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Cyclin-Dependent Kinase 9

More information in Books or onNLM PubMed
Definition: A multifunctional CDC2 kinase-related kinase that plays roles in transcriptional elongation, CELL DIFFERENTIATION, and APOPTOSIS. It is found associated with CYCLIN T and is a component of POSITIVE TRANSCRIPTIONAL ELONGATION FACTOR B.  see SCR for organism-specific terms    Other names PITALRE, Cdc2-related Kinase; Kinase PITALRE, Cdc2-related; Cyclin Dependent Kinase 9; Cdc2 related Kinase PITALRE; PITALRE Kinase; Cdc2-related Kinase PITALRE; CDK9 Kinase; Cdk9 Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CAN 508  0   *Azo Compounds *Pyrazoles Cyclin-Dependent Kinase 9/antagonists & inhibitors. Eur J Med Chem. 2011 Sep;46(9):4289-94.
4-amino-6-bromo-1-(3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-1H-pyrrolo(2,3-d)pyrimidine-5-carboxamide  0   *Pyrimidine Nucleosides Cyclin-Dependent Kinase 9/antagonists & inhibitors. J Biol Chem 2011 Jun 3;286(22):19662-71
(5-(4-amino-6-bromo-5-carbamoyl-1H-pyrrolo(2,3-d)pyrimidin-1-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl isobutyrate  0   *Pyrimidine Nucleosides Cyclin-Dependent Kinase 9/antagonists & inhibitors. J Biol Chem 2011 Jun 3;286(22):19662-71
3-(7-(benzylamino)-3-isopropylpyrazolo(1,5-a)pyrimidin-5-ylamino)-1,2,4-butanetriol  0   *Pyrazoles *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 9/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors. J Med Chem 2010 Dec 23;53(24):8508-22
Cdk9 protein, zebrafish  EC 2.7.1.37   *Zebrafish Proteins *Cyclin-Dependent Kinase 9. Development 2006 Dec;133(24):4913-23
Cdk9 protein, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinase 9.
CDK9 protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinase 9.
cdk9 protein kinase, C elegans  EC 2.7.1.37   *Caenorhabditis elegans Proteins *Cyclin-Dependent Kinase 9.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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