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Vitamin K

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Definition: A lipid cofactor that is required for normal blood clotting. Several forms of vitamin K have been identified: VITAMIN K 1 (phytomenadione) derived from plants, VITAMIN K 2 (menaquinone) from bacteria, and synthetic naphthoquinone provitamins, VITAMIN K 3 (menadione). Vitamin K 3 provitamins, after being alkylated in vivo, exhibit the antifibrinolytic activity of vitamin K. Green leafy vegetables, liver, cheese, butter, and egg yolk are good sources of vitamin K.  /ther use: coordinate disease with /drug ther, not /diet ther   
Pharmacological Action Antifibrinolytic Agents; Vitamins
Examples Vitamin K 1; Vitamin K 2; Vitamin K 3
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
proline rich Gla (G-carboxyglutamic acid) 2 protein, human  0   *Carrier Proteins *Membrane Proteins Vitamin K. Proc Natl Acad Sci U S A 2007 May 22;104(21):8767-72
2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone  0   Vitamin K/*analogs & derivatives. J Mol Biol 2001 Dec 7;314(4):765-72
2-(2-hydroxyethylsulfanyl)-3-methyl-5-nitro-1,4-naphthoquinone  0   Vitamin K/*analogs & derivatives. J Mol Biol 2001 Dec 7;314(4):765-72
2-(2-hydroxyethylsulfanyl)-3-methyl-5-acetylamino-1,4-naphthoquinone  0   Vitamin K/*analogs & derivatives. J Mol Biol 2001 Dec 7;314(4):765-72
vitamin K2 binding protein, human  0   *Calcium-Binding Proteins *Nuclear Proteins Vitamin K. Biochem Pharmacol 1999 Nov 15;58(10):1631-8
technetium Tc 99m vitamin K4  0   *Vitamin K *Organotechnetium Compounds. Nuclearmedizin 1991;30(1):35
vitamin A, vitamin E, vitamin K3 drug combination  135669-41-9   *Vitamin A *Vitamin E *Vitamin K Drug Combinations. Ortop Travmatol Protez 1989;(1):32
matrix Gla protein  0   *Calcium-Binding Proteins *Extracellular Matrix Proteins Bone and Bones Vitamin K 1-Carboxyglutamic Acid. J Biol Chem 1985;260(28):14971
Ensure Plus  0   *Vitamin K Food, Formulated. Clin Bull 1980;10(4):171
menadiol  481-85-6 2-methyl-1,4-naphthalenediol  Vitamin K/*analogs & derivatives. Biochem J 1980;186(1):309KAPPADIONE; SYNKAYVITE
glutamyl carboxylase  EC 6.4.-   *Carbon-Carbon Ligases Vitamin K. Arch Biochem Biophys 191(2):571;1978; Biochem Biophys Res Commun 83(4):1488;1978; Biochem Biophys Res Commun 86(3):500;1979; Biochemistry 17(8):1371;1978; Biochim Biophys Acta 1980;627(3):225; Biochim Biophys Acta 499:181;1977; Calcif Tissue Int 1980;30(1):73; FEBS Lett 1980;109(2):267; J Biol Chem 1980;255(5):1808; J Biol Chem 251(9):2770;1976; J Biol Chem 254(4):1356;1979; Methods Enzymol 1980;67:165; Methods Enzymol 1980;67:180; Proc Natl Acad Sci USA 75(11):5413;1978; Proc Soc Exp Biol Med 161(4):498;1979; Recent Prog Blood Coag Thromb Res 44:55;1977
antivitamins K  0   *Indenes *4-Hydroxycoumarins Vitamin K/*antagonists & inhibitors.
Pharma Action Anticoagulants 		Bull Soc Sci MedGrande Duche Luxemb 112(2):163;1975
Aesculus, ascorbic acid, hesperidin, vitamin K drug combination  0   *Ascorbic Acid *Hesperidin *Vitamin K *Aesculus Drug Combinations. Pol Tyg Lek 27(47):1862;1972
Pr 112  78456-94-7 Pr 112  *Vitamin E *Vitamin K *Lutein Drug Combinations. Acta Derm Sifiliogr 62(9):411;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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