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Gramicidin

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Definition: A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN which is used topically for gram-positive organisms. It is toxic to blood, liver, kidneys, meninges, and the olfactory apparatus.     
Pharmacological Action Anti-Bacterial Agents; Anti-Infective Agents, Local 		Other names Gramicidin, Linear; Linear Gramicidin; Gramoderm; Gramicidins; Gramicidin S; Gramicidin P; Gramicidin NF; Gramicidin K; Gramicidin J; Gramicidin Dubos; Gramicidin D; Gramicidin C; Gramicidin B; Gramicidin A(1); Gramicidin ADrugs* : NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN; NEOMYCIN SULFATE AND POLYMYXIN B SULFATE GRAMICIDIN; NEO-POLYCIN
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
cyclo(lysyl(1,1')-ornithyl(2,2')-lysyl(3,3')-phenylalanyl(4,4')-prolyl(5,5'))  0   Gramicidin/*analogs & derivatives. J Antibiot (Tokyo) 2009 Oct;62(10):597-9
cyclo(ornithyl(1,1')-ornithyl(2,2')-ornithyl(3,3')-phenylalanyl(4,4')-prolyl(5,5'))  0   Gramicidin/*analogs & derivatives. J Antibiot (Tokyo) 2009 Oct;62(10):597-9
(D-Leu(10))-gramicidin A  0   Gramicidin/*analogs & derivatives. Biophys J. 2006 Oct 15;91(8):3076-84
O-pyromellitylgramicidin  0   Gramicidin/*analogs & derivatives. J Membr Biol 2002 Sep 15;189(2):119-30
polysporin ointment  0   *Bacitracin *Gramicidin *Polymyxin B Drug Combinations Ointments. Infect Control Hosp Epidemiol 2000 Oct;21(10):653-5
N'-biotinyl-(ethylenediamine)15-gramidicin A  0   Biotin/*analogs & derivatives Gramicidin/*analogs & derivatives. J Pept Sci 1998 Sep;4(6):371-7
gramicidin B Aib  0   Gramicidin/*analogs & derivatives. J Biochem (Tokyo) 1998 May;123(5):790-7
dicortineff  0   *Gramicidin *Neomycin *Penicillin G Drug Combinations Fludrocortisone/*analogs & derivatives. Otolaryngol Pol 1992;46(1):57-61
tryptophan-N-formylgramicidin  0   Gramicidin/*analogs & derivatives. Biochim Biophys Acta 1991;1062(2):206
gradex  129711-39-3 Gradex  *Dextrans Gramicidin/*analogs & derivatives. Antibiot Khimioter 1990;35(8):20
des(formylvalyl)gramicidin  0   Gramicidin/*analogs & derivatives. Biochemistry 1989;28(10):4361
desformylgramicidin  63808-16-2 Gramicidin A, N-deformyl-1-L-valine  Gramicidin/*analogs & derivatives. Biochemistry 1989;28(10):4361
des(ethanolamine)taurine(16)-gramicidin A  122613-26-7   Gramicidin/*analogs & derivatives Taurine/*analogs & derivatives. Biochim Biophys Acta 1989;982(2):223
9,11,13,15-(O-benzyl)tyrosylgramicidin A  112276-84-3   Gramicidin/*analogs & derivatives. Int J Pept Protein Res 1987;30(2):163
9,11,13,15-tyrosylgramicidin A  0   Gramicidin/*analogs & derivatives. Int J Pept Protein Res 1987;30(2):163
(4,4'-dehydrophenylalanine)gramicidin S  112209-92-4   Gramicidin/*analogs & derivatives. FEBS Lett 1987;222(2):251
gramicidin A, 7-alanine  99571-73-0   Gramicidin/*analogs & derivatives. Biochemistry 1986;25(2):456
gramicidin A, Leu(5)  92231-35-1 Gramicidin A, 1-L-valine-5-L-leucine-, (R)  Gramicidin/*analogs & derivatives. Biophys J 1984;46(2):259
gramicidin A, 7,8-des-Val  0   Gramicidin/*analogs & derivatives. Biochem Biophys Res Commun 1984;118(3):885
(4,4'-diaminopropionic acid)gramicidin S  87647-91-4 Gramicidin S, 2-(3-amino-D-alanine)-7-(3-amino-D-alanine)  Gramicidin/*analogs & derivatives. FEBS Lett 1983;161(1):89
gramicidin A, 15-des-Trp-Phe  65284-03-9 Gramicidin A, 1-L-valine-9-L-phenylalanine-11-L-phenylalanine-13-L-phenylalanine-15-(N-(2-hydroxyethyl)-L-phenylalaninamide)  Gramicidin/*analogs & derivatives. Biophys J 1982;40(1):87
monoformyl gramicidin S  82512-60-5 Gramicidin S, 5-(N5-formyl-L-ornithine)  Gramicidin/*analogs & derivatives. J Antibiot 1982;35(5):571
N,N'-diformyl gramicidin S  52212-77-8   Gramicidin/*analogs & derivatives. J Antibiot 1982;35(5):571
gramicidin A, Leu(2)  80713-06-0 Gramicidin A, 1-L-valine-2-D-leucine  Gramicidin/*analogs & derivatives. Biochim Biophys Acta 1981;649(2):281
N-acetylgramicidin  69514-72-3 Gramicidin A, 1-(N-acetyl-L-valine)  Gramicidin/*analogs & derivatives. Biochem Biophys Res Commun 1981;101(3):963
malonyl gramicidin  9066-61-9 Gramicidin A', 1,3-dioxo-1,3-propanediyl deriv.  Gramicidin/*analogs & derivatives. J Membr Biol 1980;55(1):29
(2,2'-L-serine)-gramicidin S  75993-96-3 Gramicidin S, 2-L-serine-7-L-serine  Gramicidin/*analogs & derivatives. J Antibiot (Tokyo) 1980;33(1):105
Sofradex  79173-16-3 Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16alpha)-, mixt. with O-2,6-diamino-2,6-dideoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-D-str  *Dexamethasone *Framycetin *Gramicidin Drug Combinations. Med J Aust 1980;1(2):84
phenylalanine racemase (ATP-hydrolyzing)  EC 5.1.1.11   *Amino Acid Isomerases Gramicidin. Biochim Biophys Acta 429(3):1062;1976; J Biochem (Tokyo) 84(2):435;1978
legrazol  78065-44-8 Gramicidin, mixt. with 2-butoxy-N-(2-(diethylamino)ethyl)-4-quinolinecarboxamide and (R-(R*,R*))-2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl)acetamide  *Balsams *Chloramphenicol *Dibucaine *Gramicidin Drug Combinations. Vrach Delo (3):92;1979
Tuplix  0   *Gramicidin *Neomycin Drug Combinations Triamcinolone/*analogs & derivatives. Actas Dermosifiliogr 67(11-12):757;1976
Gramicidin, Neomycin Sulfate, Nystatin, Triamcinolone Acetonide Drug Combination  0   *Gramicidin *Neomycin *Nystatin *Triamcinolone Acetonide Drug Combinations. Contact Dermatitis 1(6):344;1975; J Am Acad Dermatol 1979;1(2):131
imposit  77648-57-8 Gramicidin, mixt. with 2,4-dichlorobenzenemethanol, ethyl 4-aminobenzoate and 1-hexadecylpyridinium chloride  *Benzyl Alcohols *Cetylpyridinium *Gramicidin *4-Aminobenzoic Acid Drug Combinations. Allgemein Med 51(27):1211;1975; Ther Ggw 114(1):76;1975; Ther Ggw 115(11):1933;1976
gramesol  0   *Benzocaine *Gramicidin Drug Combinations. Vestn Otorinolaringol 35(1):33;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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