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Aptamers, Nucleotide

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Definition: Nucleotide sequences, generated by iterative rounds of SELEX APTAMER TECHNIQUE, that bind to a target molecule specifically and with high affinity.      Other names RNA Oligonucleotide Ligands; DNA Oligonucleotide Ligands; Aptamers, RNA; Oligonucleotide Ligands, RNA; Oligonucleotide Ligands, DNA; Nucleotide Aptamers; Aptamers, DNA; RNA Aptamers; DNA Aptamers
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
ARC15105  0   *Aptamers, Nucleotide von Willebrand Factor/antagonists & inhibitors. Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):902-9.
HJ24 aptamer  0   *Aptamers, Nucleotide Protein Tyrosine Phosphatase, Non-Receptor Type 11/antagonists & inhibitors. Chembiochem 2011 Feb 11;12(3):424-30
AP30 aptamer  0   *Aptamers, Nucleotide. Nucleic Acids Symp Ser (Oxf) 2008;(52):493-4
NOX-E36 aptamer  0   *Aptamers, Nucleotide. Nucleic Acids Symp Ser (Oxf) 2008;(52):61-2
NOX-E36-3'PEG, mouse  0   *Aptamers, Nucleotide. Am J Pathol 2008 Mar;172(3):628-37
ARC 1779  0   *Aptamers, Nucleotide. Circulation 2007 Dec 4;116(23):2678-86
NOX-A42  0   *Aptamers, Nucleotide. Neuroreport 2007 Nov 19;18(17):1855-9
RT1t49 aptamer  0   *Aptamers, Nucleotide. Nucleic Acids Res 2007;35(15):5039-50
NOX-C29  0   *Aptamers, Nucleotide. Eur J Pharmacol. 2007 Jul 12;567(1-2):117-24
thrombin aptamer fused adenosine aptamer  0   *Aptamers, Nucleotide. Nucleic Acids Symp Ser (Oxf) 2005;(49):83-4
L-argininamide-binding DNA aptamer  0   *Aptamers, Nucleotide. Biophys Chem 2007 Mar;126(1-3):165-75
d(3'-GGT5'-5'TGGTGTGGTTGG3')  0   *Aptamers, Nucleotide. Nucleic Acids Res 2006;34(22):6653-62
RB 006  0   *Aptamers, Nucleotide Factor IXa/antagonists & inhibitors. Circulation 2006 Dec 5;114(23):2490-7
RA1-HSF aptamer  0   *RNA *Aptamers, Nucleotide. Nucleic Acids Res 2006;34(13) (dup#3):3763-9
NOX-B11-3  0   *Aptamers, Nucleotide. Nucleic Acids Res 2006;34(12):e86
G925-s50 RNA aptamer  0   *RNA *Aptamers, Nucleotide. J Biochem (Tokyo) 2005 Mar;137(3):339-47
NEO-35-s41 RNA aptamer  0   *RNA *Aptamers, Nucleotide. J Biochem (Tokyo) 2005 Mar;137(3):339-47
RNA aptamer B40  0   *RNA *Aptamers, Nucleotide. RNA 2005 Jun;11(6):873-84
RNA aptamer SUP-A-004  0   *RNA *Aptamers, Nucleotide. Nucleic Acids Res 2005;33(4):e45
RNA aptamer 58  0   *RNA *Aptamers, Nucleotide. Nucleic Acids Res 2005;33(2):745-54
pegaptanib  0   *Aptamers, Nucleotide Vascular Endothelial Growth Factor A. N Engl J Med 2004 Dec 30;351(27):2805-16MACUGEN
TTA1 aptamer  0   *Aptamers, Nucleotide. Nucleic Acids Res 2004;32(19) (dup#2);5757-65
cb28 aptamer  0   *Aptamers, Nucleotide. Bioorg Med Chem 2001 Oct;9(10):2549-56
thrombin aptamer  145563-68-4   *Aptamers, Nucleotide Thrombin/antagonists & inhibitors. Blood 1993 Jun 15;81(12):3271-6
defibrotide  83712-60-1   *Polydeoxyribonucleotides Aptamers, Nucleotide.
Pharma Action Fibrinolytic Agents ; Platelet Aggregation Inhibitors 		Pharmacol Res Commun 1982;14(10):949

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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