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Cysteine Endopeptidases
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Definition
: ENDOPEPTIDASES which have a cysteine involved in the catalytic process. This group of enzymes is inactivated by CYSTEINE PROTEINASE INHIBITORS such as CYSTATINS and SULFHYDRYL REAGENTS.
do not confuse with CYSTEINE PROTEASES
Examples
Bromelains
;
Calpain
;
Caspases
;
Cathepsin B
;
Cathepsin F
;
Cathepsin H
;
Cathepsin K
;
Cathepsin L
;
Cathepsin W
;
Chymopapain
;
Ficain
;
Papain
Substance
CAS Registry & name
Categories
Source
Drugs
*
OTUB1 protein, C elegans
EC 3.4.22.-
*Cysteine Endopeptidases
*Caenorhabditis elegans Proteins.
Nature. 2012 Mar 29;483(7391):618-22
MCA-
1 protein, Plasmodium falciparum
EC 3.4.22.-
*Cysteine Endopeptidases.
PLoS One. 2011;6(8):e23867.
ELS1 protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
Planta 2011 Jan;233(1):63-73
ESD4 protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
Planta 2011 Jan;233(1):63-73
USP26 protein, mouse
EC 3.1.2.15
*Cysteine Endopeptidases.
Asian J Androl. 2009 Jul;11(4):478-83
ATG4D protein, human
EC 3.4.22.-
*Cysteine Endopeptidases.
J Cell Sci. 2009 Jul 15;122(Pt 14);2554-66
otubain 1 protein, human
EC 3.4.22.-
*Cysteine Endopeptidases.
Biochem J 2009 Mar 1;418(2):379-90
OTS2 protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
Plant Cell 2008 Oct;20(10):2894-908
OTS1 protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
Plant Cell 2008 Oct;20(10):2894-908
TbcatB protein, Trypanosoma brucei
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2008 Oct 24;283(43):28934-43
Spr protein, E coli
EC 3.4.22.-
*Cysteine Endopeptidases
*Escherichia coli Proteins.
Biochemistry 2008 Sep 16;47(37):9715-7
cysteine protease 2, Giardia lamblia
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2008 Jun 27;283(26):18024-31
metacaspase-
8, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
J Biol Chem 2008 Jan 11;283(2):774-83
Cwp84 protein, Clostridium difficile
EC 3.4.22.-
*Cysteine Endopeptidases.
J Bacteriol 2007 Oct;189(20):7174-80
echinus protein, Drosophila
EC 3.1.2.15
*Cysteine Endopeptidases
*Drosophila Proteins.
BMC Dev Biol 2007;7:82
Atg4C protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2007 Jun 22;282(25):18573-83
MCA5 protein, Trypanosoma cruzi
EC 3.4.22.-
*Cysteine Endopeptidases
*Protozoan Proteins.
Biocell 2006 Dec;30(3):479-90
MCA3 protein, Trypanosoma cruzi
EC 3.4.22.-
*Cysteine Endopeptidases
*Protozoan Proteins.
Biocell 2006 Dec;30(3):479-90
UfSP2 protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2007 Feb 23;282(8):5256-62
UfSP1 protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2007 Feb 23;282(8):5256-62
Tysnd1 protein, rat
EC 3.4.22.-
*Cysteine Endopeptidases.
EMBO J 2007 Feb 7;26(3):835-45
Ctsla protein, zebrafish
EC 3.4.22.-
*Cathepsins
*Zebrafish Proteins
Cysteine Endopeptidases.
Gene 2007 Jan 15;386(1-2):98-106
NudE-
like protein, rat
EC 3.4.22.-
*Cysteine Endopeptidases.
Proc Natl Acad Sci U S A 2003 Jan 7;100(1):289-94
SUSP4 protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases.
Nat Cell Biol 2006 Dec;8(12):1424-31
Tnfaip3 protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases
*Intracellular Signaling Peptides and Proteins
Nuclear Proteins.
Mc27 protein, Paragonimus westermani
EC 3.4.22.-
*Cysteine Endopeptidases.
Cell Microbiol 2006 Jun;8(6):1034-46
Mc28 protein, Paragonimus westermani
EC 3.4.22.-
*Cysteine Endopeptidases.
Cell Microbiol 2006 Jun;8(6):1034-46
CYLD protein, mouse
EC 3.1.2.15
*Cysteine Endopeptidases.
Cell 2006 May 19;125(4):665-77
sortase E
0
*Bacterial Proteins
*Cysteine Endopeptidases
*Aminoacyltransferases.
sortase D
0
*Bacterial Proteins
*Cysteine Endopeptidases
*Aminoacyltransferases.
sortase C
0
*Bacterial Proteins
*Cysteine Endopeptidases
*Aminoacyltransferases.
sortase B
0
*Bacterial Proteins
*Cysteine Endopeptidases
*Aminoacyltransferases
Peptidoglycan.
UCHL3 protein, human
EC 3.1.2.15
*Cysteine Endopeptidases.
z-
otu protein, zebrafish
EC 3.4.22.-
*Cysteine Endopeptidases
*Zebrafish Proteins.
Biochim Biophys Acta 2005 Dec 30;1732(1-3):1-7
fastuosain, Bromelia fastuosa
EC 3.4.22.-
*Cysteine Endopeptidases.
Protein Pept Lett 2006 Jan;13(1):83-9
Fas2 antigen, Fasciola hepatica
EC 3.4.22.-
*Antigens, Helminth
*Cysteine Endopeptidases.
J Helminthol 2005 Sep;79(3):235-40
otubain 1 protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases
Neoplasm Proteins.
FEBS Lett 2006 Jan 9;580(1):179-83
ATG4B protein, human
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2005 Dec 2;280(48):40058-65
caricain II
EC 3.4.22.-
*Cysteine Endopeptidases
*Peptide Fragments.
Protein J 2005 May;24(4):243-51
Nep1 protein, S pombe
EC 3.4.22.-
*Cysteine Endopeptidases
*Schizosaccharomyces pombe Proteins.
Biochem J 2005 Jul 15;389(Pt 2):307-14
USP26 protein, human
EC 3.1.2.15
*Cysteine Endopeptidases.
Eur J Hum Genet 2005 Mar;13(3):336-40
SENP2 protein, human
EC 3.4.22.-
*Cysteine Endopeptidases.
staphopain A protein, Staphylococcus aureus
EC 3.4.22.-
*Cysteine Endopeptidases.
Biochem J 2005 Jan 1;385(Pt 1):181-7
MCP2b protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
J Biol Chem 2005 Apr 15;280(15):14691-9
MCP1b protein, Arabidopsis
EC 3.4.22.-
*Cysteine Endopeptidases
*Arabidopsis Proteins.
J Biol Chem 2005 Apr 15;280(15):14691-9
SENP3 protein, human
EC 3.4.22.-
*Cysteine Endopeptidases.
Mol Cell Biol 2005 Mar;25(6):2273-87
YDR533c protein, S cerevisiae
EC 3.4.22.-
*Heat-Shock Proteins
*Saccharomyces cerevisiae Proteins
Cysteine Endopeptidases.
Structure (Camb) 2004 May;12(5):839-47
Protollin
0
*Cysteine Endopeptidases
*Lipopolysaccharides
Drug Combinations.
Vaccine 2004 Sep 9;22(27-28):3691-7
Psmb10 protein, rat
EC 3.4.99.46
*Cysteine Endopeptidases.
Psmb10 protein, mouse
EC 3.4.99.46
*Cysteine Endopeptidases.
CASP2 protein, human
EC 3.4.22.-
*Cysteine Endopeptidases
*Caspase 2
Apoptosis.
Casp2 protein, rat
EC 3.4.22.-
*Cysteine Endopeptidases
Apoptosis.
alpha4 subunit, proteasome 20S, human
EC 3.4.25.1
*Cysteine Endopeptidases
Protein Subunits.
FEBS Lett 2004 Jul 2;569(1-3):211-6
HMCN1 protein, human
0
*Immunoglobulins
Cysteine Endopeptidases.
N Engl J Med 2004 Jul 22;351(4):346-53
ervatamin C, Ervatamia coronaria
EC 3.4.22.-
*Cysteine Endopeptidases.
Biochemistry 2004 Feb 17;43(6):1532-40
hieronymain I, Bromelia hieronymi
EC 3.4.22.-
*Cysteine Endopeptidases.
J Protein Chem 2003 Feb;22(2);127-34
Atg4bl protein, mouse
EC 3.4.22.-
*Cysteine Endopeptidases.
J Biol Chem 2003 Dec 19;278(51):51841-50
morrenain b I, Morrenia brachystephana
EC 3.4.22.-
*Cysteine Endopeptidases.
J Protein Chem 2003 Jan;22(1):15-22
3C-
like protease, SARS coronavirus
EC 3.4.22.-
*Cysteine Endopeptidases
*Viral Proteins.
Proc Natl Acad Sci U S A 2003 Nov 11;100(23):13190-5
Pup1 protein, S cerevisiae
EC 3.4.25.1
*Cysteine Endopeptidases.
Mol Microbiol 2003 Sep;49(5):1309-32
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