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Strychnine

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Definition: An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison.     
Pharmacological Action Convulsants; Glycine Agents; Poisons 		Other names Nitrate, Strychnine; Strychnine Nitrate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
coracurine V  0   Strychnine/*analogs & derivatives Ligands. J Med Chem 2004 Jul 1;47(14):3561-71
strychnohexamine  0   *Carbazoles Strychnine/*analogs & derivatives. Phytochemistry 2003 Feb;62(4):623-9
sungucine  73020-53-8   *Strychnine. Planta Med 2002 Jul;68(7):591-5
icajine  30864-63-2   Strychnine/*analogs & derivatives. Planta Med 2001 Aug;67(6):523-7
3-epi-myrtoidine  0   Strychnine/*analogs & derivatives. Phytochemistry 2001 Apr;56(8):863-7
11-demethoxy-3-epi-myrtoidine  0   Strychnine/*analogs & derivatives. Phytochemistry 2001 Apr;56(8):863-7
11-demethoxy-12-hydroxy-3-epi-myrtoidine  0   Strychnine/*analogs & derivatives. Phytochemistry 2001 Apr;56(8):863-7
strychnogucine B  0   Strychnine/*analogs & derivatives. J Nat Prod 2001 Jan;64(1):12-6
strychnogucine A  0   Strychnine/*analogs & derivatives. J Nat Prod 2001 Jan;64(1):12-6
N-chloromethylbrucine  0   Strychnine/*analogs & derivatives. Mol Pharmacol 1999 Apr;55(4):778-86
isobrucine  129724-78-3   Strychnine/*analogs & derivatives Drugs, Chinese Herbal. Chung Kuo Chung Yao Tsa Chih 1993 Dec;18(12):739-40
brucine  357-57-3 Strychnidin-10-one, 2,3-dimethoxy  Strychnine/*analogs & derivatives.
Pharma Action Adjuvants, Immunologic ; Analgesics ; Indicators and Reagents
strychnine N-oxide  7248-28-4   *Cyclic N-Oxides Strychnine/*analogs & derivatives. Planta Med 1993 Aug;59(4):347-50
brucine N-oxide  17301-81-4   *Cyclic N-Oxides Strychnine/*analogs & derivatives. Planta Med 1993 Aug;59(4):347-50
22-hydroxystrychnine  134250-41-2 Strychnidin-10-one, 22-hydroxy  Strychnine/*analogs & derivatives. Xenobiotica 1991;21(3):395
11-methoxymacusine A  87340-28-1   Strychnine/*analogs & derivatives. J Nat Prod 1983;46(4):572
Pasuma (injection)  0   *Testosterone *Vitamin E Drug Combinations Strychnine/*analogs & derivatives Yohimbine/*analogs & derivatives. S Afr Med J 53(18):693;1978
N-methylstrychnine  47466-17-1   Strychnine/*analogs & derivatives. Biophys J 23(2):285;1978
Wenckebach's Dragee  78920-40-8 Strychnidin-10-one, mononitrate, mixt. with Digitalis glycosides and (8alpha,9R)-6'-methoxycinchonan-9-ol sulfate (2:1) (salt)  *Digitalis Glycosides *Quinine *Strychnine Drug Combinations. Sud Med Ekspert 16(2):40;1973
afrodex  8054-03-3 Afrodex  *Methyltestosterone *Strychnine *Yohimbine Drug Combinations. Curr Therap Res 16(1):96;1974
Pasuma (tablet)  0   *Caffeine *Ephedrine *Methyltestosterone *Vitamin E *Yohimbine Drug Combinations Strychnine/*analogs & derivatives. S Afr Med J 53(18):693;1978

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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