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Tryptophan Oxygenase

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Definition: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is a LIVER-specific enzyme that is the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.     
See Also Tryptophan Hydroxylase 		Other names Tryptophan Pyrrolase; Tryptophan 2,3 Dioxygenase; Pyrrolase, Tryptophan; Oxygenase, Tryptophan; Dioxygenase, TDO; 2,3-Dioxygenase, Tryptophan; Tryptophan 2,3-Dioxygenase; TDO Dioxygenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methyl-thiohydantoin-tryptophan  0   *Indoles *Thiohydantoins Tryptophan Oxygenase/antagonists & inhibitors. Nat Med 2005 Mar;11(3):312-9
1-methyl-tryptophan  0   Tryptophan/*analogs & derivatives Tryptophan Oxygenase/antagonists & inhibitors. Biochim Biophys Acta 2000 Jan 3;1500(1):119-24
vermilion protein, Drosophila  EC 1.13.11.11   *Eye Proteins *Tryptophan Oxygenase *Drosophila Proteins. Mol Cell Biol 1990 Apr;10(4):1423-31
diethylamine dinitric oxide adduct  92818-79-6   *Diethylamines Tryptophan Oxygenase/antagonists & inhibitors.
Pharma Action Nitric Oxide Donors 		J Biol Chem 1994 May 20;269(20):14457-64
64C87  0   *Organic Chemicals Tryptophan Oxygenase/antagonists & inhibitors. Adv Exp Med Biol 1991;294:281
3-(3-benzofuranylalanine)  72071-49-9   *Benzofurans Alanine/*analogs & derivatives Tryptophan Oxygenase/antagonists & inhibitors. Arch Biochem Biophys 1991;291(2):326
peptide-tryptophan 2,3-dioxygenase  EC 1.13.11.26   *Tryptophan Oxygenase. Eur J Biochem 1986;156(2):317

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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