Vasospasm (definition)

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ψ ψ	Vasospasm, Intracranial

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Definition: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).

Other names Vasospasms, Intracranial; Vasospasms, Cerebral; Vasospasm, Cerebral; Vascular Spasms, Intracranial; Vascular Spasm, Intracranial; Spasms, Intracranial Vascular; Spasms, Cerebrovascular; Spasms, Cerebral Artery; Spasm, Intracranial Vascular; Spasm, Cerebrovascular; Spasm, Cerebral Artery; Intracranial Vasospasms; Intracranial Vascular Spasms; Intracranial Angiospasms; Cerebrovascular Spasms; Cerebral Vasospasms; Cerebral Artery Spasms; Cerebral Angiospasms; Artery Spasms, Cerebral; Artery Spasm, Cerebral

Substance	CAS Registry & name	Categories	Source
clazosentan	180384-56-9 N-(6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(2-(1H-tetrazol-5-yl)pyridin-4-yl)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide	Dioxanes Pyridines Pyrimidines Sulfonamides *Tetrazoles Vasospasm, Intracranial Receptor, Endothelin A.	J Pharmacol Exp Ther 1997 Dec;283(3):1110-18

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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Vasospasm, Intracranial