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Receptors, sigma

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Definition: A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues.  opioid receptors; DF: RECEPT SIGMA    Other names sigma Receptors; Receptors, sigma Opioid; Receptors, Opioid, sigma; Opioid Receptors, sigma; sigma Opioid Receptors; Receptor, sigma; sigma Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-((1-adamantyl(methyl)amino)methyl)-1-phenylcyclopropanecarboxylic acid  0   *Cyclopropanes Adamantane/*analogs & derivatives Receptors, sigma/agonists. J Alzheimers Dis 2011;24(3):569-86
4-(4-ethyl-piperazin-1-yl)-1-(2,3,4-trihydroxyphenyl)butan-1-one  0   *Piperazines Gallic Acid/*analogs & derivatives Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
dimethyl-carbamic acid 2,3-bis-dimethylcarbamoyloxy-6-(4-ethylpiperazine-1-carbonyl)phenyl ester  0   *Carbamates *Piperazines Cholinesterase Inhibitors Receptors, sigma/antagonists & inhibitors. Med Chem 2010 May 1;6(3):123-40
6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo(d)oxazol-2(3H)-one  0   *Benzoxazoles *Piperazines Receptors, sigma/antagonists & inhibitors. Biol Psychiatry 2011 Feb 1;69(3):208-17
4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butyl 4-phenylbutyrate  0   *Phenylbutyrates Haloperidol/*analogs & derivatives Receptors, sigma/antagonists & inhibitors. Eur J Med Chem 2011 Jan;46(1):433-8
N,N-dibutyl-3-(4-nitrophenyl)propylamine  0   *Propylamines Ligands Receptors, sigma. Bioorg Med Chem 2010 Jun 15;18(12):4397-404
N-((benzofuran-2-yl)methyl)-N'-(4'-methoxybenzyl)piperazine  0   *Benzofurans *Piperazines Carbon Radioisotopes Ligands Receptors, sigma. J Med Chem 2010 Aug 26;53(16):6228-39
F281 compound  0   *Carbazoles *Piperazines Receptors, sigma/agonists. Cell Calcium 2009 Apr;45(4):340-5
2-(3,4-dichlorophenyl)-N-ethyl-N-(2-piperidin-1-ylethyl)ethanamine  0   *Piperidines Receptors, sigma/agonists. Eur Neuropsychopharmacol 2007 Nov;17(11):708-16
1-(3-phenylpropyl)piperidine  0   *Piperidines Receptors, sigma/agonists. Eur Neuropsychopharmacol 2007 Nov;17(11):708-16
1-(2-phenethyl)-4-(2-pyridyl)piperazine  0   *Piperazines *Pyridines Receptors, sigma/antagonists & inhibitors. Pharmacol Biochem Behav 2007 Jan;86(1):86-91
methyl 2-((4-hydroxy-4-phenylpiperidin-1-yl)methyl)-1-(4-methylphenyl)cyclopropanecarboxylate  0   *Cyclopropanes *Piperidines Ligands Receptors, sigma/agonists. J Med Chem 2007 Mar 8;50(5):951-61
PB28 compound  0   *Piperazines Receptors, sigma/antagonists & inhibitors Receptors, sigma/agonists. J Med Chem 1996 Jan 5;39(1):176-82
m-(p-chlorobenzyloxy)-N-cyclopropylmethyl-N-methylbenzylamine  0   *Benzylamines *Cyclopropanes Ligands Receptors, sigma. Nippon Yakurigaku Zasshi 1999 Oct;114 Suppl 1:204P-208P
N-(N-benzylpiperidin-4-yl)-2-iodobenzamide  0   *Benzamides *Piperidines Iodine Radioisotopes Receptors, sigma. Nucl Med Biol 1998 Apr;25(3):189-94
N-(N-benzylpiperidin-4-yl)-2-fluorobenzamide  0   *Benzamides *Piperidines Receptors, sigma. Nucl Med Biol 1997 Oct;24(7):685-91
sigma-2 receptor  0   *Receptors, sigma. Nucl Med Biol 1997 Feb;24(2):127-34
sigma-1 receptor  0   *Receptors, sigma. Nucl Med Biol 1997 Feb;24(2):127-34
SA 4503  0   *Piperazines Carbon Radioisotopes Receptors, sigma/agonists.
Pharma Action Nootropic Agents 		J Pharmacol Exp Ther 1996 Oct;279(1):106-13
sigma1-binding protein, rat  0   *Receptors, sigma. Proc Natl Acad Sci U S A 1996 Jul 23;93(15):8072-7
BD 1047  138356-20-4   *Ethylenediamines Ligands Receptors, sigma/antagonists & inhibitors. Eur J Pharmacol 1995 Jul 14;280(3):301-10
L 687384  95417-67-7   *Piperidines Receptors, sigma. Neurosci Lett 1994 Jun 20;174(2):181-4
SR 31747  132173-07-0   *Cyclohexanes Receptors, sigma. J Neuroimmunol 1994 Jul;52(2):183-92
N-(N-benzylpiperidin-4-yl)-4-iodobenzamide  155798-12-2   *Benzamides *Piperidines Iodine Radioisotopes Receptors, sigma/agonists. J Med Chem 1994 Jun 10;37(12):1737-9
BD 1008  138356-08-8   *Ethylamines *Pyrrolidines Receptors, sigma. J Med Chem 1994 Jan 21;37(2):314-21
N-(1-phenylpropionyl)-4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine  152565-99-6   *Dihydropyridines *Propiophenones Receptors, sigma. J Med Chem 1993 Nov 26;36(24):3923-8
N-(1-phenylpropionyl)-4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridine  152565-98-5   *Dihydropyridines *Propiophenones Receptors, sigma. J Med Chem 1993 Nov 26;36(24):3923-8
6-(6-(4-hydroxypiperidinyl)hexyloxy)-3-methylflavone hydrochloride  139652-86-1 4H-1-Benzopyran-4-one, 6-((6-(4-hydroxy-1-piperidinyl)hexyl)oxy)-3-methyl-2-phenyl-, hydrochloride  *Flavonoids *Piperidines Receptors, sigma. J Pharmacol Exp Ther 1993 May;265(2):866-75
3-(hexahydroazepin-1-yl)-1-(3-chloro-4-cyclohexylphenyl)-1-propene hydrochloride  139592-99-7   *Azepines Receptors, sigma. Eur J Pharmacol 1993 Feb 16;231(3):465-7

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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