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Tetracyclines

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Definition: Closely congeneric derivatives of the polycyclic naphthacenecarboxamide. (Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1117)  TETRACYCLINE is also available   
Examples Chlortetracycline; Demeclocycline; Doxycycline; Lymecycline; Methacycline; Minocycline; Oxytetracycline; Rolitetracycline; Tetracycline
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
7-fluoro-9-pyrrolidinoacetamido-6-demethyl-6-deoxytetracycline  0   *Tetracyclines. J Med Chem. 2012 Jan 26;55(2):597-605.
6-demethyl-6-deoxy-7-(dimethylamino)-8-azatetracycline  0   *Tetracyclines. J Med Chem 2011 Mar 10;54(5):1511-28
7-chloro-6-demethyl-6-deoxy-9-((3-(dimethylamino)-2,2-dimethylpropyl)amino)-8-azatetracycline  0   *Tetracyclines. J Med Chem 2011 Mar 10;54(5):1511-28
7-dimethylamino-9-(2,2-dimethylpropyl)aminomethylcycline  0   *Tetracyclines. Nat Rev Drug Discov 2009 Dec;8(12):922
viridicatumtoxin B  0   *Tetracyclines. J Antibiot (Tokyo) 2008 Oct;61(10):633-7
CMT-308  0   *Tetracyclines. Infect Immun 2005 Nov;73(11):7548-57
dichloro(tetracycline)platinum(II)  0   *Organoplatinum Compounds *Tetracyclines. J Inorg Biochem 2005 May;99(5):1001-8
europium(III) tetracycline  0   *Organometallic Compounds *Tetracyclines Europium. Appl Spectrosc. 2003 Nov;57(11):1386-92
CMT-5 compound  0   *Tetracyclines. Am J Pathol 2003 Oct;163(4):1557-66
2-(3-estrone-N-ethyl-piperazine-methyl)tetracycline  0   *Piperazines *Tetracyclines. Acta Pharmacol Sin 2000 Mar;21(3):200-4
2-tetracyclinonitrile  0   *Tetracyclines. Eur J Biochem 2000 Jan;267(2):527-34
tetracycline CMT-2  0   *Tetracyclines. Adv Dent Res 1998 Nov;12(2):144-8; Adv Dent Res 1998 Nov;12(2):159-65
tetracycline CMT-3  0   *Tetracyclines. Adv Dent Res 1998 Nov;12(2):159-65; Adv Dent Res 1998 Nov;12(2):97-102
tetracycline CMT-7  0   *Tetracyclines. Adv Dent Res 1998 Nov;12(2):159-65; Adv Dent Res 1998 Nov;12(2):82-5
tetracycline CMT-8  0   *Tetracyclines. Adv Dent Res 1998 Nov;12(2):159-65; Adv Dent Res 1998 Nov;12(2):76-81
2-acetyl-2-decarboxamidotetracycline  0   *Tetracyclines. J Pharm Biomed Anal 1997 May;15(8):1063-9
2-acetyl-2-decarboxamidooxytetracycline  6542-44-5   *Tetracyclines. J Pharm Biomed Anal 1997 May;15(8):1063-9
GR 33076X  0   *Tetracyclines Tetracycline/antagonists & inhibitors. Nucleic Acids Res 1996 Aug 1;24(15):2900-4
TAN 1518 B  154163-87-8   *Tetracyclines DNA Topoisomerases, Type I/antagonists & inhibitors. J Antibiot (Tokyo) 1994 May;47(5):545-56
TAN 1518 A  154163-86-7   *Tetracyclines DNA Topoisomerases, Type I/antagonists & inhibitors. J Antibiot (Tokyo) 1994 May;47(5):545-56
WS 79089C  157110-25-3   *Tetracyclines. J Antibiot (Tokyo) 1994 Jun;47(6):619-30
WS 79089B  157110-24-2   *Tetracyclines. J Antibiot (Tokyo) 1994 Jun;47(6):619-30
WS 79089A  157110-23-1   *Tetracyclines. J Antibiot (Tokyo) 1994 Jun;47(6):619-30
CL 331002  154445-06-4 2-Naphthacenecarboxamide, 4-(dimethylamino)-N-((dimethylamino)acetyl)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,12aalpha))  *Tetracyclines. Antimicrob Agents Chemother 1994 Mar;38(3):534-41
13-((3-chloropropyl)thio)-5-hydroxy-6-deoxytetracycline  146253-86-3   *Tetracyclines. J Med Chem 1994 Apr 29;37(9):1355-61
13-propylthio-5-hydroxy-6-deoxytetracycline  146277-96-5   *Tetracyclines. J Med Chem 1994 Apr 29;37(9):1355-61
6-demethyl-9-(N,N-dimethylglycylamido)-6-deoxytetracycline  151922-17-7   *Tetracyclines. Antimicrob Agents Chemother 1993 Nov;37(11):2270-7
anthrotainin  148084-40-6 2-Naphthacenecarboxamide, 3,4,4a,5,12,12a-hexahydro-1,4a,10,11,12a-pentahydroxy-8-methoxy-3,12-dioxo-, (cis)  *Tetracyclines. J Antibiot (Tokyo) 1993 Feb;46(2):214-21
SF 2575  126728-71-0 Benzoic acid, 2-hydroxy-, 3-(aminocarbonyl)-8-(2,6-dideoxy-4-O-(2-methyl-1-oxo-2-butenyl)-beta-D-arabino-hexopyranosyl)-1,4,4a,6,11,11a,12,12a-octahydro-2,5,7-trihydroxy-4a,11-dimethoxy-11-methyl-4,6-dioxo-1-naphthacenyl ester, (1R-(1a,4aalpha,11.beta))  *Tetracyclines Streptomyces. J Antibiot (Tokyo) 1992 Mar;45(3):325-30
morphocycline  3098-60-0   *Tetracyclines.
WP 1  0   *Tetracyclines Acetazolamide/*analogs & derivatives. Proc Soc Exp Biol Med 1987;186(1):96
Reboul cocktail  117706-64-6   *Lidocaine *Penicillins *Tetracyclines *Tolazoline Drug Combinations. J Mal Vasc 1986;11(4):388
technetium Tc 99m tetracycline  0   *Tetracyclines *Organotechnetium Compounds. Sov Med 1983;1:52
2-decarboxamido-2-acetyl-4-dedimethyl-9-methyltetracycline  81919-29-1 1,12(4H,5H)-Naphthacenedione, 2-acetyl-4-amino-4a,5a,6,12a-tetrahydro-3,6,10,11,12a-pentahydroxy-6,9-dimethyl-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))  *Tetracyclines. J Antibiot (Tokyo) 1982;35(3):364
thiacycline  59753-24-1   *Tetracyclines. J Antimicrob Chemother 1982;9(6):445
tetracyclinomethylsteptomycin  70614-16-3 D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N3-(aminoiminomethyl)-N1-((((((4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphth  *Tetracyclines Streptomycin/*analogs & derivatives. Indian J Exp Biol 17(3):285;1979
tegralezol  0   *Dibucaine *Fatty Acids, Unsaturated *Tetracyclines Drug Combinations. Vrach Delo (3):92;1979
tetragluxine  0   *Tetracyclines. Inf Dent 51:37;1975
5a,6-anhydrotetracycline  1665-56-1   *Tetracyclines. BBA 518(2):267;1978; J Pharm Sci 1980;69(8):928
4-dedimethylamino-11-methoxyanhydrotetracycline  61695-17-8   *Tetracyclines. J Pharm Sci 64(10):1635;1975
penimocycline  16259-34-0 6-(((((((4-(dimethylamino)-1,4 alpha, 4a alpha,5,5a alpha,6 beta,11,12a alpha-octahydro- 3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenyl)carbonyl)amino)methyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-aza bicyclo(3.2.0)heptane-2  *Tetracyclines Ampicillin/*analogs & derivatives. J Chromatogr 124(2):343;1976; Sem Hop Ther 51(1):19;1975; Sem Hop Ther 51(10):543;1975
7-dimethylamino-6-deoxy-6-demethyltetracycline  0   *Tetracyclines. Antibiotica 11(3-4):134;1973
penimepicycline  4599-60-4   *Penicillin V *Tetracyclines.
lauricycline  5821-53-4   *Tetracyclines.
puricilina  78515-89-6 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))-, compd. with (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentah  *Bromelains *Penicillin V *Tetracyclines Drug Combinations. Prensa Med Argent 59(17):671;1972
prolinomethyltetracycline  37106-99-3   *Tetracyclines. Jpn J Antibiot 24(6):249;1971
oleomorphocycline  18353-77-0   Oleandomycin Tetracyclines. Farmatsiia 27(1):88;1978; Wiad Lek 26(6):509;1973
aminochlorthenoxycycline  40910-00-7   *Oxazines *Tetracyclines.
etamocycline  15590-00-8 2-Naphthacenecarboxamide, N,N'-(1,2-ethanediylbis((methylimino)methylene))bis(4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(2(4R*,4aR*,5aR*,6R*,12aR*),4alpha,4aalpha,5aalpha,6beta,12aalpha)))  *Tetracyclines. Therapeutique 48(7):463;1972
SQ 1205  50836-93-6 (4S-(4 alpha,4a alpha,5a alpha,6 beta,12a alpha))-N-(bis(2-chloroethylamino)(4-hydroxyphenyl)methyl)-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide  *Nitrogen Mustard Compounds *Tetracyclines. Therapie 27(4):601;1972
guamecycline  16545-11-2 N,N-diethyleneiminobiguanidomethyltetracycline  *Tetracyclines.
glycocycline  751-98-4   *Tetracyclines. Antibiotiki 20(5):462;1975
chelocardin  29144-42-1 2-decarboxamido-2-acetyl-4-dedimethylamino-4-epiamino-9- methyl-5a,6-anhydrotetracycline  *Tetracyclines. Antimicrob Ag Chemother 13(4):598;1978; Antimicrob Ag Chemother 9(1):36;1976; J Chromatogr 129:73;1976; Lijec Vjesn 99(9):560;1977

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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