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Receptors, Bombesin

More information in Books or onNLM PubMed
Definition: Cell surface proteins that bind bombesin or closely related peptides with high affinity and trigger intracellular changes influencing the behavior of cells. Gastrin- releasing peptide (GRP); GRP 18-27 (neuromedin C), and neuromedin B are endogenous ligands of bombesin receptors in mammals.  DF: RECEPT BOMBESIN    Other names Receptors, Neuromedin B; Receptors, Gastrin-Releasing Peptide; Neuromedin B Receptors; Gastrin-Releasing Peptide Receptors; Bombesin Receptors; Receptors, Gastrin Releasing Peptide; Receptor, Neuromedin B; Receptor, Gastrin-Releasing Peptide; Receptor, Bombesin; Peptide Receptors, Gastrin-Releasing; Peptide Receptor, Gastrin-Releasing; Gastrin Releasing Peptide Receptors; Gastrin Releasing Peptide Receptor; B Receptors, Neuromedin; B Receptor, Neuromedin; Neuromedin B Receptor; Gastrin-Releasing Peptide Receptor; Bombesin Receptor
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
1,1,1-trifluoro-2-(4-(1H-pyrazol-1-yl)phenyl)-3-(4-((1-(trifluoromethyl)cyclopropyl)methyl)-1H-imidazol-2-yl)propan-2-ol  0   *Imidazoles *Pyrazoles Receptors, Bombesin/agonists. J Pharmacol Exp Ther 2011 Feb;336(2):356-64
7-benzyl-5-(piperidin-1-yl)-6,7,8,9-tetrahydro-3H-pyrazolo(3,4-c)(2,7)-naphthyridin-1-ylamine  0   *Naphthyridines *Pyrazoles Receptors, Bombesin/agonists. Bioorg Med Chem Lett 2010 May 1;20(9):2785-9
2-(2-(4-(pyridin-2-yl)phenyl)ethyl)-5-(2,2-dimethylbutyl)-1H-imidazole  0   *Imidazoles Receptors, Bombesin/agonists. Bioorg Med Chem Lett 2010 Apr 1;20(7):2074-7
acetyl-phenylalanyl-tryptophyl-alanyl-histidyl(TauBzl)-Nip-glycyl-argininamide  0   *Oligopeptides Receptors, Bombesin/agonists. J Pharmacol Exp Ther 2010 Apr;333(1):51-9
bombesin(6-14), Tyr(6)-Apa(11)-Phe(13)-Nle(14)  0   *Peptide Fragments Bombesin/*analogs & derivatives Receptors, Bombesin/agonists. J Pharmacol Exp Ther 2010 Apr;333(1):51-9
PD 168368  0   *Indoles *Pyridines Receptors, Bombesin/antagonists & inhibitors. J Biol Chem 2001 Jan 5;276(1):495-504
PD 165929  0   *Indoles Receptors, Bombesin. Bioorg Med Chem Lett 1998 Sep 22;8(18):2589-94
PD 176252  0   *Indoles Receptors, Bombesin. Bioorg Med Chem Lett 1998 Sep 22;8(18):2589-94
bombesin receptor subtype 4  0   *Receptors, Bombesin. J Biol Chem 1997 Jul 11;272(28):17405-9
bombesin receptor subtype 3  0   *Receptors, Bombesin. J Biol Chem 1997 Jul 11;272(28):17405-9
BW 1023U90  0   *Oligopeptides Receptors, Bombesin/antagonists & inhibitors. Peptides 1996;17(8):1337-43

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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