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CDC2 Protein Kinase

More information in Books or onNLM PubMed
Definition: Phosphoprotein with protein kinase activity that functions in the G2/M phase transition of the CELL CYCLE. It is the catalytic subunit of the MATURATION-PROMOTING FACTOR and complexes with both CYCLIN A and CYCLIN B in mammalian cells. The maximal activity of cyclin-dependent kinase 1 is achieved when it is fully dephosphorylated.      Other names p34cdc2 Protein; Protein p34cdc2; Histone Kinase p34(cdc2); Cyclin-Dependent Kinase 1; Cdk1 Protein Kinase; p34cdc2, Protein; Protein Kinase, Cdk1; Protein Kinase, CDC2; Cyclin Dependent Kinase 1; cdk1 Kinase; cdc2+ Protein
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
3-(7-(benzylamino)-3-isopropylpyrazolo(1,5-a)pyrimidin-5-ylamino)-1,2,4-butanetriol  0   *Pyrazoles *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 9/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors. J Med Chem 2010 Dec 23;53(24):8508-22
N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine  0   *Benzimidazoles *Indazoles CDC2 Protein Kinase/antagonists & inhibitors Cyclin-Dependent Kinase 2/antagonists & inhibitors Cyclin-Dependent Kinase 4/antagonists & inhibitors. Cancer Chemother Pharamcol 2008 Nov;62(6):1091-101
4-amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo(3,4-d)pyrimidine  0   *Pyrazoles *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors. J Cell Sci 2008 Mar 15;121(Pt 6):843-53
RO 3306  0   *Quinolines *Thiazoles CDC2 Protein Kinase/antagonists & inhibitors. Proc Natl Acad Sci U S A 2006 Jul 11;103(28):10660-5
3-(4-(4-(3-chlorophenylamino)-(1,3,5)triazin-2-yl)pyridin-2-ylamino)propan-1-ol  0   *Aminopyridines *Triazines CDC2 Protein Kinase/antagonists & inhibitors. J Med Chem 2005 Jul 14;48(14):4535-46
BMI 1026  0   *Phenols *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors. Cancer Res 2003 Nov 1;63(21):7384-91
4-cyclohexylmethoxy-5-nitrosopyrimidine-2,6-diamine  0   *Nitroso Compounds *Pyrimidines CDC2 Protein Kinase/antagonists & inhibitors. Bioorg Med Chem Lett 2003 Jan 20;13(2):217-22
6-((3-chloro)anilino)-2-(isopropyl-2-hydroxyethylamino)-9-isopropylpurine  0   *Purines CDC2 Protein Kinase/antagonists & inhibitors. Cancer Cell 2002 Jul;2(1):43-54
cdc2 protein, S pombe  EC 2.7.1.37   *CDC2 Protein Kinase *Schizosaccharomyces pombe Proteins.
CDC2A protein, Arabidopsis  0   *CDC2 Protein Kinase *Arabidopsis Proteins. Eur J Biochem 2000 Dec;267(23):6775-83
2-(2-chlorophenoxy)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-1-benzopyran-4-one  0   *Chromones *Piperidines CDC2 Protein Kinase/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4126-34
2-((2-chlorophenyl)thio)-5,7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-4H-1-benzopyran-4-one  0   *Chromones *Piperidines CDC2 Protein Kinase/antagonists & inhibitors. J Med Chem 2000 Nov 2;43(22):4126-34
alsterpaullone  0   *Benzazepines *Indoles CDC2 Protein Kinase Cyclin B. J Med Chem 1999 Jul 29;42(15):2909-19
bohemine  0   *Purines CDC2 Protein Kinase/antagonists & inhibitors. Plant J 1998 Dec;16(6):697-707
CRK3 kinase, protozoa  EC 2.7.10.-   *Protozoan Proteins *CDC2 Protein Kinase. Mol Biochem Parasitol 1998 Oct 30;96(1-2):139-50
CDKL1 protein, human  EC 2.7.11.22   *Nerve Tissue Proteins *Cyclin-Dependent Kinases CDC2 Protein Kinase. J Neurochem 1995 Dec;65(6):2577-84
crk2 protein, Trypanosoma brucei  EC 2.7.1.37   *Protozoan Proteins *CDC2 Protein Kinase. Gene 1995 Aug 30;162(1):147-52
crk1 protein,Trypanosoma brucei  EC 2.7.1.37   *Protozoan Proteins *CDC2 Protein Kinase. Gene 1995 Aug 30;162(1):147-52
Pfcrk-1 protein, Plasmodium falciparum  0   *Protozoan Proteins *CDC2 Protein Kinase. Mol Biochem Parasitol 1995 Mar;70(1-2):167-74
CDC2 peptide (9-19)  142570-54-5   *Peptide Fragments *CDC2 Protein Kinase. Pept Res 1992 Jul-Aug;5(4):233-40
cdc2(6-20)NH2  136688-17-0   *Peptide Fragments *CDC2 Protein Kinase. J Biol Chem 1992 May 5;267(13):9248-56
CDK13 protein, human  EC 2.7.1.-   *CDC2 Protein Kinase Cell Cycle. Proc Natl Acad Sci USA 1992;89(2):579
Cys-cdc2 (8-20)  0   *Peptide Fragments *CDC2 Protein Kinase. J Biol Chem 1991;266(27):17919
PSTAIR peptide  126675-53-4   *Peptide Fragments *CDC2 Protein Kinase. Science 1990;247(4940):327

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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