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cdc25 Phosphatases

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Definition: A subclass of dual specificity phosphatases that play a role in the progression of the CELL CYCLE. They dephosphorylate and activate CYCLIN-DEPENDENT KINASES.  do not confuse with CDC25 GUANINE NUCLEOTIDE EXCHANGE FACTOR    Other names Phosphatases, cdc25; Phosphatase, cdc25C; Phosphatase, cdc25B; Phosphatase, cdc25A; Phosphatase, cdc25; M Phase Inducer Phosphatase 3; M Phase Inducer Phosphatase 2; M Phase Inducer Phosphatase 1; cdc25C Phosphatase; cdc25B Phosphatase; cdc25A Phosphatase; cdc25 Phosphatase; M-Phase Inducer Phosphatase 3; M-Phase Inducer Phosphatase 2; M-Phase Inducer Phosphatase 1; Dual Specificity Phosphatase Cdc25C; Dual Specificity Phosphatase Cdc25B; Dual Specificity Phosphatase Cdc25A; Cell Division Cycle 25B protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-(2,5-difluorophenyl)-6-((3-(methyl(3-((2-methyl-4,7-dioxo-4,7-dihydro-1,3-benzothiazol-5-yl)amino)propyl)amino)propyl)amino)-1,3-benzoxazole-4,7-dione  0   *Benzoxazoles *Benzothiazoles cdc25 Phosphatases/antagonists & inhibitors. Int J Cancer 2009 Mar 15;124(6):1449-56
CDC-25.1 protein, C elegans  EC 3.1.3.48   *cdc25 Phosphatases *Caenorhabditis elegans Proteins. Dev Biol 1999 Feb 1;206(1):15-32
Cdc25C phosphatase (211-221)  0   *Peptide Fragments *cdc25 Phosphatases. Biochim Biophys Acta 2004 Jul 23;1693(1):47-55
Cdc25c protein, mouse  EC 3.1.3.48   *cdc25 Phosphatases.
CDC25C protein, human  EC 3.1.3.48   *cdc25 Phosphatases.
CDC25B protein, human  EC 3.1.3.16   *cdc25 Phosphatases.
Cdc25a protein, rat  EC 3.1.3.48   *cdc25 Phosphatases.
Cdc25b protein, mouse  EC 3.1.3.48   *cdc25 Phosphatases.
Cdc25a protein, mouse  EC 3.1.3.16   *cdc25 Phosphatases.
CDC25A protein, human  EC 3.1.3.48   *cdc25 Phosphatases.
arsenate reductase 2, Arabidopsis  EC 1.-   *Multienzyme Complexes *Oxidoreductases *cdc25 Phosphatases *Arabidopsis Proteins. Proc Natl Acad Sci U S A 2006 Apr 4;103(14):5413-8
BN 82685  0   *Thiazoles *Benzoquinones cdc25 Phosphatases/antagonists & inhibitors. Mol Cancer Ther 2005 Sep;4(9):1378-87
TPY-835  0   *Pyrazoles cdc25 Phosphatases/antagonists & inhibitors. Cancer Sci 2005 Sep;96(9):614-9
2,3-bis(2-hydroxyethylsulfanyl)-(1,4)-5,8-dihydroxynaphthoquinone  0   *Naphthoquinones cdc25 Phosphatases/antagonists & inhibitors. Mol Cancer Ther 2005 Apr;4(4):595-602
2,3-bis(2-hydroxyethylsulfanyl)-(1,4)-5-hydroxynaphthoquinone  0   *Naphthoquinones cdc25 Phosphatases/antagonists & inhibitors. Mol Cancer Ther 2005 Apr;4(4):595-602
2,3-bis(2-hydroxyethylsulfanyl)-(1,4)naphthoquinone  0   *Naphthoquinones cdc25 Phosphatases/antagonists & inhibitors. Mol Pharmacol 2002 Apr;61(4):720-8
coscinosulfate  0   *Terpenes cdc25 Phosphatases/antagonists & inhibitors. J Org Chem 2001 Nov 2;66(22):7263-9
NSC 663284  0   *Quinones *Quinolones cdc25 Phosphatases/antagonists & inhibitors. J Med Chem 2001 Nov 22;44(24):4042-9
Cdc25A protein, Xenopus  0   *cdc25 Phosphatases *Xenopus Proteins. Gene 1996 Oct 31;178(1-2):111-4

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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