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Phosphoric Diester Hydrolases

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Definition: A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.  /antag   
Examples Annexin A3; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterases; 2',3'-Cyclic-Nucleotide Phosphodiesterases; Glycerophosphoinositol Inositolphosphodiesterase; Phosphodiesterase I; Phospholipases; Sphingomyelin Phosphodiesterase 		Other names Phosphodiesterases; Hydrolases, Phosphoric Diester
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MPPED2 protein, human  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Mol Biol. 2011 Sep 23;412(3):481-94
PhnP protein, E.coli  EC 3.1.4.-   *Phosphoric Diester Hydrolases *Escherichia coli Proteins. J Am Chem Soc. 2011 Mar 16;133(10):3617-24
PDE11A protein, rat  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Brain Res. 2009 Jul 24;1281():25-34
Tdp1 protein, S pombe  0   *Phosphoric Diester Hydrolases *Schizosaccharomyces pombe Proteins DNA Repair Enzymes. EMBO J 2009 Mar;18;28(6):632-40
Tdp1 protein, mouse  EC 3.1.4.-   *Phosphoric Diester Hydrolases. EMBO J 2007 Nov 14;26(22):4720-31
Enpp3 protein, rat  EC 3.1.4.1   *Phosphoric Diester Hydrolases *Pyrophosphatases. J Cell Sci 2007 Mar 15;120(Pt 6):1009-16
PDE10A protein, rat  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Neuroscience 2006 May 12;139(2):597-607
YcgF protein, E coli  EC 3.1.4.-   *Phosphoric Diester Hydrolases *Escherichia coli Proteins. Biochemistry 2006 Mar 21;45(11):3785-93
Npp2 protein, S cerevisiae  EC 3.-   *Hydrolases *Saccharomyces cerevisiae Proteins Phosphoric Diester Hydrolases Pyrophosphatases. Eukaryot Cell 2005 Nov;4(11):1892-901
Npp1 protein, S cerevisiae  EC 3.-   *Hydrolases *Saccharomyces cerevisiae Proteins Phosphoric Diester Hydrolases Pyrophosphatases. Eukaryot Cell 2005 Nov;4(11):1892-901
Ypl206c protein, S cerevisiae  EC 3.1.4.2   *Phosphoric Diester Hydrolases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Nov 18;280(46):38290-6
Ypl110c protein, S cerevisiae  EC 3.1.4.2   *Phosphoric Diester Hydrolases *Saccharomyces cerevisiae Proteins. J Biol Chem 2005 Nov 18;280(46):38290-6
YajB protein, E coli  EC 3.1.4.14   *Phosphoric Diester Hydrolases *Escherichia coli Proteins. J Biol Chem 2005 Oct 14;280(41):34675-83
Tdp1 protein, S cerevisiae  EC 3.1.4.-   *Phosphoric Diester Hydrolases *Saccharomyces cerevisiae Proteins. Genetics 2005 Jun;170(2):591-600
ENPP6 protein, human  EC 3.1.4.46   *Phosphoric Diester Hydrolases. J Biol Chem 2005 Jun 17;280(24):23084-93
TDP1 protein, human  EC 3.1.4.-   *Phosphoric Diester Hydrolases.
Pde10a protein, mouse  EC 3.1.4.-   *Phosphoric Diester Hydrolases.
MTH2 protein, mouse  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Biochem Biophys Res Commun 2003 Jun 13;305(4):1073-7
ElaC protein, E coli  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Biol Chem 2002 Aug 9;277(32):29078-85
Dos protein, E coli  EC 3.1.4.-   *Phosphoric Diester Hydrolases *Escherichia coli Proteins. Biochemistry 2002 Jul 2;41(26):8414-21
diphosphonucleotide phosphatase-phosphodiesterase 2  EC 3.6.1.-   *Phosphoric Diester Hydrolases *Pyrophosphatases. FEBS Lett 2002 May 22;519(1-3):159-63
diphosphonucleotide phosphatase-phosphodiesterase 1  EC 3.6.1.-   *Phosphoric Diester Hydrolases *Pyrophosphatases. FEBS Lett 2002 May 22;519(1-3):159-63
N-acylphosphatidylethanolamine-hydrolyzing phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Biochim Biophys Acta 2001 May 31;1532(1-2):121-7
ENPP3 protein, human  0   *Phosphoric Diester Hydrolases *Pyrophosphatases. Blood 2001 May 15;97(10):3303-5
mesopram  0   *Oxazoles Phosphodiesterase Inhibitors Phosphoric Diester Hydrolases. J Neuroimmunol 2000 Aug 1;108(1-2):136-46
PDE11A protein, human  EC 3.1.4.35   *Phosphoric Diester Hydrolases. Proc Natl Acad Sci U S A 2000 Mar 28;97(7):3702-7
ushA protein, E coli  0   *Phosphoric Diester Hydrolases *Escherichia coli Proteins Escherichia coli Proteins. Biochem Biophys Res Commun 2000 Mar 16;269(2):526-31
nucleotide pyrophosphatase - phosphodiesterase I  EC 3.6.1.-   *Phosphoric Diester Hydrolases *Pyrophosphatases. Biochem J 2000 Feb 15;346( Pt 1):25-31
tyrosyl-DNA phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Science 1999 Oct 15;286(5439):552-5
PDE10A protein, human  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Proc Natl Acad Sci U S A 1999 Jun 8;96(12):7071-6
T 2585  0   *Phthalazines *Pyridines Phosphoric Diester Hydrolases/antagonists & inhibitors. J Med Chem 1999 Mar 25;42(6):1088-99
exonuclease IX, E coli  EC 3.1.-   *Exodeoxyribonucleases *Phosphoric Diester Hydrolases Escherichia coli Proteins. Nucleic Acids Res 1998 Jun 1;26(11):2593-7
G-rich protein, Carassius auratus  EC 3.1.4.-   *Nerve Tissue Proteins *Phosphoric Diester Hydrolases *Fish Proteins. Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8621-5
glpQ protein, Bacteria  EC 3.1.4.46   *Bacterial Proteins *Phosphoric Diester Hydrolases. Microbiology 1994 Apr;140(Pt 4):723-30
inositol cyclic 1,2-phosphate 1-phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Biol Chem 1992 Oct 5;267(28):19924-8
4-nitrophenylphosphorylcholine phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Neurosci Res 1992 Jan;31(1):68-74
F390 hydrolase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Biofactors 1991;3(1):61
oligophosphoglyceroyl-ATP 3'-phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Biochem J 1991;274(1):275
ectonucleotide pyrophosphatase phosphodiesterase 1  EC 3.1.4.1   *Phosphoric Diester Hydrolases *Pyrophosphatases. J Biol Chem 1990;265(29):17506
glycerophosphocholine cholinephosphodiesterase  EC 3.1.4.38   *Phosphoric Diester Hydrolases. FEBS Lett 1989;257(2):348
glucose-1-phospho-D-mannosylglycoprotein phosphodiesterase  EC 3.1.4.51   *Phosphoric Diester Hydrolases. J Biol Chem 1989;264(34):20540
UDP-galactose hydrolase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Aust J Biol Sci 1987;40(1):37
tRNA ligase, yeast  0   *Phosphoric Diester Hydrolases *Polynucleotide 5'-Hydroxyl-Kinase *Polynucleotide Ligases. Biochemistry 1988;27(24):8852
DNA deoxyribophosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Embo J 1988;7(11):3617
loxosceles venom  0   *Phosphoric Diester Hydrolases *Spider Venoms Serine Endopeptidases. J Peidatr 1988;112(3):496
sphingomyelin phosphodiesterase D  EC 3.1.4.41   *Phosphoric Diester Hydrolases. J Pediatr 1988;112(3):496
dolichyl-phosphate-mannose phosphodiesterase  EC 3.1.4.49   *Phosphoric Diester Hydrolases. Eur J Biochem 1987;170(1-2):363
N-acetylglucosaminyl pyrophosphorylpolyprenol hydrolase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. FEBS Lett 1987;218(1):131
alkylglycerophosphoethanolamine phosphodiesterase  EC 3.1.4.39   *Phosphoric Diester Hydrolases. Biochim Biophys Acta 1987;920(1):85
thiazole-4-carboxamide-adenine dinucleotide phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Biochem Pharmacol 1986;35(21):3783
glycerophosphodiester phosphodiesterase  EC 3.1.4.46   *Phosphoric Diester Hydrolases. J Biol Chem 1983;258(9):5428
teichoicase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. FEBS Lett 1982;149(1):67
monoacylglycerophosphorylglycerophosphorylglycerol phosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Lipids 1981;16(2):149
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase  EC 3.1.4.45   *Phosphoric Diester Hydrolases. J Biol Chem 1980;255(18):8398
RNA-tyrosine phosphatase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Biol Chem 1980;255(14):6739
serine-ethanolaminephosphate phosphodiesterase  EC 3.1.4.13   *Phosphoric Diester Hydrolases. Arch Biochem Biophys 1980;199(2):615
3'-nucleotidephosphodiesterase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. J Nat Cancer Inst 61(4):1077;1978
glycerophosphoinositol glycerophosphodiesterase  EC 3.1.4.44   *Phosphoric Diester Hydrolases. Biochem J 182(1):39;1979
adenosine diphosphoglucose glucohydrolase  EC 3.1.4.-   *Phosphoric Diester Hydrolases. Indian J Biochem Biophys 16(1):11;1979
glycerophosphocholine phosphodiesterase  EC 3.1.4.2   *Phosphoric Diester Hydrolases. Biochem J 1140(3):503;1974
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