von Willebrand Factor (definition)

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ψ ψ	von Willebrand Factor

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Definition: A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.

Other names Factor VIII-Related Antigen; Ristocetin Willebrand Factor; Factor VIIIR RCo; Factor VIIIR Ag; Factor VIII Related Antigen; von Willebrand Protein; Ristocetin-Willebrand Factor; Ristocetin Cofactor; Plasma Factor VIII Complex; Factor VIIIR-RCo; Factor VIIIR-Ag

Substance	CAS Registry & name	Categories	Source
ARC15105	0	*Aptamers, Nucleotide von Willebrand Factor/antagonists & inhibitors.	Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):902-9.
optivate	0	Factor VIII von Willebrand Factor Drug Combinations.	Biologicals. 2009 Jan;37(1):26-31.
factor VIII, von Willebrand factor drug combination	0	Factor VIII von Willebrand Factor Drug Combinations.	Haematologica 2004 Sep;89(9):1128-33
factor VIII-von Willebrand factor concentrate 8Y	0	Factor VIII von Willebrand Factor.	Haemophilia 2002 Sep;8(5):622-8
WARP protein, mouse	0	*Extracellular Matrix Proteins von Willebrand Factor.	FEBS Lett 2002 Apr 24;517(1-3):61-6
VWA1 protein, human	0	*Extracellular Matrix Proteins von Willebrand Factor.	FEBS Lett 2002 Apr 24;517(1-3):61-6
saratin	0	*Salivary Proteins and Peptides Recombinant Proteins von Willebrand Factor.	J Vasc Surg 2001 Oct;34(4):724-9
Polydom protein, mouse	0	*Proteins C-Reactive Protein Epidermal Growth Factor von Willebrand Factor Extracellular Matrix Proteins.	Biochem J 2000 Nov 15;352 Pt 1():49-59
S-nitroso-AR545C	0	Peptide Fragments von Willebrand Factor.	Blood 1999 Sep 1;94(5):1693-700
AR545C	0	Peptide Fragments von Willebrand Factor Recombinant Proteins.	Arterioscler Thromb Vasc Biol 1998 Feb;18(2):200-7
ADAMTS13 protein, human	EC 3.4.24.-	*ADAM Proteins von Willebrand Factor.	Blood 1996 May 15;87(10):4223-34
zonadhesin	0	*Membrane Proteins Mucins von Willebrand Factor.	J Biol Chem 1995 Nov 3;270(44):26025-8
hemocytin protein, Bombyx mori	0	Insect Proteins Lectins Factor V Factor VIII Bombyx von Willebrand Factor.	Biochim Biophys Acta 1995 Feb 21;1260(3):245-58
von Willebrand factor (504-728)	0	Peptide Fragments von Willebrand Factor.	Circulation 1994 Dec;90(6):2976-81
von Willebrand factor (445-733)	0	Peptide Fragments von Willebrand Factor Recombinant Proteins.	Biotechnology (N Y) 1993 Jun;11(6):709-13
von Willebrand factor Normandy	0	*von Willebrand Factor.	Proc Natl Acad Sci USA 1991;88(14):6377
von Willebrand factor propolypeptide	0	Protein Precursors von Willebrand Factor.	Cell 1991;64(2):403
prepro-von Willebrand factor	105287-72-7	Protein Precursors von Willebrand Factor.	Nature 1986;324(6094):270
asialo-von Willebrand Factor	0	Asialoglycoproteins von Willebrand Factor/analogs & derivatives.	J Clin Invest 1985;75(1):19
Von Willebrand antigen	0	*von Willebrand Factor/immunology.	Mayo Clin Proc 1981;56(4):243

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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