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Dipeptidyl-Peptidases and Tripeptidyl-Peptidases

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Definition: A subclass of exopeptidases that includes enzymes which cleave either two or three AMINO ACIDS from the end of a peptide chain.     
Examples Cathepsin C; Dipeptidyl Peptidase 4; Peptidyl-Dipeptidase A 		Other names Dipeptidyl Peptidases; Tripeptidyl-Peptidases and Dipeptidyl-Peptidases; Tripeptidyl Peptidases; Dipeptidyl Peptidases and Tripeptidyl Peptidases; Tripeptidyl-Peptidases; Dipeptidylpeptide Hydrolases
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
DPP6 protein, mouse  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Acta Histochem. 2011 Oct;113(6):636-9
DPP6 protein, rat  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Channels (Austin) 2009 Nov;3(6):448-61
DPP3 protein, human  EC 3.4.14.4   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases.
Dpp9 protein, rat  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. J Histochem Cytochem 2008 Feb;56(2):147-55
Dpp8 protein, rat  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. J Histochem Cytochem 2008 Feb;56(2):147-55
DPP10 protein, rat  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Mol Cell Neurosci. 2007 Aug;35(4):604-24
talabostat  0   *Boronic Acids *Dipeptides Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & inhibitors. Drug News Perspect 2006 Jun;19(5):299
DPP6 protein, human  EC 3.4.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases *Nerve Tissue Proteins *Potassium Channels. J Physiol. 2005 Jun 15;565(Pt 3):751-6
DPP10 protein, human  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Biochem J 2003 Jul 1;373(Pt 1):179-89
DPP9 protein, human  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Gene 2002 Oct 16;299(1-2):185-93
dipeptidylpeptidase V, Asperigillus fumigatus  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Blood 2002 Dec 15;100(13):4521-8
x-prolyl dipeptidyl peptidase, C  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases Bacterial Proteins. Infect Immun 2001 Sep;69(9):5494-501
DP IV-related protease, human  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Adv Exp Med Biol 2000;477:103-9
PtpA protein, Porphyromonas gingivalis  EC 3.4.14.-   *Bacterial Proteins *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases *Serine Endopeptidases. J Biol Chem 1999 Apr 2;274(14):9246-52
bis(4-acetamidophenyl) 1-prolylpyrrolidine-2-phosphonate  0   *Phosphonic Acids Proline/*analogs & derivatives Dipeptidyl-Peptidases and Tripeptidyl-Peptidases/antagonists & inhibitors. J Med Chem 1999 Mar 25;42(6):1041-52
DAP BI protein, Pseudomonas  EC 3.4.14.-   *Bacterial Proteins *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. J Bacteriol 1996 Mar;178(5):1283-8
dipeptidyl peptidase III  EC 3.4.14.4   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases.
dipeptidyl peptidase II  EC 3.4.14.2   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases.
PepX dipeptidyl aminopeptidase  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Proteins 1995 Oct;23(2):278-81
tripeptidyl-peptidase 1  EC 3.4.14.9   *Aminopeptidases *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases *Serine Proteases Neuronal Ceroid-Lipofuscinoses Biological Markers. Arch Biochem Biophys 1993 Nov 1;306(2):354-9
STE13 protein, S cerevisiae  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases *Saccharomyces cerevisiae Proteins. Mol Cell Biol 1989;9(10):4507
glycylprolyl dipeptidase  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Fems Microbiol Lett 1989;48(1):93
dipeptidyl aminopeptidase B  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. J Cell Biol 1989;108(4):1363
tripeptidyl-peptidase 2  EC 3.4.14.10   *Aminopeptidases *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases *Serine Endopeptidases. J Biol Chem 1986;261(5):2409
met-enkephalin dipeptidyl aminopeptidase  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Biochem Biophys Res Commun 1982;105(2):470
tripeptide aminopeptidase  EC 3.4.11.4   *Aminopeptidases *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. J Biochem (Tokyo) 1980;87(5):1403
glycylproline 4-nitroanilidase  EC 3.4.14.-   *Dipeptidyl-Peptidases and Tripeptidyl-Peptidases. Clin Chim Acta 74(2):177;1977; Clin Chim Acta 81:215;1977; Jpn Heart J 20(4):469;1979; Ryumachi 18(4):231;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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