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alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid

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Definition: An IBOTENIC ACID homolog and glutamate agonist. The compound is the defining agonist for the AMPA subtype of glutamate receptors (RECEPTORS, AMPA). It has been used as a radionuclide imaging agent but is more commonly used as an experimental tool in cell biological studies.  DF: note short X ref   
Pharmacological Action Excitatory Amino Acid Agonists
See Also Receptors, AMPA 		Other names AMPA; alpha Amino 3 hydroxy 5 methyl 4 isoxazolepropioni; AMPA, (S)-Isomer, Monohydrobromide; AMPA, (S)-Isomer; AMPA, (R)-Isomer, Monohydrobromide; AMPA, (R)-Isomer; AMPA, (+-)-Isomer
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Org 26576  0   alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives. Psychopharmacology (Berl). 2009 Oct;206(2):215-22
2-amino-3-(3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl)propionic acid  0   *Tetrazoles alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives Receptors, AMPA/agonists. J Med Chem 2007 May 17;50(10):2408-14
2-amino-3-(3-hydroxy-4-isoxazoyl)propionic acid  0   alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives Ligands. FEBS Lett 2002 Nov 6;531(2):173-8
2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid  0   alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives. J Med Chem 1996 Aug 2;39(16):3188-94
6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid  0   *Phosphonic Acids *Quinolones Kainic Acid/antagonists & inhibitors alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/antagonists & inhibitors. J Med Chem 1996 Jan 5;39(1):197-206
alpha-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)methyl-5-methyl-3-oxo-4-isoxazoline-4-propionic acid  131417-67-9   alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives. Acta Neuropathol (Berl) 1991;81(3):255
alpha-amino-3-carboxymethoxy-5-methyl-4-isoxazolepropionic acid  131417-68-0   alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/*analogs & derivatives. Acta Neuropathol (Berl) 1991;81(3):255

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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