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Receptors, Adrenergic, alpha-1

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Definition: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.      Other names alpha-1 Adrenergic Receptors; Receptors, alpha-1 Adrenergic; Adrenergic alpha-1 Receptors; alpha-1D Receptors, Adrenergic; alpha-1B Receptors, Adrenergic; alpha-1A Receptors, Adrenergic; alpha-1 Receptors, Adrenergic; alpha-1 Adrenergic Receptor; alpha 1D Adrenergic Receptor; alpha 1C Adrenergic Receptor; alpha 1B Adrenergic Receptor; alpha 1A Adrenergic Receptor; alpha 1 Adrenergic Receptors; Receptors, alpha 1 Adrenergic; Receptors, Adrenergic alpha-1D; Receptors, Adrenergic alpha-1B; Receptors, Adrenergic alpha-1A; Receptors, Adrenergic alpha-1; Receptor, alpha-1D Adrenergic; Receptor, alpha-1C Adrenergic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-((11-(4-methylpiperazin-1-yl)-10,11-dihydrodibenzo(b,f)thiepin-2-yl)methyl)isobutyramide  0   *Dibenzothiepins Ligands Receptors, Adrenergic, alpha-1. J Med Chem 2010 Oct 14;53(19):7021-34
AdTx1 peptide, Dendroaspis angusticep  0   *Peptides *Elapid Venoms Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Br J Pharmacol 2010 Jan 1;159(2):316-25
Adra1d protein, rat  0   *Receptors, Adrenergic, alpha-1.
Adra1d protein, mouse  0   *Receptors, Adrenergic, alpha-1.
ADRA1D protein, human  0   *Receptors, Adrenergic, alpha-1.
Adra1b protein, rat  0   *Receptors, Adrenergic, alpha-1.
Adra1b protein, mouse  0   *Receptors, Adrenergic, alpha-1.
ADRA1B protein, human  0   *Receptors, Adrenergic, alpha-1.
Adra1a protein, rat  0   *Receptors, Adrenergic, alpha-1.
Adra1a protein, mouse  0   *Receptors, Adrenergic, alpha-1.
ADRA1A protein, human  0   *Receptors, Adrenergic, alpha-1.
2-(3-(4-(2-isopropoxyphenyl)piperazin-1-yl)propyl)-3a,4,7,7a-tetrahydroisoindole-1,3-dione  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Pharmacol 2009 Apr 1;607(1-3):213-9
2-(4-methylphenyll)-2,3-dihydro-N-(2-hydroxy-3-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)propyl)-1,3-dioxo-1H-isoindole-5-carboxamide  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
2-(3-fluorophenyl)-2,3-dihydro-N-(2-hydroxy-3-(4-(2-(1-methylethoxy)phenyl)-1-piperazinyl)propyl)-1,3-dioxo-1H-isoindole-5-carboxamide  0   *Phthalimides *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
N-(2-methyl-(4-indolyl-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexane carboxamide  0   *Aminopyridines *Piperazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors Receptor, Serotonin, 5-HT1A/antagonists & inhibitors. Auton Autacoid Pharmacol 2005 Oct;25(4):185-9
8-(2-(4-(2,4,5-trifluorophenyl)piperazin-1-yl)-1-methylethyl)-8-azaspiro(4.5)decane-7,9-dione  0   *Piperazines *Spiro Compounds Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):3076-9
8-(2-(4-(2,4,5-trifluorophenyl)piperazin-1-yl)ethyl)-8-azaspiro(4.5)decane-7,9-dione  0   *Piperazines *Spiro Compounds Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2005 Apr 21;48(8):3076-9
8-(2-(4-(2,5-dichlorophenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)dec-9,10-en-7-one  0   *Imides *Spiro Compounds Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1900-18
8-((4-(2,5-dichlorophenyl)-1-piperazinyl)ethyl)-8-azaspiro(4,5)decane-7,9-dione  0   *Imides *Spiro Compounds Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2004 Apr 8;47(8):1900-18
4-amino-5-(4-fluorophenyl)-6,7-dimethoxy-2-(4-(morpholinocarbonyl)--perhydro-1,4-diazepin-1-yl)quinoline  0   *Azepines *Quinolines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Drug Metab Dispos 2004 Feb;32(2):197-204
dabuzalgron  0   *Imidazoles *Sulfonamides Receptors, Adrenergic, alpha-1/agonists. BJU Int 2004 Jan;93(1):162-70
2-(2-(n-4-o-methoxyphenyl-N-1-piperazinyl)ethyl)-1-tetralone  0   *Piperazines *Tetralones Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Vascul Pharmacol 2003 Feb;40(2):97-108
4-(2-phenoxyethylaminomethyl)-2,2-diphenyl(1,3)dioxolane  0   *Dioxolanes Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2003 Apr 10;46(8):1504-11
4-(2-(2-methoxyphenoxy)ethylaminomethyl)-2,2-diphenyl(1,3)dioxolane  0   *Dioxolanes Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2003 Apr 10;46(8):1504-11
2-(4-(4-(2-methoxyphenyl)piperazinyl)butyl)amino-4-cyclohexylaminoquinazoline  0   *Piperazines *Quinazolines Receptors, Adrenergic, alpha-1. Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
4-(3-(4-(2-methoxyphenyl)piperazinyl)propyl)aminoquinazolin-2-carboxamide  0   *Piperazines *Quinazolines Receptors, Adrenergic, alpha-1. Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
ethyl 4-(3-(4-(2-methoxyphenyl)piperazinyl)propyl)aminoquinazolin-2-carboxylate  0   *Piperazines *Quinazolines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
6-(1-indolyl)-2-((4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyridazin-3(2H)-one  0   *Piperazines *Pyridazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2002 Aug 15;45(17):3603-11
6-(imidazolyl)-2-((4-(2-chlorophenyl)piperazin-1-yl)heptyl)pyridazin-3(2H)-one  0   *Piperazines *Pyridazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2002 Aug 15;45(17):3603-11
6-(1-benzimidazolyl)-2-((4-(2-methoxyphenyl)piperazin-1-yl)butyl)pyridazin-3(2H)-one  0   *Piperazines *Pyridazines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 2002 Aug 15;45(17):3603-11
L 771688  0   *Pyrimidinones Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Eur J Pharmacol 2000 Dec 15;409(3):301-12
S 18327  0   *Imidazoles *Isoxazoles Receptors, Adrenergic, alpha-1/antagonists & inhibitors Receptors, Adrenergic, alpha-2. J Pharmacol Exp Ther 2000 Jan;292(1):38-53
RS 100329  0   *Piperazines Thymine Receptors, Adrenergic, alpha-1/antagonists & inhibitors. Br J Pharmacol 1999 May;127(1):252-8
Ro 70-0004  0   *Piperazines Thymine Receptors, Adrenergic, alpha-1. Br J Pharmacol 1999 May;127(1):252-8
cyclazosin  139953-73-4   *Quinazolines *Quinoxalines Receptors, Adrenergic, alpha-1/antagonists & inhibitors. J Med Chem 1993 Mar 19;36(6):690-8

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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