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Betaine

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Definition: A naturally occurring compound that has been of interest for its role in osmoregulation. As a drug, betaine hydrochloride has been used as a source of hydrochloric acid in the treatment of hypochlorhydria. Betaine has also been used in the treatment of liver disorders, for hyperkalemia, for homocystinuria, and for gastrointestinal disturbances. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1341)     
Pharmacological Action Gastrointestinal Agents; Lipotropic Agents 		Other names Oxyneurine; Lycine; Stea16; Scorbob+¬ta+»ne; Scorbo b+¬ta+»ne; Hydrochloride, Betaine; Betaine, Glycine; Betaine Orphan Brand; AcidinPepsin; Acidin Pepsin; UPSA Brand of Betaine Citrate; Stea-16; Scorbo-b+¬ta+»ne; Orphan Brand of Betaine; Novobetaine; Logeais Brand of Betaine Cyclobutyrate; Hepastyl; Glycine Betaine; Fournier Brand of Betaine Ascorbate and Hydrate; CystadaneDrugs* : CYSTADANE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1-methyl-8-oxyquinolinium betaine  0   Betaine/*analogs & derivatives. J Phys Chem B. 2011 Oct 27;115(42):12076-84
amidosulfobetaine-16  0   Betaine/*analogs & derivatives. Langmuir. 2011 Jul 5;27(13):8248-56
chitosan N-betainate  0   Betaine/*analogs & derivatives Chitosan/*analogs & derivatives. Int J Pharm2009 Oct 20;381(1):19-24
pyridinium-barbiturate-betaine dye  0   *Pyridinium Compounds Betaine/*analogs & derivatives. Angew Chem Int Ed Engl. 2009;48(40):7440-3
norzooanemonine  0   Betaine/*analogs & derivatives Alkaloids. Org Biomol Chem. 2008 Jan 21;6(2):287-95
rac-dysibetaine CPa  0   *Cyclopropanes Betaine/*analogs & derivatives. J Org Chem 2007 Dec 7;72(25):9802-3
dimethylthetin  0   Betaine/*analogs & derivatives Glycine/*analogs & derivatives. Exp Toxicol Pathol 2007 Apr;58(5):285-90
3,3'-di(gamma-sulfopropyl)-4,5,4',5'-dibenzo-9-ethylthiacarbocyanine betaine pyridinium salt  0   *Carbocyanines Betaine/*analogs & derivatives. Anal Biochem. 2007 Feb 15;361(2):183-9
decyl betainate  0   *Alkanes Betaine/*analogs & derivatives. Langmuir. 2005 Sep 13;21(19):8658-63
polycarboxybetaine methacrylate  0   *Betaine *Polymethacrylic Acids. Biomacromolecules 2006 Dec;7(12):3311-5
dodecyl betainate  0   Betaine/*analogs & derivatives. J Colloid Interface Sci. 2004 Oct 15;278(2):478-87
echinobetaine B  0   Betaine/*analogs & derivatives. Org Biomol Chem. 2005 Jan 7;3(1):118-22
amidosulfobetaine-14  0   Betaine/*analogs & derivatives. J Proteome Res. 2005 Sep-Oct;4(5):1848-54
cocoamidopropylbetaine  0   Betaine/*analogs & derivatives. Acta Crystallogr D Biol Crystallogr 2005 Apr;61(Pt 4):477-80
echinobetaine A  0   Betaine/*analogs & derivatives. J Nat Prod 2005 Feb;68(2);179-82
sulfobetaine  0   Betaine/*analogs & derivatives. J Biomater Appl. 2003 Oct;18(2):123-35
betaine, palmitate drug combination  0   *Palmitic Acids Betaine/analogs & derivatives Drug Combinations. Scand J Gastroenterol 2001 Aug;36(8):811-6
NL 177  0   *Diglycerides Betaine/*analogs & derivatives. Biochem Biophys Res Commun 2001 Aug 24;286(3):464-71
tetradecylbetaine  0   Betaine/*analogs & derivatives. Spectrochim Acta A Mol Biomol Spectrosc 2000 Nov 1;56A(12):2431-7
betaine glucuronate  0   *Glucuronic Acids Betaine/*analogs & derivatives. Arzneimittelforschung 2000 Aug;50(8):722-7
3-oxidopyridinium betaine  0   *Betaine *Pyridinium Compounds. Org Lett 1999 Dec 16;1(12):2017-9
amidopropylhydroxydimethylsulfobetaine  0   Betaine/*analogs & derivatives. Electrophoresis 1999 Sep;20(12):2554-9
ISA 13-1  0   *Diphosphonates Betaine/*analogs & derivatives. Pharm Res 1999 Sep;16(9):1399-406
ammonium sulfobetaine-1  0   Betaine/*analogs & derivatives. J Chromatogr A 1999 Jul 30;850(1-2):161-6
BetL protein, Listeria monocytogenes  0   *Bacterial Proteins *Carrier Proteins Betaine. Appl Environ Microbiol 1999 May;65(5):2078-83
RD6 2198  0   Betaine/*analogs & derivatives. Antiviral Res 1998 May;38(2):141-9
NDSB 256  0   Betaine/*analogs & derivatives. Eur J Biochem 1998 Aug 15;256(1):128-35
C(18)-carboxypropylbetaine  0   Betaine/*analogs & derivatives. J Clin Microbiol 1998 Jul;36(7):1996-2003
NDSB 201  0   Betaine/*analogs & derivatives. Eur J Biochem 1998 Mar 15;252(3):537-41
NDSB 195  0   Betaine/*analogs & derivatives. Eur J Biochem 1998 Mar 15;252(3):537-41
2-(3'-dimethylaminopyrazinio)ethylidene-1,1-bisphosphonic acid betaine  0   *Diphosphonates Betaine/*analogs & derivatives. J Cell Biochem 1998 Feb 1;68(2):186-94
leucine betaine  0   Betaine/*analogs & derivatives Leucine/*analogs & derivatives. Phytochemistry 1996 May;42(2):443-5
hexadecylbetaine  693-33-4   Betaine/*analogs & derivatives. Toxicol Appl Pharmacol 1993 Jun;120(2):224-7
dodecylbetaine  55142-08-0   Betaine/*analogs & derivatives. Toxicol Appl Pharmacol 1993 Jun;120(2):224-7
cocamidopropyl betaine  0   Betaine/*analogs & derivatives.
Pharma Action Surface-Active Agents 		Contact Dermatitis 1992 Apr;26(4):282-3
betaine plasma membrane transport proteins  146313-33-9   *Carrier Proteins Betaine GABA Plasma Membrane Transport Proteins. J Biol Chem 1992;267(1):649
desintegron B  138673-85-5   Betaine/*analogs & derivatives. Mikrobiol Zh 1990;52(3):51
Tego-Betain  52504-27-5   Betaine/*analogs & derivatives. Allerg Immunol (Paris) 1990;22(5):195
selenobetaine methyl ester  102856-52-0   *Organoselenium Compounds Betaine/*analogs & derivatives. Arch Biochem Biophys 1986;247(1):12
selenobetaine  97507-71-6   *Organoselenium Compounds Betaine/*analogs & derivatives. Arch Biochem Biophys 1986;247(1):12
emeriamine  98063-21-9 1-Propanaminium, 2-amino-3-carboxy-N,N,N-trimethyl-, hydroxide, inner salt, (R)  *Carnitine Betaine/*analogs & derivatives Carnitine Acyltransferases/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Hypoglycemic Agents 		Life Sci 1985;37(3):217
C 31G  86903-77-7   *Fatty Acids, Unsaturated Betaine/*analogs & derivatives. Am J Vet Res 1983;44(7):1378
cocobetaine  68411-97-2   Betaine/*analogs & derivatives Allergens Cocos. Contact Dermatitis 1983;9(2):169
laurylamidopropylbetain  0   Betaine/*analogs & derivatives. Acta Trop (Basel) 1982;39(1):79
laurylbetain  683-10-3   Betaine/*analogs & derivatives. Acta Trop (Basel) 1982;39(1):79
betaine, hydrocortisone, lactic acid, urea drug combination  0   *Urea *Betaine *Hydrocortisone *Lactic Acid Drug Combinations. Z Hautkr 1981;56(5):282
betaine, lactic acid, urea drug combination  0   *Urea *Betaine *Lactic Acid Drug Combinations. Z Hautkr 1981;56(5):282
betaine aldehyde  7418-61-3   Betaine/*analogs & derivatives. Biochim Biophys Acta 1980;614(2):274
N-ethyl-6-methyl-2-sulfoquinolinium-betaine  0   Betaine/*analogs & derivatives. Gig Tr Prof Zabol 1980;(10):55
crotonic acid betaine  927-89-9 2-Propen-1-aminium, 3-carboxy-N,N,N-trimethyl-, hydroxide, inner salt  Betaine/*analogs & derivatives. Z Allg Mikrobiol 1979;19(10):753
methylbetaine  13441-31-1 2-carboxy-N,N,N-trimethylethanaminium  Betaine/*analogs & derivatives. J Anim Sci 49(3):764;1979
betaine citrate  17671-50-0 Methanaminium, 1-carboxy-N,N,N-trimethyl-, salt with 2-hydroxy-1,2,3-propanetricarboxylic acid (1:1)  Betaine/*analogs & derivatives. Med Chir Dig 7(5):453;1978
Girard's reagent T  123-46-6 Ethanaminium, 2-hydrazino-N,N,N-trimethyl-2-oxo  Betaine/*analogs & derivatives. J Pharm Sci 65(3):461;1976
hercynine  534-30-5 (1-carboxy-2-imidazol-4-ylethyl)ammonium hydroxide /OD/ histidine-betaine  Betaine/*analogs & derivatives Histidine/*analogs & derivatives.
gamma-butyrobetaine  407-64-7 3-carboxy-N,N,N,-trimethyl-1-propanaminium hydroxide inner salt  *Carnitine Betaine/*analogs & derivatives. BBA 465(3):629;1977; Biochem J 142(3):699;1974; FEBS Lett 102(2):297;1979; Hoppe Seylers Z Physiol Chem 360(2):207;1979; J Biol Chem 248(6):2170;1973
alpha-(1-hydroxycyclohexyl) butyrate betaine  23579-12-6 Methanaminium, 1-carboxy-N,N,N-trimethyl-, salt with alpha-ethyl-1-hydroxycyclohexaneacetic acid (1:1)  Betaine/*analogs & derivatives. Med Chir Dig 1(3):35;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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