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HIV Protease

More information in Books or onNLM PubMed
Definition: Enzyme of the human immunodeficiency virus that is required for post-translational cleavage of gag and gag-pol precursor polyproteins into functional products needed for viral assembly. HIV protease is an aspartic protease encoded by the amino terminus of the pol gene.      Other names HTLV-III Protease; HIV Proteinase; Protease, HTLV-III; Protease, HIV; HTLV III Protease; HIV p16 protease; p16 pol gene product, HIV; p16 protease, HIV
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
hexahydro-2H-furo(2,3-b)pyran-4-yl-(2S,3R)-4-(N-isobutyl-4-methoxyphenylsulfonamido)-3-hydroxy-1-phenylbutan-2-yl carbamate  0   *Carbamates *Sulfonamides HIV Protease. J Med Chem 2011 Jan 27;54(2):622-34
methyl 1-(4-Hydroxy-5-(2-(3-((6-(2-hydroxypropan-2-yl)pyridin-2-yl)methyl)-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate  0   *Carbamates Putrescine/*analogs & derivatives HIV Protease. J Med Chem 2009 Apr 23;52(8):2571-86
(1-(N'-(4-hydroxy-4-(2-hydroxyindan-1-ylcarbamoyl)-5-phenylpentyl)-N'-(4-pyridin-4-ylbenzyl)hydrazinocarbonyl)-2,2-dimethylpropyl)carbamic acid methyl ester  0   *Carbamates *Hydrazines HIV Protease. J Med Chem 2008 Feb 28;51(4):1053-7
methyl 1-(5-(2-(3-benzyl-2-oxoimidazolidin-1-yl)-3,3-dimethylbutanamido)-4-hydroxy-6-phenyl-1-(4-(pyridin-2-yl)phenyl)hexan-2-ylamino)-3,3-dimethyl-1-oxobutan-2-ylcarbamate  0   *Dipeptides *Pyridines HIV Protease. J Org Chem 2006 Jul 7;71(14):5369-72
3-(3-acetylphenyl)-N-(1-benzyl-2-hydroxy-3-(isobutyl((4-methoxyphenyl)sulfonyl)amino)propyl)-2-oxooxazolidine-5-carboxamide  0   *Oxazoles *Sulfonamides HIV Protease. J Med Chem 2006 Dec 14;49(25):7342-56
p16 protease, Human immunodeficiency virus 1  EC 3.4.23.-   *HIV Protease.
RO1 compound  0   *Dipeptides HIV Protease. Antimicrob Agents Chemother 2006 Apr;50(4):1518-21
N-(2''-hydroxy-2''-(4-hydroxy-16-oxo-7,8,9,10,11,12,13,14,15,16-decahydro-6H-5-oxa-15-azabenzocyclotetradecen-14-yl)ethyl)-N-isobutyl-4-methoxybenzenesulfonamide  0   *Lactams *Sulfonamides HIV Protease/antagonists & inhibitors. J Med Chem 2005 May 19;48(10):3576-85
hinnuliquinone  0   *Indoles *Benzoquinones HIV Protease/antagonists & inhibitors. Biochem Biophys Res Commun 2004 Nov 5;324(1):108-13
tetrahydrofuranylcarbamatemonopyrrolinone  0   *Carbamates *Pyrroles HIV Protease/antagonists & inhibitors. J Med Chem 2003 May 8;46(10):1831-44
HIV-1 protease (89-99)  0   *Peptide Fragments *HIV Protease. Int J Pept Protein Res 1992 Sep-Oct;40(3-4):180-93
HIV-1 protease (44-48)  0   *Peptide Fragments *HIV Protease. Int J Pept Protein Res 1992 Sep-Oct;40(3-4):180-93
N(alpha)-benzoyl-arginyl-glycyl-phenylalanyl-prolyl-methoxy-beta-naphthylamide  123712-62-9   *Oligopeptides HIV Protease. Anal Biochem 1992 Jan;200(1):143-8
p16 protease, Human immunodeficiency virus 2  EC 3.4.23.-   *HIV Protease. J Biol Chem 1990;265(23):13890

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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