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Receptors, Prostaglandin E, EP4 Subtype
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Definition
: A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLATE CYCLASE. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.
Other names
Receptors, Prostaglandin EP4; Receptor EP4, Prostanoid; Prostaglandin EP4 Receptor; EP4, Prostanoid Receptor; EP4 Receptors, Prostaglandin; EP4 Receptor, Prostaglandin; Receptor, Prostaglandin EP4; Prostanoid Receptor EP4; Prostaglandin EP4 Receptors; Prostaglandin E2 Receptor, EP4 Subtype; Prostaglandin E Receptor 4; PGE Receptor, EP4 Subtype
Substance
CAS Registry & name
Categories
Source
Drugs
*
17,18,19,20-
tetranor-
16-
(3-
biphenyl)-
2,3,13,14-
tetradehydroprostaglandin E1
0
Alprostadil/*analogs & derivatives
Receptors, Prostaglandin E, EP4 Subtype/agonists.
J Cardiovasc Pharmacol 2011 Mar;57(3):365-72
ONO AE1-
329
0
*Cyclopentanes
*Thioglycolates
Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors.
Eur J Immunol 2011 Aug;41(8):2379-89
MF 592
0
*Indoles
*Sulfonylurea Compounds
Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors.
Bioorg Med Chem Lett 2011 Feb 1;21(3):1041-6
Ptger4 protein, rat
0
*Receptors, Prostaglandin E, EP4 Subtype.
Ptger4 protein, mouse
0
*Receptors, Prostaglandin E, EP4 Subtype.
PTGER4 protein, human
0
*Receptors, Prostaglandin E, EP4 Subtype.