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Transglutaminases

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Definition: Transglutaminases catalyze cross-linking of proteins at a GLUTAMINE in one chain with LYSINE in another chain. They include keratinocyte transglutaminase (TGM1 or TGK), tissue transglutaminase (TGM2 or TGC), plasma transglutaminase involved with coagulation (FACTOR XIII and FACTOR XIIIa), hair follicle transglutaminase, and prostate transglutaminase. Although structures differ, they share an active site (YGQCW) and strict CALCIUM dependence.  distinguish X refs GLUTAMINYL-PEPTIDE GAMMA-GLUTAMYLTRANSFERASES and TRANSGLUTAMINASES from GAMMA-GLUTAMYL TRANSPEPTIDASE which is involved with glutathione metabolism; PLASMA TRANSGLUTAMINASE see FACTOR XIIIA is also available   
Examples Factor XIIIa 		Other names Protein-Glutamine gamma-Glutamyltransferases; Glutaminyl-Peptide Gamma-Glutamyltransferases; gamma-Glutamyltransferases, Protein-Glutamine; Protein Glutamine gamma Glutamyltransferases; Glutaminyl Peptide Gamma Glutamyltransferases; Gamma-Glutamyltransferases, Glutaminyl-Peptide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
transglutaminase 6, human  EC 2.3.2.13   *Transglutaminases. Ann Neurol 2008 Sep;64(3):332-43
CG7356 protein, Drosophila  EC 2.3.2.13   *Transglutaminases *Drosophila Proteins. Dev Dyn 2008 Aug;237(8):2090-9
Ghalpha protein, rat  0   *Transglutaminases *GTP-Binding Proteins Intracellular Signaling Peptides and Proteins. Science 1994 Jun 10;264(5165):1593-6
tissue transglutaminase 2, human  EC 2.3.2.13   *Transglutaminases. Biochem Biophys Res Commun 2006 Jan 13;339(2):726-30
Tgm3 protein, mouse  EC 2.3.2.-   *Transglutaminases.
TGM3 protein, human  EC 2.3.2.13   *Transglutaminases.
transglutaminase 5  EC 2.3.2.-   *Transglutaminases.
transglutaminase 4  EC 2.3.2.-   *Transglutaminases.
1,3-dimethyl-4,5-diphenyl-22(oxopropyl)thioimidazolium trifluoromethylsulfonate  0   *Imidazoles Transglutaminases/antagonists & inhibitors. Biophys J 1999 Nov;77(5):2827-36
transglutaminase NII  EC 2.3.2.-   *Transglutaminases. Exp Mol Med 1998 Dec 31;30(4):177-85
transglutaminase NI  EC 2.3.2.-   *Transglutaminases. Exp Mol Med 1998 Dec 31;30(4):177-85
tridegin  0   *Salivary Proteins and Peptides Leeches Transglutaminases/antagonists & inhibitors. Biochem J 1997 Jun 15;324(Pt 3):797-805
transglutaminase 1  EC 2.3.2.13   *Transglutaminases. Arch Dermatol Res 1997 Jan;289(2):116-9
RS 48373  0   *Isoxazoles Transglutaminases/antagonists & inhibitors. Neurochem Int 1996 Aug;29(2):129-34
transglutaminase 2  EC 2.3.2.-   *Transglutaminases *GTP-Binding Proteins. Circulation 1996 Aug 15;94(4):718-26
1,3-dimethyl-2-((2-oxopropyl)thio)imidazolium  135273-74-4   *Imidazoles Transglutaminases/antagonists & inhibitors. Biochemistry 1994 Aug 23;33(33):10109-19
1,3,4,5-tetramethyl-2-((2-oxopropyl)thio)imidazolium  134218-50-1   *Imidazoles Transglutaminases/antagonists & inhibitors. Biochemistry 1994 Aug 23;33(33):10109-19
XPC protein, human  156533-34-5   *DNA-Binding Proteins DNA Repair Transglutaminases Xeroderma Pigmentosum. EMBO J 1994 Apr 15;13(8):1831-43
RAD4 protein, S pombe  0   *DNA-Binding Proteins *Transglutaminases *Schizosaccharomyces pombe Proteins. Cell 1993 Jul 30;74(2):383-93
dermonecrotic toxin, Bordetella  0   *Virulence Factors, Bordetella *Transglutaminases Bordetella. Microb Pathog 1989;6(5):361
1-(5-aminopentyl)-3-phenylthiourea  99223-34-4 Thiourea, N-(5-aminopentyl)-N'-phenyl  Phenylthiourea/*analogs & derivatives Transglutaminases/antagonists & inhibitors. Biochim Biophys Acta 1988;972(2):120
1-(2-aminoethyl)-3-phenylthiourea  31090-77-4   Phenylthiourea/*analogs & derivatives Transglutaminases/antagonists & inhibitors. Biochem Biophys Acta 1988;972(2):120
monodansylthiacadaverine  52664-04-7   Cadaverine/*analogs & derivatives Transglutaminases/antagonists & inhibitors. Diabetes Res 1987;5(1):29
monodansylcadaverine  10121-91-2 N-(5-aminopentyl)-5-dimethylamino-1-naphthalenesulfonamide  Cadaverine/*analogs & derivatives Transglutaminases/antagonists & inhibitors.
Pharma Action Antineoplastic Agents ; Enzyme Inhibitors ; Fluorescent Dyes ; Immunosuppressive Agents 		Biochem 17(11):2163;1978; J Biol Chem 1980;255(4):1239; J Histochem Cytochem 26(5):340;1978; J Natl Can Inst 52(3):733;1974; W1 PR6672 Vol 1:67;1975

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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