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Receptor, Adenosine A2B
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Definition
: A subclass of adenosine A2 receptors found in the CECUM, the COLON, the BLADDER, and a variety of other tissues. It is generally considered to be a low affinity receptor for ADENOSINE that couples to the GS, STIMULATORY G-PROTEIN.
Other names
Receptors, Adenosine A2B; A2B Receptors, Adenosine; A2B Receptor, Adenosine; Adenosine A2B Receptors; Adenosine A(2B) Receptor; Adenosine A2B Receptor
Substance
CAS Registry & name
Categories
Source
Drugs
*
adora2b protein, zebrafish
0
*Zebrafish Proteins
*Receptor, Adenosine A2B.
Gene Expr Patterns 2009 Mar;9(3):144-51
4'-
(2-
furyl)-
N-
pyridin-
3-
yl-
4,5'-
bipyrimidin-
2'-
amine
0
*Furans
*Pyrimidines
Receptor, Adenosine A2B/antagonists & inhibitors.
J Med Chem 2007 May 31;50(11):2732-6
2-
(3''-
(6''-
bromoindolyl)ethyloxy)adenosine
0
Adenosine/*analogs & derivatives
Receptor, Adenosine A2B/agonists.
J Med Chem 2007 Apr 19;50(8):1810-27
BAY 60-
6583
0
*Aminopyridines
Receptor, Adenosine A2B/agonists.
Circulation 2007 Mar 27;115(12):1581-90
1-
propyl-
8-
(4-
sulfophenyl)xanthine
0
*Xanthines
Receptor, Adenosine A2B/antagonists & inhibitors.
J Med Chem 2004 Feb 12;47(4):1031-43
N(epsilon)-
thioacetyllysine
0
Lysine/*analogs & derivatives
Receptor, Adenosine A2B.
Bioorg Med Chem Lett 2006 Jul 15;16(14):3651-6
8-
(4-
(4-
benzylpiperazide-
1-
sulfonyl)phenyl)-
1-
propylxanthine
0
*Sulfonamides
*Xanthines
Receptor, Adenosine A2B/antagonists & inhibitors.
J Med Chem 2006 Jul 13;49(14):4384-91
8-
(1-
(3-
(trifluoromethyl)benzyl)-
1H-
pyrazol-
4-
yl)-
1,3-
dimethylxanthine
0
*Pyrazoles
Theophylline/*analogs & derivatives
Receptor, Adenosine A2B/antagonists & inhibitors.
J Med Chem 2006 Jun 15;49(12):3682-92
N-
(4-
acetylphenyl)-
2-
(4-
(2,3,6,7-
tetrahydro-
2,6-
dioxo-
1,3-
dipropyl-
1H-
purin-
8-
yl)phenoxy)acetamide
0
*Purines
Receptor, Adenosine A2B/antagonists & inhibitors.
2-
amino-
4-
(4-
hydroxyphenyl)-
6-
(1H-
imidazol-
2-
ylmethylsulfanyl)pyridine-
3,5-
dicarbonitrile
0
*Aminopyridines
*Imidazoles
Receptor, Adenosine A2B/agonists.
J Med Chem 2004 Jul 15;47(15):3707-9
N-
(2-
(2-
phenyl-
6-
(4-
(3-
phenylpropyl)piperazine-
1-
carbonyl)-
7H-
pyrrolo(2,3-
d)pyrimidin-
4-
ylamino)ethyl)acetamide
0
*Pyrroles
*Pyrimidines
Ligands
Tritium
Receptor, Adenosine A2B/antagonists & inhibitors.
Biochem Pharmacol 2004 Jul 15;68(2):305-12