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Tyrosine 3-Monooxygenase

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Definition: An enzyme that catalyzes the conversion of L-tyrosine, tetrahydrobiopterin, and oxygen to 3,4-dihydroxy-L-phenylalanine, dihydrobiopterin, and water. EC 1.14.16.2.      Other names Tyrosine 3 Monooxygenase; Hydroxylase, Tyrosine; 3-Monooxygenase, Tyrosine; Tyrosine Hydroxylase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
th2 tyrosine hydroxylase 2, Danio rerio  EC 1.14.16.2   *Tyrosine 3-Monooxygenase *Zebrafish Proteins. Histochem Cell Biol. 2009 Oct;132(4):375-81
catsup protein, Drosophila  0   *Drosophila Proteins Tyrosine 3-Monooxygenase/antagonists & inhibitors. Curr Biol 2006 May 9;16(9):912-9
1-dichloromethylene-1,2,3,4-tetrahydro-beta-carboline  0   *Carbolines Tyrosine 3-Monooxygenase/antagonists & inhibitors. Urol Res 2001 Jun;29(3):814-9
1-trichloromethyl-1,2,3,4-teetrahydro-2-methyl-beta-carboline  0   *Carbolines Tyrosine 3-Monooxygenase/antagonists & inhibitors. J Neurochem 2002 May;81(4):814-9
T14-3c protein, Nicotiana tabacum  EC 1.14.16.-   *Plant Proteins *Tyrosine 3-Monooxygenase. J Biol Chem 2001 Oct 26;276(43):39852-7
3-chlorotyrosine  7298-90-0   Tyrosine/*analogs & derivatives Tyrosine 3-Monooxygenase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		J Pharmacol Exp Ther 1994 May;269(2):709-16
tyrosine hydroxylase (2-16) peptide  0   *Peptide Fragments *Tyrosine 3-Monooxygenase. Proc West Pharmacol Soc 1993;36:273-6
3,4-dihydroxystyrene  6053-02-7   *Styrenes Phenylalanine Hydroxylase/antagonists & inhibitors Tryptophan Hydroxylase/antagonists & inhibitors Tyrosine 3-Monooxygenase/antagonists & inhibitors. Biochim Biophys Acta 1984;789(2):111
pyratrione  51089-21-5   *Pyrones Tyrosine 3-Monooxygenase/antagonists & inhibitors. Clin Sci Med 48(Suppl 2):175s;1978
XK 46  50813-46-2   Streptomyces Tyrosine 3-Monooxygenase/antagonists & inhibitors. J Antibiot (Tokyo) 27(7):502;1974
3-(5-benzimidazolyl)-2-methylalanine  26310-01-0   Alanine/*analogs & derivatives Tyrosine 3-Monooxygenase/antagonists & inhibitors. Biochem Pharm 25(5):585;1976; J Med Chem 17(11):1223;1974
oudenone  31323-50-9   *Cyclopentanes Tyrosine 3-Monooxygenase/antagonists & inhibitors.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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