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Pentoxifylline

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Definition: A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.     
Pharmacological Action Free Radical Scavengers; Phosphodiesterase Inhibitors; Platelet Aggregation Inhibitors; Radiation-Protective Agents; Vasodilator Agents 		Other names BL191; BL 191; Trental; Torental; Pentoxil; Oxpentifylline; BL-191; AgapurinDrugs* : PENTOXIL; TRENTAL; PENTOXIFYLLINE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pentoxifylline-tocopherol-clodronate  0   *Clodronic Acid *Pentoxifylline *Tocopherols Drug Combinations Osteoradionecrosis/drug therapy Bone Density Conservation Agents. Int J Radiat Oncol Biol Phys. 2011 Jul 1;80(3);832-9
8-oxolisofylline  0   Pentoxifylline/*analogs & derivatives. Biochem Biophys Res Commun 2001 Nov 16;288(5):1212-7
8-oxopentoxifylline  0   Pentoxifylline/*analogs & derivatives. Biochem Biophys Res Commun 2001 Nov 16;288(5):1212-7
lisofylline 4,5-diol  0   Pentoxifylline/*analogs & derivatives. J Pharm Sci 1998 Mar;87(3):390-3
1-(5-hydroxy-5-methylhexyl)-3-methylxanthine  107767-55-5   Pentoxifylline/*analogs & derivatives.
Pharma Action Bronchodilator Agents 		Pharmatherapeutica 1989;5(6):407
torbafylline  105102-21-4   Pentoxifylline/*analogs & derivatives. Prog Clin Biol Res 1989;301:223
pentoxifylline-alpha-methoxy-alpha-(trifluoromethyl)phenylacetate ester  130007-50-0   Pentoxifylline/*analogs & derivatives. Xenobiotica 1985;15(12):1001
1-(4'-carboxybutyl)-3,7-dimethylxanthine  38975-44-9   Pentoxifylline/*analogs & derivatives. J Chromatogr 1985;344:397
1-(3'-carboxypropyl)-3,7-dimethylxanthine  6493-07-8   Pentoxifylline/*analogs & derivatives. J Chromatogr 1985;344:397
lisofylline  6493-06-7 1H-purine-2,6-dione, 3,7-dihydro-1-(5-hydroxyhexyl)-3,7-dimethyl  Pentoxifylline/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic ; Anti-Inflammatory Agents, Non-Steroidal ; Immunosuppressive Agents ; Radiation-Sensitizing Agents 		J Chromatogr 1980;181(3-4):355

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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