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Pyruvate Dehydrogenase Complex

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Definition: A multienzyme complex responsible for the formation of ACETYL COENZYME A from pyruvate. The enzyme components are PYRUVATE DEHYDROGENASE (LIPOAMIDE); dihydrolipoamide acetyltransferase; and LIPOAMIDE DEHYDROGENASE. Pyruvate dehydrogenase complex is subject to three types of control: inhibited by acetyl-CoA and NADH; influenced by the energy state of the cell; and inhibited when a specific serine residue in the pyruvate decarboxylase is phosphorylated by ATP. PYRUVATE DEHYDROGENASE (LIPOAMIDE)-PHOSPHATASE catalyzes reactivation of the complex. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed)     
Examples Dihydrolipoamide Dehydrogenase; Dihydrolipoyllysine-Residue Acetyltransferase; Pyruvate Dehydrogenase (Lipoamide) 		Other names Dehydrogenase Complex, Pyruvate; Complex, Pyruvate Dehydrogenase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
pyruvate dehydrogenase complex component X, Bos taurus  0   *Pyruvate Dehydrogenase Complex.
PDX1 protein, S cerevisiae  0   *Pyruvate Dehydrogenase Complex *Saccharomyces cerevisiae Proteins.
pyruvate dehydrogenase multienzyme complex E1  0   *Pyruvate Dehydrogenase Complex. Biochemistry 2002 Apr 23;41(16):5213-21
thiamine thiazolone  490-82-4   Thiamine/*analogs & derivatives Pyruvate Dehydrogenase Complex/antagonists & inhibitors. Biochem Pharmacol 1988;37(22):4375
PDHX protein, human  0   *Pyruvate Dehydrogenase Complex. Eur J Biochem 1985;149(3):641
thiamine thiothiazolone pyrophosphate  59733-98-1 Diphosphoric acid, mono(2-(3-((4-amino-2-methyl-5-pyrimidinyl)methyl)-2,3-dihydro-4-methyl-2-thioxo-5-thiazolyl)ethyl) ester  Thiamine Pyrophosphate/*analogs & derivatives Pyruvate Dehydrogenase Complex/antagonists & inhibitors. Biochem J 1981;195(3):715
pyruvate dehydrogenase activator  0   *Pyruvate Dehydrogenase Complex. J Biol Chem 1981;256(6):2894
pyruvate dehydrogenase complex inactivase  EC 3.4.-   *Peptide Hydrolases Pyruvate Dehydrogenase Complex/antagonists & inhibitors. Biochem J 169(2):321;1978; Eur J Biochem 95(3):569;1979
bromopyruvate  1113-59-3   *Pyruvates Pyruvate Dehydrogenase Complex/antagonists & inhibitors.
Pharma Action Affinity Labels ; Enzyme Inhibitors 		Biochem Biophys Res Commun 84(3):589;1978; Biochemistry 17(19):4024;1978; Ital J Biochem 27(4):283;1978; J Biochem (Tokyo) 1979;86(5):1251; J Neurochem 30:949;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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