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Myosin-Light-Chain Kinase

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Definition: An enzyme that phosphorylates myosin light chains in the presence of ATP to yield myosin-light chain phosphate and ADP, and requires calcium and CALMODULIN. The 20-kDa light chain is phosphorylated more rapidly than any other acceptor, but light chains from other myosins and myosin itself can act as acceptors. The enzyme plays a central role in the regulation of smooth muscle contraction.  DF: MLCK    Other names Myosin Kinase; Myosin Regulatory Light Chain Kinase; Myosin Light Chain Kinase; LCK, Myosin; Kinase, Myosin-Light-Chain; Kinase, Myosin; Myosin Regulatory Light-Chain Kinase; Myosin LCK
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
non-muscle myosin light-chain kinase, mouse  EC 2.7.1.117   *Myosin-Light-Chain Kinase. Circulation. 2011 Jul 5;124(1):48-57
cardiac myosin light chain kinase, zebrafish  EC 2.7.1.117   *Myosin-Light-Chain Kinase *Zebrafish Proteins. J Clin Invest 2007 Oct;117(10):2812-24
cardiac myosin light chain kinase, human  EC 2.7.1.117   *Myosin-Light-Chain Kinase. J Clin Invest 2007 Oct;117(10):2812-24
11-(6-imino-3-phenylpyridazin-1(6H)-yl)-N-(2-(1-methylpyrrolidin-2-yl)ethyl)undecanamide  0   *Pyridazines *Pyrrolidines Myosin-Light-Chain Kinase/antagonists & inhibitors. Biochim Biophys Acta 2006 Nov;1763(11):1226-74
stretchin-klp protein, Drosophila  0   *Immunoglobulins *Drosophila Proteins Myosin-Light-Chain Kinase. J Muscle Res Cell Motil. 2005;26(4-5):213-24
MYPT1 protein, mouse  EC 3.1.3.53   *Myosin-Light-Chain Kinase. Circ Res 2006 May 12;98(9):1159-67
Dreverse PIK  0   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. Pharm Res 2005 May;22(5):703-9
MYLK protein, human  EC 2.7.11.18   *Calcium-Binding Proteins *Myosin-Light-Chain Kinase Kinesin.
Speg protein, mouse  EC 2.7.1.15   *Muscle Proteins *Myosin-Light-Chain Kinase.
non-muscle myosin light chain kinase, rabbit  EC 2.7.1.117   *Myosin-Light-Chain Kinase. World J Gastroenterol 2003 Dec;9(12):2715-9
obscurin-MLCK  EC 2.7.1.117   *Myosin-Light-Chain Kinase. Gene 2002 Jan 9;282(1-2):237-46
KT 7692  0   *Androstadienes Myosin-Light-Chain Kinase/antagonists & inhibitors Phosphatidylinositol 3-Kinases. Life Sci 2000 Oct 13;67(21):2587-93
Strn-Mlck protein, Drosophila  EC 2.7.1.117   *Myosin-Light-Chain Kinase *Drosophila Proteins. J Mol Biol 2000 Jul 21;300(4):759-77
Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2  0   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. J Med Chem 1999 Mar 11;42(5):910-9
MLCK-A protein, Dictyostelium discoideum  EC 2.7.1.-   *Myosin-Light-Chain Kinase *Protozoan Proteins. Proc Natl Acad Sci U S A 1998 Oct 27;95(22):13000-5
M13 protein (myosin light-chain kinase)  0   *Myosin-Light-Chain Kinase *Peptide Fragments. Anal Chem 1997 Aug 1;69(15):3081-5
myosin light chain kinase (774-807) amide  0   *Myosin-Light-Chain Kinase *Peptide Fragments. Biochem Biophys Res Commun 1996 Jul 25;324(3):690-5
MS 271  0   *Peptides, Cyclic Myosin-Light-Chain Kinase/antagonists & inhibitors. Bioorg Med Chem 1996 Jan;4(1):115-20
5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone  150045-18-4   *Furans *Naphthols Myosin-Light-Chain Kinase/antagonists & inhibitors. J Antibiot (Tokyo) 1995 Sep;48(9):948-51
AS19 peptide  0   *Calmodulin-Binding Proteins *Myosin-Light-Chain Kinase *Peptide Fragments. Arch Biochem Biophys 1995 Oct 1;322(2):429-36
dehydroaltenusin  0   *Benzopyrans Myosin-Light-Chain Kinase/antagonists & inhibitors. Biosci Biotech Biochem 1995 Jul;59(7):1333-5
atrovenetinone  0   *Naphthalenes Myosin-Light-Chain Kinase/antagonists & inhibitors. Biosci Biotech Biochem 1995 Jul;59(7):1333-5
altenusin  31186-12-6   *Biphenyl Compounds Myosin-Light-Chain Kinase/antagonists & inhibitors Sphingomyelin Phosphodiesterase/antagonists & inhibitors. Biosci Biotech Biochem 1995 Jul;59(7):1333-5
diperoxovanadate  0   *Peroxides *Vanadates Myosin-Light-Chain Kinase/antagonists & inhibitors. Arch Biochem Biophys 1995 Jan 10;316(1):319-26
SM 1  0   *Myosin-Light-Chain Kinase *Peptide Fragments. J Neurosci 1994 Dec;14(12):7695-703
MS 282b  0   *Furans Myosin-Light-Chain Kinase/antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Aug;47(8):855-61
MS 282a  0   *Furans Myosin-Light-Chain Kinase/antagonists & inhibitors Calcium-Calmodulin-Dependent Protein Kinases/antagonists & inhibitors. J Antibiot (Tokyo) 1994 Aug;47(8):855-61
MYLK protein, Bos taurus  0   *Myosin-Light-Chain Kinase. J Biochem (Tokyo) 1992 Dec;112(6):786-91
SQ 32732  149309-76-2   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Sep 30;187(3):1279-84
lysyl-arginyl-arginyl-phenylalanyl-lysyl-lysine  141363-42-0   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Sep 30;187(3):1279-84
lysyl-arginyl-arginyltryptophyl-lysyl-lysine  141363-41-9   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Sep 30;187(3):1279-84
SQ 31429  111394-11-7   *Oligopeptides Myosin-Light-Chain Kinase/antagonists & inhibitors. Biochem Biophys Res Commun 1992 Sep 30;187(3):1279-84
ML 7  109376-83-2 1H-1,4-Diazepine, hexahydro-1-((5-iodo-1-naphthalenyl)sulfonyl)  *Azepines *Naphthalenes Myosin-Light-Chain Kinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		FEBS Lett 1991;287(1-2):175
KT 5926  126643-38-7 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-16-propoxy-, methyl ester, (9alpha,10beta,12alpha)  *Carbazoles Myosin-Light-Chain Kinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Mol Pharmacol 1990;37(4):482
telokin  0   *Myosin-Light-Chain Kinase *Peptide Fragments. J Biol Chem 1989;264(24):13971
ML 9  105637-50-1   *Azepines Myosin-Light-Chain Kinase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Mol Pharmacol 1988;33(6):598

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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