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Proto-Oncogene Proteins c-bcl-2

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Definition: Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.     
Examples bcl-Associated Death Protein; bcl-2-Associated X Protein; bcl-2 Homologous Antagonist-Killer Protein; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein 		Other names c-bcl-2, Proto-Oncogene Proteins; c bcl 2 Proteins; bcl 2 Proto Oncogene Proteins; Proto-Oncogene Proteins, bcl-2; Proto Oncogene Proteins c bcl 2; B Cell Leukemia 2 Family Proteins; B-Cell Leukemia 2 Family Proteins; bcl-2 Proto-Oncogene Proteins; c-bcl-2 Proteins
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
6,6',7,7'-tetrahydroxy-3,3'-dimethyl-5,5'-bis(4-methylphenethyl)-2,2'-binaphthyl-1,1',4,4'-tetraone  0   *Naphthoquinones Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. J Med Chem 2010 Nov 25;53(22):8000-11
meiogynin A  0   *Sesquiterpenes Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. J Nat Prod. 2009 Mar 27;72(3):480-3
Bcl2l12 protein, mouse  0   *Proto-Oncogene Proteins c-bcl-2. Proc Natl Acad Sci U S A 2009 Jul 28;106(30):12448-52
Noxa protein, rat  0   *Proto-Oncogene Proteins c-bcl-2. Mamm Genome 2009 Jan;20(1):43-52
TM 179  0   *Benzothiazoles Pyrogallol/*analogs & derivatives Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. J Med Chem 2008 Feb 28;51(4):717-20
ABT 263  0   *Aniline Compounds *Sulfonamides Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. Pediatr Blood Cancer 2008 Jun;50(6):1181-9
TW-37 compound  0   *Benzamides *Sulfones Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors. J Med Chem 2006 Oct 19;49(21):6139-42
BOK protein, human  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis. Cell Mol Life Sci. 2005 May;62(9):1015-24
ABT-737  0   *Biphenyl Compounds *Nitrophenols *Sulfonamides Piperazines Proto-Oncogene Proteins c-bcl-2. Nature 2005 Jun 2;435(7042):677-81
PMAIP1 protein, human  0   *Proto-Oncogene Proteins c-bcl-2.
BCL2L2 protein, human  0   *Apoptosis Regulatory Proteins Apoptosis Proto-Oncogene Proteins c-bcl-2.
Bcl2l2 protein, rat  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis.
Bnip1 protein, rat  0   *Proto-Oncogene Proteins c-bcl-2.
Bfk protein, mouse  0   *Proto-Oncogene Proteins c-bcl-2. Cell Death Differ. 2003 Feb;10(2):185-92
Bfk protein, human  0   *Proto-Oncogene Proteins c-bcl-2. Cell Death Differ. 2003 Feb;10(2):185-92
Buffy protein, Drosophila  0   *Proto-Oncogene Proteins c-bcl-2 *Drosophila Proteins Apoptosis. EMBO J 2003 Jul 15;22(14):3568-79
Bcl-2psi protein, human  0   *Proto-Oncogene Proteins c-bcl-2 Biological Markers. Biochem Biophys Res Commun 2003 Jul 11;306(4):912-7
Bcl-2 protein, Human herpesvirus 8  0   *Viral Proteins *Oncogene Proteins Proto-Oncogene Proteins c-bcl-2. Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3428-33
bhp2 protein, Geodia cydonium  0   *Proto-Oncogene Proteins c-bcl-2 Porifera. Cell Death Differ 2001 Sep;8(9):887-98
BCL2L13 protein, human  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis. J Biol Chem 2001 Jun 1;276(22):19548-54
BCL2L12 protein, human  0   *Muscle Proteins *Proto-Oncogene Proteins c-bcl-2. Genomics 2001 Mar 1;72(2):217-21
BCL2L14 protein, human  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis. J Biol Chem 2001 Jan 26;276(4):2780-5
Pmaip1 protein, mouse  0   *Proto-Oncogene Proteins c-bcl-2. Science 2000 May 12;288(5468):1053-8
BNIP1 protein, human  0   *Proto-Oncogene Proteins c-bcl-2. FEBS Lett 1999 Apr 1;448(1):23-7
Nr13 protein, chicken  0   *Proto-Oncogene Proteins c-bcl-2 *Avian Proteins Apoptosis. Genes Dev 1999 Mar 15;13(6):718-28
BCL2-like 10 protein  0   *Proto-Oncogene Proteins c-bcl-2 Cell Death. EMBO J 1999 Jan 4;18(1):167-78; J Biol Chem 1998 Dec 4;273(49):32479-86
Bax-associated protein P16, mouse  0   *Carrier Proteins Proto-Oncogene Proteins c-bcl-2. J Immunol 1998 Aug 1;161(3):1176-82
Bok protein, mouse  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis. J Biol Chem 1998 Apr 10;273(15):8705-10
Biklk protein, mouse  0   *Mitochondrial Proteins *Adaptor Proteins, Signal Transducing Apoptosis Proto-Oncogene Proteins c-bcl-2. J Biol Chem 1998 Apr 3;273(14):7783-6
Bcl2l2 protein, mouse  0   *Proteins Apoptosis Proto-Oncogene Proteins c-bcl-2. Dev Biol 2001 Nov 15;239(2):295-308; Oncogene 1996 Aug 15;13(4):665-75
BCL2-related protein A1  0   *Proto-Oncogene Proteins c-bcl-2 Apoptosis. Oncogene 1995 Nov 2;11(9):1693-8
Ced-9 protein, C elegans  0   *Proto-Oncogene Proteins c-bcl-2 *Caenorhabditis elegans Proteins. Nature 1994 May 26;369(6478):318-20
myeloid cell leukemia sequence 1 protein  0   *Proto-Oncogene Proteins c-bcl-2. Proc Natl Acad Sci USA 1993 Apr 15;90(8):3516-20

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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