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Cyclin-Dependent Kinase 2

More information in Books or onNLM PubMed
Definition: A key regulator of CELL CYCLE progression. It partners with CYCLIN E to regulate entry into S PHASE and also interacts with CYCLIN A to phosphorylate RETINOBLASTOMA PROTEIN. Its activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P27 and CYCLIN-DEPENDENT KINASE INHIBITOR P21.      Other names Cyclin Dependent Kinase 2; Cdc2 Related Protein Kinase; p33cdk2 Kinase; Cdc2-Related Protein Kinase; CDK2 Protein; Cdk2 Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-(((1,2-dicyano-2-(((4-methoxyphenyl)methylene)amino)vinyl)amino)carbonyl)-4-methylbenzenesulfonamide  0   *Sulfonamides Cyclin A/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors. Bioorg Med Chem 2010 Nov 1;18(21):7639-50
3-(7-(benzylamino)-3-isopropylpyrazolo(1,5-a)pyrimidin-5-ylamino)-1,2,4-butanetriol  0   *Pyrazoles *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 9/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors. J Med Chem 2010 Dec 23;53(24):8508-22
N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine  0   *Benzimidazoles *Indazoles CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors Cyclin-Dependent Kinase 4/antagonists & inhibitors. Cancer Chemother Pharamcol 2008 Nov;62(6):1091-101
CDK2 protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinase 2.
Cdk2 protein, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinase 2.
Cdk2 protein, rat  EC 2.7.1.37   *Cyclin-Dependent Kinase 2.
Cdk2 protein, Xenopus  EC 2.7.1.37   *Xenopus Proteins *Cyclin-Dependent Kinase 2.
cdc2c protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Cyclin-Dependent Kinase 2.
NU6102  0   *Purines Cyclin-Dependent Kinase 2/antagonists & inhibitors. Nat Struct Biol 2002 Oct;9(10):745-9
cdc2rk protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Cyclin-Dependent Kinase 2. J Biochem (Tokyo) 1994 Jan;115(1):150-5

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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