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7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide

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Definition: 7,8,8a,9a-Tetrahydrobenzo(10,11)chryseno (3,4-b)oxirene-7,8-diol. A benzopyrene derivative with carcinogenic and mutagenic activity.  a carcinogen & mutagen; D25-26 qualif; DF: 7 8 DDBP   
Pharmacological Action Carcinogens; Mutagens 		Other names Benzo(a)pyrene 7,8-Dihydrodiol 9,10-Epoxide; 7,8-Dihydroxy-9,10-Epoxy-7,8,9,10-Tetrahydrobenzo(; Anti BaPDE; Benzo(a)pyrene-7,8-diol 9,10-Epoxide; BPDE; Anti-BaPDE; 7,8-BaP-9,10-Diol Epoxide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
benzo(a)pyrene 7,8-diol-9,10-epoxide-N2-deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Chem Res Toxicol 2000 Oct;13(10):1046-50
glutathione-BPDE conjugate  0   *Glutathione *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide Glutathione Transferase/antagonists & inhibitors Stereoisomerism. Biochem J 1998 Jun 15;332(Pt 3):799-805
1-nitrobenzo(a)pyrene-7,8-diol-9,10-epoxide  88598-54-3   7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Environ Mol Mutagen 1996;27(1):19-29
N(6)-(10-(7,8,9-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrenyl))-2'-deoxyadenosine  0   *Deoxyadenosines 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Biochemistry 1995 Oct 17;34(41):13570-81
10-N(2)-deoxyguanosine-3-nitrobenzo(a)pyrene-7,8,9-triol  62624-73-1   Deoxyguanosine/*analogs & derivatives 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Chem Res Toxicol 1993 Sep-Oct;6(5):603-8
3-nitrobenzo(a)pyrene-7,8-diol-9,10-epoxide  149559-16-0   7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Chem Res Toxicol 1993 Sep-Oct;6(5):603-8
benzo(a)pyrene 7,8-dihydrodiol-9,10-epoxide poly((dA-dC).(dG-dT)) adduct  0   *Polydeoxyribonucleotides *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide. Chem Res Toxicol 1991;4(3):311
benz(a)pyrene-7,8-dihydrodiol-9,10-epoxide poly((dT-dC).(dG-dA)) adduct  0   *Polydeoxyribonucleotides *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide. Chem Res Toxicol 1991;4(3):311
poly(dG-dC)-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide  0   *Polydeoxyribonucleotides *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide. Biopolymers 1990;29(8-9):1249
7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene-DNA adduct  0   *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide *DNA Adducts. Carcinogenesis 1988;9(10):1863
benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA  0   *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide *DNA Adducts. Cancer Res 1985;45(1):66
7,8-dihydroxy-9,10-epoxide-7,8,9,10-tetrahydrobenzo(a)pyrene-10-deoxyguanosine  62698-04-8 Guanosine, 2'-deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo(a)pyren-10-yl)-, (7alpha,8beta,9beta,10alpha)  Deoxyguanosine/*analogs & derivatives 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide/*analogs & derivatives. Science 1984;223(4633):289

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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