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Thyrotropin-Releasing Hormone

More information in Books or onNLM PubMed
Definition: A tripeptide that stimulates the release of THYROTROPIN and PROLACTIN. It is synthesized by the neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, TRH (was called TRF) stimulates the release of TSH and PRL from the ANTERIOR PITUITARY GLAND.     
Pharmacological Action Hormones
See Also Receptors, Thyrotropin-Releasing Hormone 		Other names Protirelin Ferring Brand; Protirelin Aventis Brand; Protirelin Abbott Brand; Prem, TRH; Abbott38579; Abbott 38579; Thyrotropin-Releasing Hormone Tartrate; Thyrotropin-Releasing Factor; Thyroliberin TRH Merck; Thypinone; TRH Prem; TRH Ferring; Stimu-TSH; Relefact TRH; Protirelin Tartrate (1:1); Proterelin Tartrate; Novartis Brand of Protirelin; Merck Brand of Protirelin; Henning Berlin Brand of Protirelin; Ferring Brand of ProtirelinDrugs* : THYREL TRH; THYPINONE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
L-pGlu-(1-benzyl)-L-His-L-ProNH2  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Epilepsy Res. 2009 Dec;87(2-3):223-33
pyroglutamyl-(2-propyl)histidyl-prolinamide  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Epilepsy Behav 2009 Jan;14(1):48-53
Glp-asparagine-proline-D-tyrosine-D-tryptophanylamide  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Neurosci Lett. 2008 Jan 24;431(1):26-30
3-(aminocarbonyl)-1-(3-(2-(aminocarbonyl)pyrrolidin-1-yl)-3-oxo-2-(((5-oxopyrrolidin-2-yl)carbonyl)amino)propyl)pyridinium  0   *Pyridinium Compounds Thyrotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 2004 Nov 18;47(24):6025-33
pyroglutamyl-tyrosyl-prolylamide  0   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Neurochem Int 2002 Dec;41(6):415-28
pSE14 protein, rat  0   *Peptide Fragments *Protein Precursors *Thyrotropin-Releasing Hormone. Endocrinology 2001 Feb;142(2):896-906
pFQ7 protein, rat  0   *Peptide Fragments *Protein Precursors *Thyrotropin-Releasing Hormone. Endocrinology 2001 Feb;142(2):896-906
thyrotropin-releasing hormone, Leu(2)-Pip(3)  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Bioorg Med Chem Lett 2000 May;8(5):1059-63
pyroglutamyl-leucyl-prolinamide  0   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 1999 Nov 4;42(22):4572-83
glutaminyl-pyroglutamyl-glutamyl-proline amide  0   Thyrotropin-Releasing Hormone/*analogs & derivatives Pyrrolidonecarboxylic Acid/*analogs & derivatives. Mol Reprod Dev 1998 Dec;51(4):468-76
TA 0910 acid-type  103300-77-2   Thyrotropin-Releasing Hormone/*analogs & derivatives. J Pharm Biomed Anal 1998 Apr;16(8):1267-74
pyroglutamyl-phenylalanyl-prolyl-N-methyl-psi(5-tetrazole)  0   *Oligopeptides Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone. Acta Crystallogr C 1995 Dec 15;51(Pt 12):2575-9
digipramine  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Biull Eksp Biol Med 1994 Aug;118(8):117-9
thyrotropin-releasing hormone, 4(5)-nitroimidazole  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. J Neurotrauma 1993 Summer;10(2):101-8
thyrotropin-releasing hormone, 2,4-diiodoimidazole  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. J Neurotrauma 1993 Summer;10(2):101-8
JTP 2942  148152-77-6 L-Prolinamide, N-((2-methyl-4-oxocyclopentyl)carbonyl)-L-histidyl-, (1S-cis)  Thyrotropin-Releasing Hormone/*analogs & derivatives. Eur J Pharmacol 1993 Mar 16;233(1):21-8
TRH, 4-azidosalicylamide  0   *Azides Thyrotropin-Releasing Hormone/*analogs & derivatives. Biochem J 1992;281(Pt 1):179
protirelin, Nve(2)-Prot(3)  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Gen Physiol Biophys 1991;10(3):287
protirelin, Nle(2)-Prot(3)  0   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Gen Physiol Biophys 1991;10(3):287
thyrotropin-releasing hormone, 2-diazohistidinyl  81222-52-8   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. J Recept Res 1991;11(1-4):371
prepro-thyrotropin releasing hormone (25-50)  0   *Protein Precursors *Thyrotropin-Releasing Hormone. Endocrinology 1991;129(1):556
5-oxoprolyl-4(5)-iodohistidyl-prolinamide  60839-69-2   Thyrotropin-Releasing Hormone/*analogs & derivatives. Peptides 1990;11(5):939
5-oxoprolyl-2,4(5)-diiodohistidyl-prolinamide  55536-96-4   Thyrotropin-Releasing Hormone/*analogs & derivatives. Peptides 1990;11(5):939
TA 0910  103300-74-9   Thyrotropin-Releasing Hormone/*analogs & derivatives.
Pharma Action Nootropic Agents 		J Med Chem 1990;33(8):2130
thyrotropin-releasing hormone, 2,4-MePro(3)  127902-57-2   Thyrotropin-Releasing Hormone/*analogs & derivatives. Biopolymers 1990;29(2):407
prepro-thyrotropin-releasing hormone  100469-84-9 Thyrotropin-releasing factor, prepro  *Protein Precursors *Thyrotropin-Releasing Hormone. Neuropeptides 1990;15(1):49
PR 546  117217-40-0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Fiziol Zh SSSR 1989;75(3):409
thyrotropin-releasing hormone, 1-(methano-Glp(2,3))  120083-46-7   Thyrotropin-Releasing Hormone/*analogs & derivatives. Biopolymers 1989;28(1):123
pyroglutamyl-glutamyl-proline amide  85541-78-2   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. J Biol Chem 1989;264(14):7788
prepro-thyrotropin releasing hormone (53-74)  109796-64-7   *Peptide Fragments *Protein Precursors *Thyrotropin-Releasing Hormone. Brain Res 1988;461(1):53
prepro-thyrotropin-releasing hormone (178-199)  122018-92-2   *Peptide Fragments *Protein Precursors *Thyrotropin-Releasing Hormone. J Biol Chem 1988;263(32):17189
prepro-thyrotropin releasing hormone (160-169)  122018-91-1   *Peptide Fragments *Protein Precursors *Thyrotropin-Releasing Hormone. J Biol Chem 1988;263(32):17189
posatirelin  78664-73-0 L-Prolinamide, N-((6-oxo-2-piperidinyl)carbonyl)-L-leucyl-, (S)  Thyrotropin-Releasing Hormone/*analogs & derivatives. Experientia 1988;44(1):39
pyroglutamyl-histidyl-proline-tyramine  107810-10-6   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Acta Endocrinol (Copenh) 1987;114(2):314
pyroglutamyl-((N3)-imidazolylmethyl)-histidyl-n-amylprolinamide  107810-09-3   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Acta Endocrinol (Copenh) 1987;114(2):314
thyrotropin-releasing hormone, nVal(2)  78058-02-3   Thyrotropin-Releasing Hormone/*analogs & derivatives. Regul Pept 1985;13(1):21
thyrotropin releasing hormone, CRM45  0   *Recombinant Proteins *Thyrotropin-Releasing Hormone. Proc Soc Exp Biol Med 1986;181(1):131
pyroglutamyl-histidyl-proline thioamide  99933-27-4   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Experientia 1985;41(12):1576
pro-thyrotropin releasing hormone  98616-54-7   *Protein Precursors *Thyrotropin-Releasing Hormone Pyrrolidonecarboxylic Acid/*analogs & derivatives. Science 1985;229(4718):1097
thyrotropin-releasing hormone, 4-fluoroimidazole  0   *Thyrotropin-Releasing Hormone. Neuropeptides 1984;4(4):303
thyrotropin-releasing hormone, 2-fluoromethylimidazole  92484-23-6 L-Prolinamide, 5-oxo-L-prolyl-2-(trifluoromethyl)-L-histidyl-, (SP-4-2)  *Thyrotropin-Releasing Hormone. Neuropeptides 1984;4(4):303
thyrotropin-releasing hormone, Gly-Lys-Arg  89455-78-7 L-Arginine, N2-(N2-(N-(1-(N-L-alpha-glutamyl-L-histidyl)-L-prolyl)glycyl)-L-lysyl)  Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. FEBS Lett 1984;167(1):160
thyrotropin-releasing hormone, Gly  85344-77-0   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. FEBS Lett 1984;167(1):160
thyrotropin releasing hormone 5-fluoroimidazole  81222-57-3 L-Prolinamide, 5-oxo-L-prolyl-5-fluoro-L-histidyl  Thyrotropin-Releasing Hormone/*analogs & derivatives. Biochem Biophys Res Commun 1983;113(2):581
CG 3509  62305-86-6   Thyrotropin-Releasing Hormone/*analogs & derivatives. J Neurochem 1982;39(6):1763
2-hydroxy-4-carboxybutyrylhistidylprolinamide  83437-32-5 L-Prolinamide, N-(4-carboxy-2-hydroxy-1-oxobutyl)-L-histidyl  Thyrotropin-Releasing Hormone/*analogs & derivatives. J Immunol Methods 1982;51(1):69
N-(2-hydroxy-4-(isobutylcarbamoyl)butyryl)histidylprolinamide  83437-31-4 L-Prolinamide, N-(2-hydroxy-5-((2-methylpropyl)amino)-1,5-dioxopentyl)-L-histidyl  Thyrotropin-Releasing Hormone/*analogs & derivatives. J Immunol Methods 1982;51(1):69
thyrotropin-releasing hormone, Pro-hydrazide  60548-59-6   Thyrotropin-Releasing Hormone/*analogs & derivatives. Mater Med Pol 1980;12(1-2):129
thyrotropin-releasing hormone, 2-picolyl  0   Thyrotropin-Releasing Hormone/*analogs & derivatives. Endokrynol Pol 1981;32(4):303
montirelin  62305-91-3   Thyrotropin-Releasing Hormone/*analogs & derivatives. Peptides 1981;2(2):131
methyl pyroglutamyl-histidyl-pipecolate  64783-97-7   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 1981;24(6):692
pyro(alpha-aminoadipyl)-histidyl-prolinamide  57884-93-2   Thyrotropin-Releasing Hormone/*analogs & derivatives. J Med Chem 1981;24(6):692
pyroglutamyl-histidyl-3-methylprolinamide  61406-69-7   Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Neuropharmocology 1981;20(5):497
fluorescein-thyrotropin-releasing hormone  77160-98-6 L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-N-(6-((((3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-5-yl)amino)thioxomethyl)amino)hexyl)  *Fluoresceins Thyrotropin-Releasing Hormone/*analogs & derivatives. Proc Natl Acad Sci USA 1981;78(1):587
thyrotropin-releasing hormone, beta-(pyrazolyl-1)-Ala(2)  28398-28-9 L-Prolinamide, 5-oxo-L-prolyl-3-(1H-pyrazol-3-yl)-L-alanyl  Thyrotropin-Releasing Hormone/*analogs & derivatives. Horm Metab Res 1981;13(2):107
DN 1417  77026-80-3 L-Prolinamide, N-((tetrahydro-5-oxo-2-furanyl)carbonyl)-L-histidyl  Thyrotropin-Releasing Hormone/*analogs & derivatives.
Pharma Action Anticonvulsants ; Antipsychotic Agents 		Life Sci 1981;28(8):861
thyrotropin releasing hormone chloromethyl ketone  76819-95-9 2-Pyrrolidinecarboxamide, N-(2-(2-(chloroacetyl)-1-pyrrolidinyl)-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl)-5-oxo-, (2S-(2R*(R*(R*))))  Thyrotropin-Releasing Hormone/*analogs & derivatives. Biochem Biophys Res Commun 1981;98(1):234
thyrotropin releasing hormone diazomethyl ketone  76760-06-0 2-Pyrrolidinecarboxamide, N-(2-(2-(diazoacetyl)-1-pyrrolidinyl)-1-(1H-imidazol-4-ylmethyl)-2-oxoethyl)-5-oxo-, (2S-(2R*(R*(R*))))  Thyrotropin-Releasing Hormone/*analogs & derivatives. Biochem Biophys Res Commun 1981;98(1):234
L-pyroglutamyl-L-histidyl-3,3-dimethylprolinamide  76820-40-1 L-Prolinamide, 5-oxo-L-prolyl-L-histidyl-3,3-dimethyl  Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Neuropharmacology 1980;19(12):1247
thyrotropin-releasing hormone, linear beta-Ala  55536-95-3 beta-alaninamide, 5-oxo-L-prolyl-L-histidyl-L-prolyl  Pyrrolidonecarboxylic Acid/*analogs & derivatives Thyrotropin-Releasing Hormone/*analogs & derivatives. Neuroendocrinology 1980;30(4):193
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