Definition: Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
Other names Integrin Heterodimer alpha4beta1; CD49d-CD29; alpha4beta1, Integrin Heterodimer; alpha4beta1, Integrin; Very Late Antigen 4; Very Late Activation Antigen 4; Late Antigen-4, Very; Integrin, alpha4beta1; Heterodimer alpha4beta1, Integrin; Antigen-4, Very Late; alpha4beta1 Integrin; Very Late Antigen-4; Very Late Activation Antigen-4; VLA-4; Integrin alpha(4)beta(1)