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Ribonucleoprotein, U4-U6 Small Nuclear

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Definition: A nuclear RNA-protein complex that plays a role in RNA processing. In the nucleoplasm, the U4-U6 snRNP along with the U5 snRNP preassemble into a single 25S particle that binds to the U1 and U2 snRNPs and the substrate to form mature SPLICEOSOMES. There is also evidence for the existence of individual U4 or U6 snRNPs in addition to their organization as a U4-U6 snRNP.      Other names U6 snRNP; U6 Small Nuclear Ribonucleoproteins; U4-U6 snRNP; U4-U6 Small Nuclear Ribonucleoproteins; U4 snRNP; U4 Small Nuclear Ribonucleoproteins; Small Nuclear Ribonucleoproteins, U6; Small Nuclear Ribonucleoproteins, U4-U6; Small Nuclear Ribonucleoproteins, U4; Ribonucleoproteins, U6 Small Nuclear; Ribonucleoproteins, U4 Small Nuclear; U4 U6 Small Nuclear Ribonucleoproteins; Small Nuclear Ribonucleoproteins, U4 U6; Ribonucleoprotein, U4 U6 Small Nuclear; Ribonucleoproteins, Small, U4-U6
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Naa38 protein, mouse  EC 2.3.1.88   *Acetyltransferases *Ribonucleoprotein, U4-U6 Small Nuclear.
LACHESIS protein, Arabidopsis  0   *Ribonucleoprotein, U4-U6 Small Nuclear *Arabidopsis Proteins. Development. 2012 Feb;139(3):498-502.
Prpf3 protein, mouse  0   *Ribonucleoprotein, U4-U6 Small Nuclear. Invest Ophthalmol Vis Sci 2008 Sep;49(9):3830-8
Prp3 protein, Drosophila  0   *Nuclear Proteins *Ribonucleoprotein, U4-U6 Small Nuclear *Drosophila Proteins RNA Splicing.
PRP3 protein, S cerevisiae  0   *Nuclear Proteins *Ribonucleoprotein, U4-U6 Small Nuclear *Saccharomyces cerevisiae Proteins RNA Splicing.
PRPF4B protein, human  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Ribonucleoprotein, U4-U6 Small Nuclear.
Prpf4b protein, mouse  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Ribonucleoprotein, U4-U6 Small Nuclear.
PRPF4 protein, human  0   *Ribonucleoprotein, U4-U6 Small Nuclear RNA Splicing.
prp4 protein, S pombe  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Ribonucleoprotein, U4-U6 Small Nuclear *Schizosaccharomyces pombe Proteins.
NAA38 protein, human  0   *Acetyltransferases *Ribonucleoprotein, U4-U6 Small Nuclear. EMBO J 1998 Dec 15;17(24):7442-53
PRPF3 protein, human  0   *Nuclear Proteins *Ribonucleoprotein, U4-U6 Small Nuclear RNA Splicing. Antonie Van Leeuwenhoek 2000 Jan;77(1):65-9; RNA 1997 Aug;3(8):926-41
LSM4 protein, S cerevisiae  0   *Ribonucleoprotein, U4-U6 Small Nuclear *Saccharomyces cerevisiae Proteins. EMBO J 1995 May 1;14(9):2066-75
SNRNP27 protein, human  0   *Ribonucleoprotein, U4-U6 Small Nuclear. J Gen Virol 1994 Oct;75(Pt 10):2625-33
PRP4 protein, S cerevisiae  EC 2.7.1.37   *Protein-Serine-Threonine Kinases *Ribonucleoprotein, U4-U6 Small Nuclear *Saccharomyces cerevisiae Proteins RNA Splicing. Nucleic Acids Res 1993 Aug 25;21(17):4079-83
PRP8 protein, S cerevisiae  0   *Ribonucleoprotein, U4-U6 Small Nuclear *Ribonucleoprotein, U5 Small Nuclear *Saccharomyces cerevisiae Proteins. EMBO J 1992 Oct;11(10):3721-9
PRP6 protein, S cerevisiae  0   *Ribonucleoprotein, U4-U6 Small Nuclear *Ribonucleoprotein, U5 Small Nuclear *Saccharomyces cerevisiae Proteins. Embo J 1990;9(9):2775

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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