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Kainic Acid

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Definition: (2S-(2 alpha,3 beta,4 beta))-2-Carboxy-4-(1-methylethenyl)-3-pyrrolidineacetic acid. Ascaricide obtained from the red alga Digenea simplex. It is a potent excitatory amino acid agonist at some types of excitatory amino acid receptors and has been used to discriminate among receptor types. Like many excitatory amino acid agonists it can cause neurotoxicity and has been used experimentally for that purpose.  an antinematodal agent & excitatory amino acid agonist   
Pharmacological Action Antinematodal Agents; Excitatory Amino Acid Agonists
See Also Receptors, Kainic Acid 		Other names Digenic Acid; Acid, Kainic; Acid, Digenic; Kainate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
methoxyphenylkainic acid  0   Kainic Acid/*analogs & derivatives. Org Lett. 2011 Mar 4;13(5):1089-91
phenylkainic acid  0   Kainic Acid/*analogs & derivatives. Org Lett. 2011 Mar 4;13(5):1089-91
(2S,3R,4R)-3-carboxymethyl-4-(phenylthio)pyrrolidine-2-carboxylic acid  0   Kainic Acid/*analogs & derivatives. Eur J Pharmacol 2007 Dec 1;575(1-3):75-81
allokainic acid  0   Kainic Acid/*analogs & derivatives. Org Lett 2004 Jul 8;6(14):2481-4
acromelic acid B  0   Kainic Acid/*analogs & derivatives. J Org Chem 2001 Apr 20;66(8):2588-96
2-carboxy-4-(1-phenylethen-1-yl)pyrrolidine-3-acetic acid  0   Kainic Acid/*analogs & derivatives. J Med Chem 1996 Sep 13;39(19):3617-24
carboxy-2-nitrobenzyl kainate  0   Kainic Acid/*analogs & derivatives. Biochemistry 1996 Feb 13;35(6):2030-6
6,7-dichloro-2(1H)-oxoquinoline-3-phosphonic acid  0   *Phosphonic Acids *Quinolones Kainic Acid/antagonists & inhibitors alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid/antagonists & inhibitors. J Med Chem 1996 Jan 5;39(1):197-206
1'-hydroxykainic acid  125292-93-5   Kainic Acid/*analogs & derivatives. Nat Toxins 1994;2(5):286-92
4-(1-(4-azidobenzamidomethyl)ethenyl)-2-carboxypyrrolidin-3-ylacetic acid  0   *Azides Kainic Acid/*analogs & derivatives. Acta Chem Scand 1994 Jan;48(1):76-9
4-(2-hydroxyphenyl)-2-carboxy-3-pyrrolidineacetic acid  132785-32-1   Kainic Acid/*analogs & derivatives. Neurosci Lett 1992 May 11;139(1):114-7
4-(2-methoxyphenyl)-2-carboxy-3-pyrrolidineacetic acid  132785-33-2   Kainic Acid/*analogs & derivatives. Br J Pharmacol 1992 Dec;104(4):873-78
kainylaminooxyacetylglycine  119320-06-8   Glycine/*analogs & derivatives Kainic Acid/*analogs & derivatives. Brain Res 1989;476(1):57
acromelic acid A  86630-09-3   Kainic Acid/*analogs & derivatives. Brain Res 1986;399(2):395
alpha-ketokainic acid  75232-58-5   Kainic Acid/*analogs & derivatives Neurotoxins. J Comp Neurol 1982;211(2):105
kainic acid diethyl ester  66163-47-1   Kainic Acid/*analogs & derivatives. Neuropharmacology 1981;20(11):1013
dihydrokainic acid  52497-36-6 (2S-(2 alpha,3 beta,4 beta))-2-carboxy-4-(1- methylethyl)-3-pyrrolidineacetic acid  Kainic Acid/*analogs & derivatives. Eur J Pharmacol 56(3):287;1979
domoic acid  14277-97-5 3-pyrrolidineacetic acid, 2-carboxy-4-(5-carboxy-1-methyl-1,3-hexadienyl)-, (2S-(2 alpha,3 beta,4 beta(1E,3E,5R*)))  Kainic Acid/*analogs & derivatives Marine Toxins Neurotoxins.
Pharma Action Neuromuscular Depolarizing Agents 		Neuropharmacol 15(2):145;1976

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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