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JNK Mitogen-Activated Protein Kinases

More information in Books or onNLM PubMed
Definition: A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION.  note specifics   
Examples Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinase 10 		Other names jun NH2 Terminal Kinases; jun NH2 Terminal Kinase; c jun N Terminal Kinase; c jun Amino Terminal Kinase; N-Terminal Kinase, c-jun; JNK Mitogen Activated Protein Kinases; Amino-Terminal Kinase, c-jun; jun-NH2-Terminal Kinases; jun-NH2-Terminal Kinase; c-jun N-Terminal Kinase; c-jun Amino-Terminal Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
4-(9-(tetrahydrofuran-3-yl))-8-(2,4,6-trifluorophenylamino)-9H-purin-2-ylaminocyclohexan-1-ol  0   *Cyclohexanols *Purines JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. Am J Nephrol. 2011;34(4):337-46.
Tat-JBD peptide  0   *Peptides JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. Neuroscience 2006 May 12;139(2):609-27
5-(5-nitrothiazol-2-ylthio)-1,3,4-thiadiazol-2-amine  0   *Thiadiazoles JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. J Med Chem 2009 Apr 9;52(7):1943-52
CC 401  0   *Pyrazolones JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors. Transplantation 2004 Aug 15;78(3):324-32
KGB-1 protein, C elegans  EC 2.7.1.37   *Caenorhabditis elegans Proteins *JNK Mitogen-Activated Protein Kinases. Dev Biol 2002 Nov 15;251(2):333-47
c-jun N-terminal kinase Bim(EL), rat  EC 2.7.1.37   *JNK Mitogen-Activated Protein Kinases Apoptosis. J Neurosci 2004 Oct 6;24(40):8762-70

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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