 79-87  0   *Myelin Basic Proteins *Peptide Fragments. J Exp Med 1998 Jun 15;187(12):2055-63
myelin basic protein 68-86  0   *Myelin Basic Proteins *Peptide Fragments. Neuroreport 1997 Dec 1;8(17):3727-30
myelin basic protein 85-99  0   *Myelin Basic Proteins *Peptide Fragments. J Immunol 1997 Sep 1;159(5):2502-12
myelin basic protein 83-99  0   *Myelin Basic Proteins *Peptide Fragments T-Lymphocytes Immunodominant Epitopes. J Neurosci Res 1996 Sep 15;45(6):852-62
MP4 protein, chimeric  0   *Myelin Basic Proteins *Recombinant Fusion Proteins *Myelin Proteolipid Protein. J Clin Invest 12996 Oct 1;98(7):1602-12
myelin basic protein 84-104  0   *Myelin Basic Proteins *Peptide Fragments. J Exp Med 1995 Jul 1;182(1):75-85
myelin basic protein 68-88  0   *Myelin Basic Proteins *Peptide Fragments Epitopes. Eur J Immunol 1993 Feb;23(2):494-8
myelin peptide amide-16  141311-87-7   *Myelin Basic Proteins *Peptide Fragments. Neurochem Res 1992 Mar;17(3):239-46
myelin peptide amide-12  141311-86-6   *Myelin Basic Proteins. Neurochem Res 1992 Mar;17(3):239-46
myelin basic protein 1-9  0   *Myelin Basic Proteins *Peptide Fragments. Clin Immunol Immunopathol 1992 Apr;63(1):74-83
myelin basic protein 1-14  0   *Myelin Basic Proteins *Peptide Fragments. Biochem Biophys Res Commun 1990;172(3):1167
dansyl myelin basic protein, Gly(119)-Gly(131)-, synthetic  129189-42-0   *Dansyl Compounds *Myelin Basic Proteins *Recombinant Proteins. Biochem Int 1990;21(1):1
myelin basic protein 80-89  0   *Myelin Basic Proteins *Peptide Fragments. J Neurochem 1990;55(2):568
myelin basic protein 59-74  0   *Myelin Basic Proteins *Peptide Fragments. Neurochem Res 1987;12(1):9
myelin basic protein 114-122  0   *Myelin Basic Proteins *Peptide Fragments. Biull Eksp Biol Med 1987;103(1):92
myelin basic protein octapeptide  0   *Myelin Basic Proteins *Peptide Fragments. Biochem J 1985;229(2):305
myelin basic protein 45-89  0   *Myelin Basic Proteins *Peptide Fragments. J Biol Chem 1984;259(8):5028
myelin basic protein 43-88  0   *Myelin Basic Proteins *Peptide Fragments. J Chromatogr 1983;254:211
myelin basic protein Pr  0   *Myelin Basic Proteins. J Neurochem 1981;36(4):1506
myelin basic protein P1  0   *Myelin Basic Proteins. J Neurochem 1981;36(4):1506
peptide L  0   *Myelin Basic Proteins *Peptide Fragments. Biochemistry 17(21):4571;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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