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Cyclin-Dependent Kinase 4

More information in Books or onNLM PubMed
Definition: Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.      Other names p34PSK J3 Kinase; Protein Kinase, Cdk4; PSK J3 Kinase; Cyclin-Dependent Kinase, Cdk4; Cyclin Dependent Kinase 4; Cyclin D Dependent Kinase CDK4; Cdk4 Cyclin Dependent Kinase; p34PSK-J3 Kinase; PSK-J3 Kinase; Cyclin D-Dependent Kinase CDK4; Cell Division Protein Kinase 4; Cdk4 Protein; Cdk4 Cyclin-Dependent Kinase; Cdk4 Protein Kinase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine  0   *Benzimidazoles *Indazoles CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors Cyclin-Dependent Kinase 4/antagonists & inhibitors. Cancer Chemother Pharamcol 2008 Nov;62(6):1091-101
2-bromo-12,13-dihydro-5-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione  0   *Carbazoles Cyclin-Dependent Kinase 4/antagonists & inhibitors. Cell Cycle 2007 Jun;6(11):1293-7
CA 224  0   *Biphenyl Compounds *Indoles Cyclin-Dependent Kinase 4/antagonists & inhibitors. Bioorg Med Chem Lett 2006 Aug 15;16(16):4272-8
Cdk4 protein, rat  EC 2.7.1.37   *Cyclin-Dependent Kinase 4.
Cdk4 protein, mouse  EC 2.7.1.37   *Cyclin-Dependent Kinase 4.
CDK4 protein, human  EC 2.7.1.37   *Cyclin-Dependent Kinase 4.
Cdk4 protein, Xenopus  EC 2.7.1.37   *Xenopus Proteins *Cyclin-Dependent Kinase 4.
Cdk4 protein, Drosophila  EC 2.7.1.37   *Drosophila Proteins *Cyclin-Dependent Kinase 4.

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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