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Thrombopoietin
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Definition
: A humoral factor that stimulates the production of thrombocytes (BLOOD PLATELETS). Thrombopoietin stimulates the proliferation of bone marrow MEGAKARYOCYTES and their release of blood platelets. The process is called THROMBOPOIESIS.
Other names
c-
mpl Ligand; Megakaryocyte Growth and Development Factor; Thrombocytopoiesis Stimulating Factor; Ligand, mpl; Ligand, c-
mpl; mpl Ligand; Thrombocytopoietin; Thrombocytopoiesis-
Stimulating Factor; Myeloproliferative Leukemia Virus Oncogene Ligand; Megakaryocyte Colony Stimulating Factor; MGDF Factor
Substance
CAS Registry & name
Categories
Source
Drugs
*
ALXN4100TPO
0
*Antibodies, Monoclonal
*Thrombopoietin
Receptors, Thrombopoietin/agonists.
Radiat Res. 2011 Jun;175(6):746-58
RWJ 800088
0
*Peptides
Thrombopoietin/antagonists & inhibitors.
Clin Pharmacol Ther 2008 Oct;84(4):481-7
romiplostim
0
*Receptors, Fc
*Recombinant Fusion Proteins
*Thrombopoietin
Receptors, Thrombopoietin/agonists.
Cytokine 2004 Jan 21;25(2):52-60
NPLATE
promegapoietin-
1a
0
*Interleukin-3
*Recombinant Fusion Proteins
*Thrombopoietin.
Stem Cells 2001;19(4):329-38
GW395058
0
*Peptides
Thrombopoietin
Molecular Mimicry.
Stem Cells 1999 ;17(4):203-9
polyethylene glycol-
recombinant human megakaryocyte growth and development factor
0
*Polyethylene Glycols
*Thrombopoietin
Recombinant Proteins.
Blood 1997 Jan 1;89(1):155-65
megapoietin protein, Ovis aries
158254-29-6 Megapoietin
*Thrombopoietin.
Proc Natl Acad Sci U S A 1994 Nov 8;91(23):11104-8
MPL protein, human
143641-95-6
*Receptors, Thrombopoietin
Thrombopoietin.
Embo J 1993 Jul;12(7):2645-53; Proc Natl Acad Sci USA 1992 Jun 15;89(12):5640-4