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Receptors, Adrenergic, alpha-1
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Definition
: A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
Other names
alpha-
1 Adrenergic Receptors; Receptors, alpha-
1 Adrenergic; Adrenergic alpha-
1 Receptors; alpha-
1D Receptors, Adrenergic; alpha-
1B Receptors, Adrenergic; alpha-
1A Receptors, Adrenergic; alpha-
1 Receptors, Adrenergic; alpha-
1 Adrenergic Receptor; alpha 1D Adrenergic Receptor; alpha 1C Adrenergic Receptor; alpha 1B Adrenergic Receptor; alpha 1A Adrenergic Receptor; alpha 1 Adrenergic Receptors; Receptors, alpha 1 Adrenergic; Receptors, Adrenergic alpha-
1D; Receptors, Adrenergic alpha-
1B; Receptors, Adrenergic alpha-
1A; Receptors, Adrenergic alpha-
1; Receptor, alpha-
1D Adrenergic; Receptor, alpha-
1C Adrenergic
Substance
CAS Registry & name
Categories
Source
Drugs
*
N-
((11-
(4-
methylpiperazin-
1-
yl)-
10,11-
dihydrodibenzo(b,f)thiepin-
2-
yl)methyl)isobutyramide
0
*Dibenzothiepins
Ligands
Receptors, Adrenergic, alpha-1.
J Med Chem 2010 Oct 14;53(19):7021-34
AdTx1 peptide, Dendroaspis angusticep
0
*Peptides
*Elapid Venoms
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Br J Pharmacol 2010 Jan 1;159(2):316-25
Adra1d protein, rat
0
*Receptors, Adrenergic, alpha-1.
Adra1d protein, mouse
0
*Receptors, Adrenergic, alpha-1.
ADRA1D protein, human
0
*Receptors, Adrenergic, alpha-1.
Adra1b protein, rat
0
*Receptors, Adrenergic, alpha-1.
Adra1b protein, mouse
0
*Receptors, Adrenergic, alpha-1.
ADRA1B protein, human
0
*Receptors, Adrenergic, alpha-1.
Adra1a protein, rat
0
*Receptors, Adrenergic, alpha-1.
Adra1a protein, mouse
0
*Receptors, Adrenergic, alpha-1.
ADRA1A protein, human
0
*Receptors, Adrenergic, alpha-1.
2-
(3-
(4-
(2-
isopropoxyphenyl)piperazin-
1-
yl)propyl)-
3a,4,7,7a-
tetrahydroisoindole-
1,3-
dione
0
*Phthalimides
*Piperazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Eur J Pharmacol 2009 Apr 1;607(1-3):213-9
2-
(4-
methylphenyll)-
2,3-
dihydro-
N-
(2-
hydroxy-
3-
(4-
(2-
(1-
methylethoxy)phenyl)-
1-
piperazinyl)propyl)-
1,3-
dioxo-
1H-
isoindole-
5-
carboxamide
0
*Phthalimides
*Piperazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
2-
(3-
fluorophenyl)-
2,3-
dihydro-
N-
(2-
hydroxy-
3-
(4-
(2-
(1-
methylethoxy)phenyl)-
1-
piperazinyl)propyl)-
1,3-
dioxo-
1H-
isoindole-
5-
carboxamide
0
*Phthalimides
*Piperazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Eur J Drug Metab Pharmacokinet 2006 Oct-Dec;31(4):271-6
N-
(2-
methyl-
(4-
indolyl-
1-
piperazinyl)ethyl)-
N-
(2-
pyridinyl)cyclohexane carboxamide
0
*Aminopyridines
*Piperazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors
Receptor, Serotonin, 5-HT1A/antagonists & inhibitors.
Auton Autacoid Pharmacol 2005 Oct;25(4):185-9
8-
(2-
(4-
(2,4,5-
trifluorophenyl)piperazin-
1-
yl)-
1-
methylethyl)-
8-
azaspiro(4.5)decane-
7,9-
dione
0
*Piperazines
*Spiro Compounds
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2005 Apr 21;48(8):3076-9
8-
(2-
(4-
(2,4,5-
trifluorophenyl)piperazin-
1-
yl)ethyl)-
8-
azaspiro(4.5)decane-
7,9-
dione
0
*Piperazines
*Spiro Compounds
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2005 Apr 21;48(8):3076-9
8-
(2-
(4-
(2,5-
dichlorophenyl)-
1-
piperazinyl)ethyl)-
8-
azaspiro(4,5)dec-
9,10-
en-
7-
one
0
*Imides
*Spiro Compounds
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2004 Apr 8;47(8):1900-18
8-
((4-
(2,5-
dichlorophenyl)-
1-
piperazinyl)ethyl)-
8-
azaspiro(4,5)decane-
7,9-
dione
0
*Imides
*Spiro Compounds
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2004 Apr 8;47(8):1900-18
4-
amino-
5-
(4-
fluorophenyl)-
6,7-
dimethoxy-
2-
(4-
(morpholinocarbonyl)-
-
perhydro-
1,4-
diazepin-
1-
yl)quinoline
0
*Azepines
*Quinolines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Drug Metab Dispos 2004 Feb;32(2):197-204
dabuzalgron
0
*Imidazoles
*Sulfonamides
Receptors, Adrenergic, alpha-1/agonists.
BJU Int 2004 Jan;93(1):162-70
2-
(2-
(n-
4-
o-
methoxyphenyl-
N-
1-
piperazinyl)ethyl)-
1-
tetralone
0
*Piperazines
*Tetralones
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Vascul Pharmacol 2003 Feb;40(2):97-108
4-
(2-
phenoxyethylaminomethyl)-
2,2-
diphenyl(1,3)dioxolane
0
*Dioxolanes
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2003 Apr 10;46(8):1504-11
4-
(2-
(2-
methoxyphenoxy)ethylaminomethyl)-
2,2-
diphenyl(1,3)dioxolane
0
*Dioxolanes
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2003 Apr 10;46(8):1504-11
2-
(4-
(4-
(2-
methoxyphenyl)piperazinyl)butyl)amino-
4-
cyclohexylaminoquinazoline
0
*Piperazines
*Quinazolines
Receptors, Adrenergic, alpha-1.
Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
4-
(3-
(4-
(2-
methoxyphenyl)piperazinyl)propyl)aminoquinazolin-
2-
carboxamide
0
*Piperazines
*Quinazolines
Receptors, Adrenergic, alpha-1.
Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
ethyl 4-
(3-
(4-
(2-
methoxyphenyl)piperazinyl)propyl)aminoquinazolin-
2-
carboxylate
0
*Piperazines
*Quinazolines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Eur J Pharmacol 2002 Jun 7;445(1-2):125-31
6-
(1-
indolyl)-
2-
((4-
(2-
methoxyphenyl)piperazin-
1-
yl)butyl)pyridazin-
3(2H)-
one
0
*Piperazines
*Pyridazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2002 Aug 15;45(17):3603-11
6-
(imidazolyl)-
2-
((4-
(2-
chlorophenyl)piperazin-
1-
yl)heptyl)pyridazin-
3(2H)-
one
0
*Piperazines
*Pyridazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2002 Aug 15;45(17):3603-11
6-
(1-
benzimidazolyl)-
2-
((4-
(2-
methoxyphenyl)piperazin-
1-
yl)butyl)pyridazin-
3(2H)-
one
0
*Piperazines
*Pyridazines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 2002 Aug 15;45(17):3603-11
L 771688
0
*Pyrimidinones
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Eur J Pharmacol 2000 Dec 15;409(3):301-12
S 18327
0
*Imidazoles
*Isoxazoles
Receptors, Adrenergic, alpha-1/antagonists & inhibitors
Receptors, Adrenergic, alpha-2.
J Pharmacol Exp Ther 2000 Jan;292(1):38-53
RS 100329
0
*Piperazines
Thymine
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
Br J Pharmacol 1999 May;127(1):252-8
Ro 70-
0004
0
*Piperazines
Thymine
Receptors, Adrenergic, alpha-1.
Br J Pharmacol 1999 May;127(1):252-8
cyclazosin
139953-73-4
*Quinazolines
*Quinoxalines
Receptors, Adrenergic, alpha-1/antagonists & inhibitors.
J Med Chem 1993 Mar 19;36(6):690-8