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Guanine Nucleotide Exchange Factors
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Definition
: Protein factors that promote the exchange of GTP for GDP bound to GTP-BINDING PROTEINS.
Examples
Eukaryotic Initiation Factor-2B
;
Guanine Nucleotide-Releasing Factor 2
;
Proto-Oncogene Proteins c-vav
;
ral Guanine Nucleotide Exchange Factor
;
ras Guanine Nucleotide Exchange Factors
Other names
Reversing Factors, GDP-
GTP; Guanine Nucleotide Releasing Factor; GDP GTP Reversing Factors; GDP GTP Exchange Protein; Factors, GDP-
GTP Reversing; Factors, GDP Exchange; Exchange Factors, GDP; Guanine-
Nucleotide-
Releasing Factor; Guanine Nucleotide Exchange Factor; GDP-
GTP Exchange Protein; GDP Dissociation Stimulators; GDP Dissociation Factor; Guanine Nucleotide Releasing Factors; GDP-
GTP Reversing Factors; GDP Exchange Factors
Substance
CAS Registry & name
Categories
Source
Drugs
*
FGD5 protein, human
0
*Guanine Nucleotide Exchange Factors.
Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):988-96.
connecdenn 3 protein, human
0
*Microfilament Proteins
*Guanine Nucleotide Exchange Factors.
Mol Biol Cell. 2012 Jan;23(1):163-75.
Swap70 protein, zebrafish
0
*Nuclear Proteins
*Guanine Nucleotide Exchange Factors
*Zebrafish Proteins.
Mol Cell Neurosci. 2011 Nov;48(3):225-35
Ric-
8A protein, human
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2011 Sep 2;286(35):31055-61
DOCK10 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Hum Immunol. 2011 Jul;72(7):531-7
Dbl protein, rat
0
*Guanine Nucleotide Exchange Factors.
Am J Physiol Gastrointest Liver Physiol 2011 Jun;300(6):G988-97
Ric8b protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Dennd4C protein, mouse
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2011 May 13;286(19):16541-5
Dennd4C protein, human
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2011 May 13;286(19):16541-5
LARG protein, Xenopus
0
*Guanine Nucleotide Exchange Factors
*Xenopus Proteins.
Biofizika. 2010 Nov-Dec;55(6): 1002-7
Arfgef2 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Int J Dev Biol. 2010;54(8-9):1259-66
Vps9a protein, Arabidopsis
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2010 Nov 19;285(47):36689-97
ARHGEF16 protein, human
0
*Guanine Nucleotide Exchange Factors.
Br J Cancer 2011 Jan 18;104(2):324-31
RopGEF1 protein, Arabidopsis
0
*Guanine Nucleotide Exchange Factors
*Arabidopsis Proteins.
J Biol Chem 2010 Oct 15;285(42):32151-9
Rabex-
5 protein, Drosophila
EC 6.3.2.19
*Drosophila Proteins
*Ubiquitin-Protein Ligases
Guanine Nucleotide Exchange Factors.
Curr Biol 2010 aug 10;20(15):1378-82
Ric1 protein, S pombe
0
*Guanine Nucleotide Exchange Factors
*Schizosaccharomyces pombe Proteins.
Mol Genet Genomics 2010 Sep;284(3):161-71
p190RhoGEF protein, human
0
*Guanine Nucleotide Exchange Factors.
Amyotroph Lateral Scler 2010;11(1-2):97-103
IQSEC2 protein, human
0
*Guanine Nucleotide Exchange Factors.
Nat Genet 2010 Jun;42(6):486-8
VPS39 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2010 May 28;285(22):16814-21
Lfc protein, rat
0
*Guanine Nucleotide Exchange Factors.
J Neurosci 2010 May 12;30(19):6793-800
FGD3 protein, human
0
*Guanine Nucleotide Exchange Factors.
Genes Cells 2008 Apr;13(4):329-42
RalGPS2 protein, rat
0
*Guanine Nucleotide Exchange Factors.
Neurosci Res. 2010 Mar;66(3):290-8
kalirin protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Mol Cell Neurosci 2010 Jan;43(1):81-9
CGEF-
1 protein, C elegans
0
*Guanine Nucleotide Exchange Factors
*Caenorhabditis elegans Proteins.
Mol Biol Cell 2010 Jan;21(2):266-77
Asef2 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
EMBO Rep 2009 Dec;10(12):1355-62
Asef protein, mouse
0
*Guanine Nucleotide Exchange Factors.
EMBO Rep 2009 Dec;10(12):1355-62
RanBP10 protein, mouse
0
*Microtubule-Associated Proteins
*Guanine Nucleotide Exchange Factors.
Blood 2009 Dec 24;114(27):5532-40
DENND1B protein, human
0
*Guanine Nucleotide Exchange Factors
*Death Domain Receptor Signaling Adaptor Proteins.
N Engl J Med. 2010 Jan 7;362(1):36-44
Varp protein, rat
0
*Guanine Nucleotide Exchange Factors
Ankyrin Repeat.
Dock8 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Nat Immunol 2009 Dec;10(12):1283-91
ARHGEF5 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2009 Oct 16;284(42):28599-606
Epac protein, Drosophila
0
*Guanine Nucleotide Exchange Factors
*Drosophila Proteins.
Mol Cell Endocrinol. 2009 Jun 16;305(1-2); 30-7
zizimin1 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
J Neurosci Res 2009 Jun;87(8):1794-805
BRAG1 protein, mouse
0
*Nerve Tissue Proteins
*Guanine Nucleotide Exchange Factors.
Brain Res 2009 Jan 28;1251:7-15
SidM protein, Legionella pneumophila
0
*Bacterial Proteins
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2009 Feb 20;284(8):4846-56
Dock7 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Proc Natl Acad Sci U S A 2009 Feb 24;106(8):2706-11
ephexin protein, Drosophila
0
*Guanine Nucleotide Exchange Factors
*Drosophila Proteins.
Neuron 2009 Feb 26;61(4):556-69
Sec12 protein, Drosophila
0
*Guanine Nucleotide Exchange Factors
*Drosophila Proteins.
Mol Biol Cell 2008 Oct;19(10):4352-65
P-
Rex1 protein, rat
0
*Guanine Nucleotide Exchange Factors.
J Cell Sci 2008 Sep 1;121(Pt 17):2892-903
syx protein, zebrafish
0
*Guanine Nucleotide Exchange Factors
*Zebrafish Proteins.
Circ Res 2008 Sep 26;103(7):710-6
Epac-
2 protein, rat
0
*Guanine Nucleotide Exchange Factors.
J Physiol 2001 Oct 15;536(Pt 2):375-85
Dock5 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Exp Eye Res 2008 May;86(5):828-34
Als2 protein, rat
0
*Guanine Nucleotide Exchange Factors.
Neurobiol Dis 2005 Mar;18(2):243-57
Dock10 protein, human
0
*Guanine Nucleotide Exchange Factors.
Mol Immunol 2008 Jul;45(12):3411-8
GEFT protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Proc Natl Acad Sci U S A 2008 Jun 17;105(24):8298-303
RANBP10 protein, human
0
*Microtubule-Associated Proteins
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2008 May 16;283(20):14109-19
Varp protein, human
0
*Guanine Nucleotide Exchange Factors
Ankyrin Repeat.
Biochem Biophys Res Commun 2008 Jul 18;372(1):162-7
Gapex-
5 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
Nature 2008 May 8;453(7192):241-5
Get3 protein, S cerevisiae
EC 3.6.3.16
*Adenosine Triphosphatases
*Guanine Nucleotide Exchange Factors
*Saccharomyces cerevisiae Proteins.
Biometals 2003 Sep;16(3):369-78
Dock180 protein, mouse
0
*Guanine Nucleotide Exchange Factors.
J Cell Biol 2008 Mar 10;180(5):1005-19
PLEKHG2 protein, human
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2008 Jan 25;283(4):1946-53
PLEKHG6 protein, human
0
*Guanine Nucleotide Exchange Factors.
Mol Biol Cell 2007 Dec;18(12):4780-93
Epac-
1 protein, rat
0
*Guanine Nucleotide Exchange Factors.
Exp Cell Res 2008 Jan 15;314(2):255-63
Akap13 protein, mouse
0
*Guanine Nucleotide Exchange Factors
*A Kinase Anchor Proteins.
J Biol Chem 2007 Nov 30;282(48):35308-17
Ric-
8 protein, Xenopus
0
*Guanine Nucleotide Exchange Factors
*Xenopus Proteins.
J Cell Physiol 2008 Mar;214(3):673-80
SPATA13 protein, human
0
*Guanine Nucleotide Exchange Factors.
Oncogene 2007 Dec 6;26(55):7620-267
RopGEF12 protein, Arabidopsis
0
*Guanine Nucleotide Exchange Factors
*Arabidopsis Proteins.
Proc Natl Acad Sci U S A 2007 Nov 20;104(47):18830-5
KIAA1110 protein, human
0
*Guanine Nucleotide Exchange Factors.
Biochem Biophys Res Commun 2007 Dec 28;364(4):737-42
ephexin protein, human
0
*Guanine Nucleotide Exchange Factors.
J Biol Chem 2007 Oct 19;282(42):31103-12
PDZ-
RhoGEF, rat
0
*Guanine Nucleotide Exchange Factors.
J Hypertens 2007 Aug;25(8):1687-97
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