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DNA Adducts

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Definition: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.      Other names Adducts, DNA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
O2-(4-(3-pyridyl)-4-oxobut-1-yl)thymidine  0   *Pyridines Thymidine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 2011 Jun 20;24(6):960-7
N2-(4-hydroxyphenyl)guanine  0   Guanine/*analogs & derivatives DNA Adducts Biological Markers. Toxicol Lett 2011 Sep 10;205(3):273-8
1,N2-propano-2'-deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. Chemosphere 2010 Aug;80(9):1081-7
2-amino-6,7,8,9-tetrahydro-9-hydroxypyrido(2,1-f)purine-4(3H)-one  0   Guanine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 2009 Oct;22(10):1728-35
3-ethanesulfonic acid 2'-deoxycytidine  0   *Sulfonic Acids Deoxycytidine/*analogs & derivatives DNA Adducts. Cancer Sci 2008 Sep;99(9):1741-6
N2-ethylidene-2'-deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 2003 Feb;16(2):145-52
2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct  0   *Imidazoles *DNA Adducts. Toxicol Sci 2004 Jul;80(1):109-14
alpha-methyl-gamma-hydroxy-1,N2-propano-2'-deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. Nucleic Acids Res. 2005;33(11) (dup#1):3513-20
3-(2'-deoxy-beta-D-erythro-pentofuranosyl)pyrimido(1,2-alpha)purin-10(3H)-one  0   *Purine Nucleosides DNA Adducts. J Am Chem Soc. 2004 Jul 7;126(26):8237-43
pBQ-dC adduct  0   *DNA Adducts. Nucleic Acids Res 2004;32(9) (dup#2):2844-52
7-(benzo(a)pyren-6-yl)adenine  0   *Benzopyrenes Adenine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 2003 Apr;16(4):479-86
DNA-bipyridyl-(ethylenediamine)platinum(II)  0   *Organoplatinum Compounds *DNA Adducts 2,2'-Dipyridyl/*analogs & derivatives. J Biomol Struct Dyn 2002 Feb;19(4):681-90
C8-2'-deoxyguanosine-2-amino-3-methylimadazo(4,5-f)-quinoline adduct  0   *Quinolines Deoxyguanosine/*analogs & derivatives DNA Adducts. Org Lett 2001 Feb 22;3(4):565-8
alpha-(N(2)-deoxyguanosinyl)tamoxifen N-oxide  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis. 2000 Sep;21(9):1737-44
7-(3-chloro-2-hydroxypropyl)guanine  0   Guanine/*analogs & derivatives DNA Adducts. Carcinogenesis 2000 Feb;21(2):275-80
7-(deoxyguanosin-N(2)--yl)aristolactam II  0   *Aristolochic Acids Deoxyguanosine/*analogs & derivatives DNA Adducts. Carcinogenesis 2000 Feb;21(2):235-42
7-(deoxyadenosin-N(6)--yl)aristolactam II  0   *Deoxyadenosines *Aristolochic Acids DNA Adducts. Carcinogenesis 2000 Feb;21(2):235-42
N(2)-(1-carboxyethyl)deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. Biochem Biophys Res Commun 1999 Oct 22;264(2):544-9
3-((1,3-dihydro-2,4-dioxopyrimidin-5-yl)methyl)tyrosine  0   Thymine/*analogs & derivatives Tyrosine/*analogs & derivatives DNA Adducts. Free Radic Biol Med 1999 Aug;27(3-4):254-61
anti-benzo(a)pyrene-dA adduct  0   *Benzopyrenes *DNA Adducts. Biochemistry 1999 Aug 17;38(33):10831-42
N-7-(1-hydroxy-3-buten-2-yl)guanine  0   Guanine DNA Adducts. Chem Res Toxicol 1999 Jul;12(7):566-74
N-7-(2-hydroxy-3-buten-1-yl)guanine  0   Guanine DNA Adducts. Chem Res Toxicol 1999 Jul;12(7):566-74
N-7-(2,3,4-trihydroxybut-1-yl)guanine  0   Guanine DNA Adducts. Chem Res Toxicol 1999 Jul;12(7):566-74
1,5,6,7,8-pentahydro-5-hydroxy-1-ribofuranosyl-pyrimido(1,2-b)purine-4(4aH)-one  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. J Med Chem 1999 Mar 25;42(6):947-50
N(2)-ethyl-2'-deoxyguanosine triphosphate  0   *Deoxyguanine Nucleotides DNA Adducts. Biochemistry 1999 Jan 19;38(3):929-35
S-(2-(N(2)-guanyl)ethyl)glutathione  0   *DNA Adducts Glutathione/*analogs & derivatives. Chem Res Toxicol 1998 Apr;11(4):311-6
S-(2-(O(6)-guanyl)ethyl)glutathione  0   *DNA Adducts Glutathione/*analogs & derivatives. Chem Res Toxicol 1998 Apr;11(4):311-6
alpha-sulfate tamoxifen  0   Tamoxifen/*analogs & derivatives DNA Adducts. Chem Res Toxicol 1997 Feb;10(2):189-96
3''-hydroxy-1,N(2)-benzetheno-2'-deoxyguanosine  0   Deoxyguanosine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 1997 Feb;10(2):165-71
alpha-(N(2)-deoxyguanosinyl)tamoxifen  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
4-(4-(2-(dimethylamino)ethoxy)phenyl)-3,4-diphenyl-2-(9beta-deoxyribofuranosyl-6-oxopurin-2-ylamino)-3-butene  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
alpha-(N(6)-deoxyadenosinyl)tamoxifen  0   *DNA Adducts Tamoxifen/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):529-43
7-MBADE-N(6)-deoxyadenosine  0   *Deoxyadenosines *DNA Adducts. Carcinogenesis 1997 Mar;18(3):523-9
7-MBADE-N(2)-deoxyguanosine  0   *DNA Adducts Deoxyguanosine/*analogs & derivatives. Carcinogenesis 1997 Mar;18(3):523-9
7-(benzo(a)pyren-6-yl)guanine  0   *Benzopyrenes Guanine/*analogs & derivatives DNA Adducts. Chem Res Toxicol 1996 Sep;9(6):1037-43
3-(2-deoxypentofuranosyl)-3,5,6,7-tetrahydro-6,7-dihydroxy-6-methyl-9H-imidazo(1,2-a)purin-9-one  159062-85-8   *Imidazoles Deoxyguanosine/*analogs & derivatives DNA Adducts. Environ Mol Mutagen 1995;26(4):286-91
alpha-(N6-adenyl)styrene oxide-DNA adduct  0   *DNA Adducts Adenine/*analogs & derivatives. Biochemistry 1995 Oct 31;34(43):14021-36
DNA-(2-amino-3-methylimidazo(4,5-f)quinoline) adduct  0   *Quinolines *DNA Adducts. Carcinogenesis 1995 Oct;16(10):2523-9
carboplatin-DNA adduct  0   *Carboplatin *DNA Adducts. Carcinogenesis 1995 Oct;16(10):2447-53
polycyclic aromatic hydrocarbons-DNA adduct  0   *Polycyclic Hydrocarbons, Aromatic *DNA Adducts. Mol Carcinog 1995 Sep;14(1):63-8
DNA-lysine adduct  0   *DNA Adducts Lysine/*analogs & derivatives. J Photochem Photobiol B 1995 Feb;27(2):109-15
3-(2'-deoxyribofuranosyl)pyrimido(1,2-a)purin-10(3H)-one  87171-83-3   Deoxyguanosine/*analogs & derivatives DNA Adducts. Science 1994 Sep 9;265(5178):1580-2
N-hydroxy-2-naphthylamine DNA adduct  0   *DNA Adducts 2-Naphthylamine/*analogs & derivatives. Anal Biochem 1994 May 15;219(1):121-30
porfiromycin-DNA adduct  0   *Porfiromycin *DNA Adducts. Mol Pharmacol 1993 Jun;43(6):863-9
aflatoxin B1-DNA adduct  0   *Aflatoxin B1 *DNA Adducts. In Vivo 1989 Nov-Dec;3(6):389-92
dibenz(a,j)anthracene-DNA adduct  0   *Benz(a)Anthracenes *DNA Adducts. Chem Res Toxicol 1991;4(1):115
alpha-naphthoflavone-DNA adduct  0   *Benzoflavones *DNA Adducts. Carconogenesis 1991;12(3):385
diethylstilbesterol-DNA adduct  0   *Diethylstilbestrol *DNA Adducts. Carcinogenesis 1991;12(3):385
1,2-cyclohexanediamine platinum(II)-DNA complex  0   *Organoplatinum Compounds *DNA Adducts. Biochim Biophys Acta 1990;1049(3):298
4-hydroxyaminoquinoline-1-oxide-DNA adduct  0   *DNA Adducts 4-Hydroxyaminoquinoline-1-oxide/*analogs & derivatives. J Invest Dermatol 1989;92(5 Suppl):275S
7,12-dimethylbenz(a)anthracene-DNA adduct  0   *DNA Adducts 9,10-Dimethyl-1,2-benzanthracene/*analogs & derivatives. Carcinogenesis 1989;10(5):823
alachlor-DNA adduct  0   *Acetamides *DNA Adducts. Life Sci 1988;43(25):2087
8-methoxypsoralen-DNA  0   *Methoxsalen *DNA Adducts. Cancer Res 1988;48(24 Pt 1):7013
cisplatin-DNA adduct  0   *Cisplatin *DNA Adducts. Carcinogenesis 1988;9(10):1909
7,8-dihydroxy-9,10-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene-DNA adduct  0   *7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide *DNA Adducts. Carcinogenesis 1988;9(10):1863
benz(a)anthracene-DNA adduct  0   *Benz(a)Anthracenes *DNA Adducts. J Clin Invest 1988;82(1):145
chrysene-DNA adduct  0   *Chrysenes *DNA Adducts. J Clin Invest 1988;82(1):145
benzo(a)pyrene-DNA adduct  0   *Benzo(a)pyrene *DNA Adducts.
Pharma Action Carcinogens, Environmental 		J Clin Invest 1988;82(1):145
psoralen-DNA adduct  0   *Psoralens *DNA Adducts. Biochemistry 1988;27(9):3210
mitomycin C-DNA adduct  0   *Mitomycin *DNA Adducts. Biochemistry 1988;27(9):3182
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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