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Receptors, Prostaglandin E, EP4 Subtype

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Definition: A subtype of prostaglandin E receptors that specifically couples to GS ALPHA GTP-BINDING PROTEIN SUBUNITS and subsequently activates ADENYLATE CYCLASE. The receptor may also signal through the activation of PHOSPHATIDYLINOSITOL 3-KINASE.      Other names Receptors, Prostaglandin EP4; Receptor EP4, Prostanoid; Prostaglandin EP4 Receptor; EP4, Prostanoid Receptor; EP4 Receptors, Prostaglandin; EP4 Receptor, Prostaglandin; Receptor, Prostaglandin EP4; Prostanoid Receptor EP4; Prostaglandin EP4 Receptors; Prostaglandin E2 Receptor, EP4 Subtype; Prostaglandin E Receptor 4; PGE Receptor, EP4 Subtype
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
17,18,19,20-tetranor-16-(3-biphenyl)-2,3,13,14-tetradehydroprostaglandin E1  0   Alprostadil/*analogs & derivatives Receptors, Prostaglandin E, EP4 Subtype/agonists. J Cardiovasc Pharmacol 2011 Mar;57(3):365-72
ONO AE1-329  0   *Cyclopentanes *Thioglycolates Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors. Eur J Immunol 2011 Aug;41(8):2379-89
MF 592  0   *Indoles *Sulfonylurea Compounds Receptors, Prostaglandin E, EP4 Subtype/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Feb 1;21(3):1041-6
Ptger4 protein, rat  0   *Receptors, Prostaglandin E, EP4 Subtype.
Ptger4 protein, mouse  0   *Receptors, Prostaglandin E, EP4 Subtype.
PTGER4 protein, human  0   *Receptors, Prostaglandin E, EP4 Subtype.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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