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Superoxides

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Definition: Highly reactive compounds produced when oxygen is reduced by a single electron. In biological systems, they may be generated during the normal catalytic function of a number of enzymes and during the oxidation of hemoglobin to METHEMOGLOBIN. In living organisms, SUPEROXIDE DISMUTASE protects the cell from the deleterious effects of superoxides.     
Pharmacological Action Oxidants
See Also Reactive Oxygen Species; Respiratory Burst; Superoxide Dismutase 		Other names Superoxide Radical; Superoxide Anion; Superoxide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
superoxide reductase  EC 1.-   *Oxidoreductases Superoxides. Science 1999 Oct 8;286(5438):306-9
potassium superoxide  12030-88-5   *Superoxides. Mutat Res 1983;121(3-4):299
plumbagin  481-42-5   *Naphthoquinones Superoxides.
Pharma Action Adjuvants, Immunologic ; Anticoagulants ; Antinematodal Agents ; Antineoplastic Agents, Phytogenic ; Cardiotonic Agents ; Contraceptive Agents 		Gig Sanit 1979;10:67; Indian J Exp Biol 16(4):485;1978; Rev Inst Antibiot (Recife) 14(1-2):26;1974; Vopr Pitan 4:74;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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