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Artemisinins

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Definition: A group of SESQUITERPENES and their analogs that contain a peroxide group (PEROXIDES) within an oxepin ring (OXEPINS).     
Pharmacological Action Antimalarials
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Artenimol-R  0   *Artemisinins Antineoplastic Agents Uterine Cervical Neoplasms/drug therapy. Anticancer Res. 2011 Dec;31(12):4417-22
SM1044  0   *Artemisinins Antineoplastic Agents. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):607-11
arteanuine B  0   *Artemisinins Trypanocidal Agents. Phytomedicine. 2011 Aug 15;18(11):959-69
transtaganolide C  0   *Artemisinins. Angew Chem Int Ed Engl. 2011 Apr 11;50(16):3688-91
3-alpha-hydroxyartemisinic acid  0   *Artemisinins. Zhong Yao Cai. 2010 May;33(5):662-5
beta-aminoarteether maleate  0   *Artemisinins. Int Immunopharmacol 2009 Dec;9(13-14):1509-17
artemisinin-naphthoquine combination  0   *Naphthoquinones *Artemisinins. Malar J. 2009;8() (dup#82):196
transtaganolide D  0   *Artemisinins. Org Lett 2009 Feb 5;11(3):601-4
10beta-(trifluoropropyloxy)dihydroartemisinin  0   *Artemisinins. J Pharm Pharmacol. 2008 Feb;60(2):163-9
ethyl 2-(4-(12-beta-artemisininoxy))phenoxylpropionate  0   *Artemisinins. J Immunol 2007 Nov 1;179(9):5958-65
SM905  0   *Artemisinins. Eur J Pharmacol 2007 Jun 14;564(1-3):211-8
dihydroartemisinic acid  0   *Artemisinins. J Agric Food Chem 2007 Mar 7;55(5):1686-94
7-hydroxyartemisinin  0   *Artemisinins. Appl Microbiol Biotechnol 2004 Jun;64(6):782-6
5-hydroxyartemisinin  0   *Artemisinins. J Ind Microbiol Biotechnol 2006 May;33(5):349-52
3-(12-beta-artemisininoxy) phenoxyl succinic acid  0   *Succinic Acids *Artemisinins. Acta Pharmacol Sin. 2005 Nov;26(11):1352-8
dihydroartemisinin 2-(biphenyl-2-yloxy)ethyl ether  0   *Artemisinins. J Med Chem 2006 Nov 30;49(24):7227-33
dihydroartemisinin 4-biphenylmethyl ether  0   *Artemisinins. J Med Chem 2006 Nov 30;49(24):7227-33
amodiaquine, artesunate drug combination  0   *Amodiaquine *Artemisinins Drug Combinations.
Pharma Action Antimalarials
artemether-lumefantrine combination  0   *Ethanolamines *Fluorenes *Artemisinins Drug Combinations.
Pharma Action Antimalarials 		COARTEM
artemisone  0   *Artemisinins. Am J Trop Med Hyg 2006 Oct;75(4):637-9
99-357 compound  0   *Artemisinins. J Pharm Biomed Anal 2004 Oct 29;36(2):371-6
15-hydroxy-10-deoxoartemisinin  0   *Artemisinins. Biotechnol Lett 2004 Apr;26(7):607-10
deoxoartemisitene  0   *Artemisinins. Bioorg Med Chem Lett 2004 Apr 19;14(8):2001-3
O-aminodihydroartemisinin  0   *Amines *Artemisinins. J Org Chem. 2004 Apr 30;69(9):3243-4
10-(2-(3-trifluoromethylphenylpiperazyl)ethyl)deoxoartemisinin  0   *Piperazines *Artemisinins. J Med Chem 2002 Feb 28;45(5):1052-63
deoxyarteannuin B  0   *Artemisinins Artemisia. Phytochemistry 2001 Dec;58(8):1159-66
dihydroartemisinin beta-glucuronide  0   *Glucuronides *Artemisinins. J Med Chem 2001 Apr 26;44(9):1467-70
10-(4-trifluoromethylphenoxy)dihydroartemisinin  0   *Phenyl Ethers *Artemisinins. J Med Chem 2001 Jan 4;44(1):58-68
10-phenoxydihydroartemisinin  0   *Phenyl Ethers *Artemisinins. J Med Chem 2001 Jan 4;44(1):58-68
carboxypropyldeoxoartemisinine  0   *Artemisinins Artemisia. Biochem Biophys Res Commun 2000 Aug 2;274(2):359-69
artemisinin trioxane alcohol  0 octahydro-3,10-epoxy-9-(2-hydroxyethyl)-10-methoxy-3-methyl-1,2-benzodioxepine  *Heterocyclic Compounds, 3-Ring *Artemisinins Artemisia. FEBS Lett 2000 Jun 2;474(2-3):238-41
1-diethylamino-2-(10-dihydroartemisinoxy)ethane  0   *Artemisinins. J Med Chem 2000 Apr 20;43(8):1635-40
1-morpholino-3-(10-dihydroartemisinoxy)propane  0   *Artemisinins. J Med Chem 2000 Apr 20;43(8):1635-40
1-dimethylamino-2-(10-dihydroartemisinoxy)ethane  0   *Artemisinins. J Med Chem 2000 Apr 20;43(8):1635-40
artesunic acid  88495-63-0   *Succinates *Artemisinins. J Pharm Pharmacol 1998 Feb;50(2):173-82
artemisinin G  0   *Artemisinins Artemisia. J Pharm Pharmacol 1997 Dec;49(12):1254-8
artemisitene  101020-89-7   *Artemisinins. J Med Chem 1997 Feb 28;40(5):633-8
methyl artemisinate  0   *Acrylates *Naphthalenes *Artemisinins. Planta Med 1996 Aug;62(4):359-60
13-carbaartemisinin  0   *Artemisinins Artemisia. J Med Chem 1996 Apr 26;39(9):1885-97
N-(2'-acetaldehydo)-11-azaartemisinin  0   *Artemisinins. J Med Chem 1995 Dec 22;38(26):5045-50
artenibenzoate  0   *Artemisinins Artemisia. Yao Hsueh Hsueh Pao 1995;30(6):422-7
12-allyldeoxoartemisinin  0   *Artemisinins Artemisia. J Med Chem 1995 Feb 17;38(4):613-6
arteflene  123407-36-3   *Styrenes *Bicyclo Compounds, Heterocyclic *Artemisinins. Antimicrob Agents Chemother 1994 Aug;38(8):1854-8
anhydrodihydroartemisinin  0   *Artemisinins. Pharm Res 1994 Jul;11(7):990-4
artemisin  481-05-0   *Lactones *Artemisinins Artemisia. J Chromatogr 1992 Feb 28;593(1-2):209-15
artemisinin B  145941-07-7   *Artemisinins Artemisia. Yao Hsueh Hsueh Pao 1991;26(7):557-60
deoxoartemisinin  126189-95-5 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-3,6,9-trimethyl-, (3R-(3alpha,5abeta,6beta,8abeta,9alpha,12beta,12aR*))  *Artemisinins. J Med Chem 1990;33(5):1516
artelinic acid  109637-83-4   *Artemisinins. J Chromatogr 1989;495:167
yingzhaosu C  121067-52-5 1,2-Dioxane-3-methanol, alpha,alpha,6-trimethyl-6-(4-methylphenyl)-, (3R-trans)  *Peroxides *Sesquiterpenes Malaria Annonaceae Artemisinins. Sci China (B) 1989;32(7):800
3-hydroxydeoxyartemisinin  82003-85-8   *Artemisinins Artemisia. J Nat Prod 1989;52(2):337
deoxyartemisinin  72826-63-2 10aH-9,10b-Epoxypyrano(4,3,2-jk)(2)benzoxepin-2(3H)-one, octahydro-3,6,9-trimethyl-, (3R-(3alpha,3abeta,6beta,6abeta,9beta,10aalpha,10bbeta))  *Artemisinins Artemisia. Chung Kuo Yao Li Hsueh Pao 1987;8(4):355
arteether  109716-83-8   *Artemisinins.
Pharma Action Amebicides ; Antimalarials ; Schistosomicides 		J Med Chem 1988;31(3):645
artemisic acid  80286-58-4   *Artemisinins Artemisia. Chung Yao Tung Pao 1985;10(9):35
ascaridole  512-85-6   *Peroxides *Monoterpenes Chenopodium Artemisinins. Arch Biochem Biophys 1984;235(1):254
artesunate  83507-69-1   *Artemisinins Artemisia.
Pharma Action Amebicides ; Antimalarials 		J Tradit Chin Med 1983;3(3):171
alpha-propoxycarbonyldihydroartemisine  71939-53-2   *Artemisinins. Trans R Soc Trop Med Hyg 1983;77(4):522
dihydroquinghaosu  71939-50-9   *Artemisinins Artemisia.
Pharma Action Antimalarials 		Biochem Pharmacol 1983;32(17):2463
artemether  0 (3R-(3.alpha.,5a.beta.,6.beta.,8a.beta.,9.alpha.,10.alpha.,12.beta.,12aR*))-Decahydro-10-methoxy-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4.3-j)-1,2-benzodioxepin  *Artemisinins Artemisia.
Pharma Action Antifungal Agents ; Antimalarials ; Antiprotozoal Agents ; Coccidiostats ; Schistosomicides 		Chung-Kuo Yao Li Hsueh Pao 1981;2(2):138
artemisinine  63968-64-9   *Artemisinins Artemisia.
Pharma Action Anti-Infective Agents 		Chung Yao Tung Pao 1981;6(4):25; Yao Hsueh Hsueh Pao 1981;16(6):460
arteannuin B  50906-56-4   *Artemisinins Artemisia. Helv Chim Acta 57(3):533;1974
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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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