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Tryptophan Hydroxylase
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Definition
: An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the biosynthesis of SEROTONIN.
See Also
Tryptophan Oxygenase
Other names
Tryptophan Monooxygenase; Monooxygenase, Tryptophan; Hydroxylase, Tryptophan
Substance
CAS Registry & name
Categories
Source
Drugs
*
2-
amino-
3-
(4-
(2-
amino-
6-
(2,2,2-
trifluoro-
1-
(3'-
methoxybiphenyl-
4-
yl)ethoxy)-
pyrimidin-
4-
yl)phenyl)propionic acid
0
*Biphenyl Compounds
Phenylalanine/*analogs & derivatives
Tryptophan Hydroxylase/antagonists & inhibitors.
IDrugs 2010 Dec;13(12):921-8
tph1 protein, rat
EC 1.14.16.4
*Tryptophan Hydroxylase.
Eur J Neurosci. 2005 Aug;22(4):895-901
tph2 protein, rat
EC 1.14.16.4
*Tryptophan Hydroxylase.
Eur J Neurosci. 2005 Aug;22(4):895-901
TPH1 protein, human
EC 1.14.16.4
*Tryptophan Hydroxylase
Biological Markers.
Genes Brain Behav. 2004 Dec;3(6):328-36
TPH2 protein, human
EC 1.14.16.4
*Tryptophan Hydroxylase.
Science 2003 Jan 3;299(5603):76
Tph2 protein, mouse
EC 1.14.16.4
*Tryptophan Hydroxylase.
Science 2003 Jan 3;299(5603):76
Tph1 protein, mouse
EC 1.14.16.4
*Tryptophan Hydroxylase.
J Soc Biol 2004;198(1):7-17
p-
ethynylphenylalanine
0
Alanine/*analogs & derivatives
Tryptophan Hydroxylase/antagonists & inhibitors.
J Neurochem 2000 May;74(5):2067-73
AGN 2979
53873-21-5
*Piperidones
Tryptophan Hydroxylase/antagonists & inhibitors.
Biochem Pharmacol 1986;35(9):1521
3,4-
dihydroxystyrene
6053-02-7
*Styrenes
Phenylalanine Hydroxylase/antagonists & inhibitors
Tryptophan Hydroxylase/antagonists & inhibitors
Tyrosine 3-Monooxygenase/antagonists & inhibitors.
Biochim Biophys Acta 1984;789(2):111